Results 91 to 100 of about 491,747 (317)

Intercellular transfer of oncogenic H-Ras at the immunological synapse.

PLoS ONE, 2007
Immune cells establish dynamic adhesive cell-cell interactions at a specific contact region, termed the immunological synapse (IS). Intriguing features of the IS are the formation of regions of plasma membrane fusion and the intercellular exchange of ...
Oded Rechavi, Itamar Goldstein, Helly Vernitsky, Barak Rotblat, Yoel Kloog   +4 more
doaj   +1 more source

Flotillins are involved in the polarization of primitive and mature hematopoietic cells.

PLoS ONE, 2009
BackgroundMigration of mature and immature leukocytes in response to chemokines is not only essential during inflammation and host defense, but also during development of the hematopoietic system.
Lawrence Rajendran, Julia Beckmann, Astrid Magenau, Eva-Maria Boneberg, Katharina Gaus, Antonella Viola, Bernd Giebel, Harald Illges   +7 more
doaj   +1 more source

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

Advanced Science, EarlyView.
Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y. Liu, Beibei Huang, Frank R. Rojas, Parra Cuentas. Edwin Roger, Ou Shi, Monique B. Nilsson, Alissa Poteete, Khaja B. Khan, Wei Lu, Luisa M. Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I. Wistuba, Zhubo Wei, Linghua Wang, Don L. Gibbons, Ken Chen, Alexandre Reuben, Jason M. Schenkel, John V. Heymach, Chao Cheng, Jia Wu, Jianjun Zhang   +34 more
wiley   +1 more source

Dendritic Cells and HIV-1 Trans-Infection

Viruses, 2010
Dendritic cells initiate and sustain immune responses by migrating to sites of pathogenic insult, transporting antigens to lymphoid tissues and signaling immune specific activation of T cells through the formation of the immunological synapse.
David McDonald
doaj   +1 more source

CD56 expression in breast cancer induces sensitivity to natural killer-mediated cytotoxicity by enhancing the formation of cytotoxic immunological synapse

Scientific Reports, 2019
We examined the potential value of the natural killer (NK) cell line; NK-92, as immunotherapy tool for breast cancer (BC) treatment and searched for biomarker(s) of sensitivity to NK-92-mediated cytotoxicity. The cytotoxic activity of NK-92 cells towards
Ghina Taouk, O. Hussein, Moussa Zekak, Ali Abouelghar, Y. Al-Sarraj, E. Abdelalim, Manale Karam   +6 more
semanticscholar   +1 more source

⁠Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells

Advanced Science, EarlyView.
This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley   +1 more source

Human T-cell receptor triggering requires inactivation of Lim kinase-1 by Slingshot-1 phosphatase

Communications Biology
Actin dynamics control early T-cell receptor (TCR) signalling during T-cell activation. However, the precise regulation of initial actin rearrangements is not completely understood.
Álvaro Gómez-Morón, Sergio Alegre-Gómez, Rocio Ramirez-Muñoz, Alicia Hernaiz-Esteban, Carlos Carrasco-Padilla, Camila Scagnetti, Óscar Aguilar-Sopeña, Marta García-Gil, Aldo Borroto, Raul Torres-Ruiz, Sandra Rodriguez-Perales, Francisco Sánchez-Madrid, Noa Beatriz Martín-Cófreces, Pedro Roda-Navarro   +13 more
doaj   +1 more source

Lymphocyte predominant cells of nodular lymphocyte predominant Hodgkin lymphoma interact with rosetting T cells in an immunological synapse [PDF]

, 2020
Julia Bein, Lorenz Thurner, Martin‐Leo Hansmann, Sylvia Hartmann   +3 more
openalex   +1 more source

Integrins Modulate T Cell Receptor Signaling by Constraining Actin Flow at the Immunological Synapse

Frontiers in Immunology, 2018
Full T cell activation requires coordination of signals from multiple receptor–ligand pairs that interact in parallel at a specialized cell–cell contact site termed the immunological synapse (IS).
Katarzyna I. Jankowska, E. Williamson, Nathan H. Roy, D. Blumenthal, Vidhi Chandra, T. Baumgart, J. Burkhardt   +6 more
semanticscholar   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source