Results 11 to 20 of about 491,336 (341)
The Actin Cytoskeleton at the Immunological Synapse of Dendritic Cells [PDF]
Frontiers in Cell and Developmental Biology, 2021 Dendritic cells (DCs) are considered the most potent antigen-presenting cells. DCs control the activation of T cells (TCs) in the lymph nodes. This process involves forming a specialized superstructure at the DC-TC contact zone called the immunological ...
José Luis Rodríguez-Fernández +1 more
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Orchestration of Immunological Synapse Assembly by Vesicular Trafficking [PDF]
Frontiers in Cell and Developmental Biology, 2019 Ligation of the T-cell antigen receptor (TCR) by cognate peptide bound to the Major Histocompatibility Complex on the surface of an antigen-presenting cell (APC) leads to the spatial reorganization of the TCR and accessory receptors to form a specialized
Anna Onnis, Cosima T. Baldari
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Actin clearance promotes polarized dynein accumulation at the immunological synapse. [PDF]
PLoS ONE, 2019 Immunological synapse (IS) formation between a T cell and an antigen-presenting cell is accompanied by the reorientation of the T cell centrosome toward the interface.
Elisa Sanchez, Xin Liu, Morgan Huse
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Cells, 2019 The immune system is a fundamental part of the tumor microenvironment. In particular, cytotoxic lymphocytes, such as cytolytic T cells and natural killer cells, control tumor growth and disease progression by interacting and eliminating tumor cells.
Hannah Wurzer +3 more
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Imaging the Human Immunological Synapse [PDF]
Journal of Visualized Experiments, 2019 The purpose of the method is to generate an immunological synapse (IS), an example of cell-to-cell conjugation formed by an antigen-presenting cell (APC) and an effector helper T lymphocyte (Th) cell, and to record the images corresponding to the first stages of the IS formation and the subsequent trafficking events (occurring both in the APC and in ...
Bello-Gamboa, Ana +8 more
openaire +6 more sources
Action and traction: cytoskeletal control of receptor triggering at the immunological synapse
Frontiers in Immunology, 2016 It is well known that F-actin dynamics drive micron-scale cell shape changes required for migration and immunological synapse formation. In addition, recent evidence points to a more intimate role for the actin cytoskeleton in promoting T cell activation.
Janis K. Burkhardt, William A Comrie
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Altered actin centripetal retrograde flow in physically restricted immunological synapses. [PDF]
PLoS ONE, 2010 Antigen recognition by T cells involves large scale spatial reorganization of numerous receptor, adhesion, and costimulatory proteins within the T cell-antigen presenting cell (APC) junction.
Cheng-han Yu +4 more
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Subdiffraction-resolution fluorescence imaging of immunological synapse formation between NK cells and A. fumigatus by expansion microscopy [PDF]
Communications Biology, 2021 Trinks et al developed a protocol that enables super-resolved visualisation of the interaction between natural killer cells and Aspergillus fumigatus hyphae by expansion microscopy.
Nora Trinks +6 more
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The dendritic cell side of the immunological synapse [PDF]
Biomolecular Concepts, 2016 Immune responses are initiated by the interactions between antigen-presenting cells (APCs), such as dendritic cells (DCs), with responder cells, such as T cells, via a tight cellular contact interface called the immunological synapse.
Verboogen Danielle R.J. +5 more
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Frontiers in Immunology, 2019 The chemokine receptor CCR7 guides T cells and dendritic cells to and within lymph nodes to launch the onset of adaptive immunity. Here, we demonstrate that CCR7 in addition acts as a potent co-stimulatory molecule in T cell activation.
Julia M. Laufer +7 more
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