Results 91 to 100 of about 19,457 (207)
Interplay of channels, pumps and organelle location in calcium microdomain formation
New Journal of Physics, 2013 To analyze the influence of Ca ^2+ microdomains on the global cytosolic Ca ^2+ concentration, we consider the polarization and activation of T-cells after the formation of an immunological synapse as a model system.
Martin Peglow +3 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.The aim of this study was to improve the long‐term LL‐37 mouse model and compare the disease manifestations and pathophysiology of short‐term and long‐term LL‐37‐induced rosacea‐like models. The results show that the long‐term LL‐37 induced mouse model provides a practical animal model for further study of the pathological mechanism of severe rosacea ...
Yiling Wu +10 more
wiley +1 more source
SegET: Deep Neural Network with Rich Contextual Features for Cellular Structures Segmentation in Electron Tomography Image [PDF]
arXiv, 2018 Electron tomography (ET) allows high-resolution reconstructions of macromolecular complexes at nearnative state. Cellular structures segmentation in the reconstruction data from electron tomographic images is often required for analyzing and visualizing biological structures, making it a powerful tool for quantitative descriptions of whole cell ...
arxiv
Arthritis &Rheumatology, EarlyView.Objective In rheumatoid arthritis (RA) and spondyloarthritis (SpA), managing persistent pain remains challenging. Little is known regarding impaired pain pathways in these patients and the impact of biologic disease‐modifying antirheumatic drugs (bDMARDs).
Anne‐Priscille Trouvin +9 more
wiley +1 more source
The role of Protein Kinase Cη in T cell biology
Frontiers in Immunology, 2012 Protein kinase Cη (PKCη) is a member of the novel PKC subfamily, which also includes δ, ε, and θ isoforms. Compared to the other novel PKCs, the function of PKCη in the immune system is largely unknown.
Nicholas R.J. Gascoigne
doaj +1 more source
Modelling Immunological Memory [PDF]
In Silico Immunology, 83-108, 2006, 2010 Accurate immunological models offer the possibility of performing highthroughput experiments in silico that can predict, or at least suggest, in vivo phenomena. In this chapter, we compare various models of immunological memory. We first validate an experimental immunological simulator, developed by the authors, by simulating several theories of ...
arxiv
Harnessing Viral Proteases for Cellular and Molecular Engineering
Chemistry–Methods, EarlyView.Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui +2 more
wiley +1 more source
Formation of dilute adhesion domains driven by weak elasticity-mediated interactions [PDF]
arXiv, 2016 Cell-cell adhesion is established by specific binding of receptor and ligand proteins. The adhesion bonds attract each other and often aggregate into large clusters that are central to many biological processes. One possible origin of attractive interactions between adhesion bonds is the elastic response of the membranes to their deformation by the ...
arxiv
Clinical Pharmacology &Therapeutics, EarlyView.Adverse drug reactions (ADRs) are a common cause of morbidity and mortality in hospitalized patients. Identification of ADRs in clinical practice, surveillance and research is essential to prevent further harm. The aim of this study was to assess the likelihood of drugs contributing to clinically important inpatient adverse events, in order to provide ...
Anna Maria Wermund +5 more
wiley +1 more source
Impact of Mycobacterium tuberculosis Glycolipids on the CD4+ T Cell-Macrophage Immunological Synapse. [PDF]
J Immunol, 2023 Mwebaza I +7 more
europepmc +1 more source