Results 11 to 20 of about 19,459 (304)
An Effective Membrane Model of the Immunological Synapse [PDF]
Physical Review Letters, 2003 The immunological synapse is a patterned collection of different types of receptors and ligands that forms in the intercellular junction between T Cells and antigen presenting cells (APCs) during recognition. The synapse is implicated in information transfer between cells, and is characterized by different spatial patterns of receptors at different ...
Arup K. Chakraborty +3 more
arxiv +6 more sources
T cell stiffness is enhanced upon formation of immunological synapse [PDF]
eLife, 2021 T cells are activated by target cells via an intimate contact, termed immunological synapse (IS). Cellular mechanical properties, especially stiffness, are essential to regulate cell functions.
Philipp Jung +4 more
doaj +2 more sources
Actin Cytoskeleton Straddling the Immunological Synapse between Cytotoxic Lymphocytes and Cancer Cells [PDF]
Cells, 2019 The immune system is a fundamental part of the tumor microenvironment. In particular, cytotoxic lymphocytes, such as cytolytic T cells and natural killer cells, control tumor growth and disease progression by interacting and eliminating tumor cells.
Hannah Wurzer +3 more
doaj +2 more sources
Subdiffraction-resolution fluorescence imaging of immunological synapse formation between NK cells and A. fumigatus by expansion microscopy [PDF]
Communications Biology, 2021 Trinks et al developed a protocol that enables super-resolved visualisation of the interaction between natural killer cells and Aspergillus fumigatus hyphae by expansion microscopy.
Nora Trinks +6 more
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Orchestration of Immunological Synapse Assembly by Vesicular Trafficking [PDF]
Frontiers in Cell and Developmental Biology, 2019 Ligation of the T-cell antigen receptor (TCR) by cognate peptide bound to the Major Histocompatibility Complex on the surface of an antigen-presenting cell (APC) leads to the spatial reorganization of the TCR and accessory receptors to form a specialized
Anna Onnis, Cosima T. Baldari
doaj +2 more sources
Role of Drebrin at the Immunological Synapse. [PDF]
Adv Exp Med Biol, 2017 Although drebrin was first described in neurons, it is also expressed in cells of the immune system, such as T lymphocytes and mast cells. Another member of the drebrin family of proteins, mammalian actin-binding protein 1 (mAbp-1) is more widely expressed and plays important roles in the function of macrophages, polymorphonuclear neutrophils, and B ...
Rocha-Perugini V +2 more
europepmc +5 more sources
Intercellular transfer of oncogenic H-Ras at the immunological synapse.
PLoS ONE, 2007 Immune cells establish dynamic adhesive cell-cell interactions at a specific contact region, termed the immunological synapse (IS). Intriguing features of the IS are the formation of regions of plasma membrane fusion and the intercellular exchange of ...
Oded Rechavi +4 more
doaj +3 more sources
Comparative anatomy of phagocytic and immunological synapses [PDF]
Frontiers in Immunology, 2016 The generation of phagocytic cups and immunological synapses are crucial events of the innate and adaptive immune responses, respectively. They are triggered by distinct immune receptors and performed by different cell types.
Florence eNiedergang +2 more
doaj +6 more sources
Despite disorganized synapse structure, Th2 cells maintain directional delivery of CD40L to antigen-presenting B cells. [PDF]
PLoS ONE, 2017 Upon recognition of peptide displayed on MHC molecules, Th1 and Th2 cells form distinct immunological synapse structures. Th1 cells have a bull's eye synapse structure with TCR/ MHC-peptide interactions occurring central to a ring of adhesion molecules ...
Jennifer L Gardell, David C Parker
doaj +1 more source
Cytotoxic immunological synapses [PDF]
Immunological Reviews, 2010 Summary: One of the most fundamental activities of the adaptive immune system is to kill infected cells and tumor cells. Two distinct pathways mediate this process, both of which are facilitated by a cytotoxic immunological synapse. While traditionally thought of as innate immune cells, natural killer (NK) cells are now appreciated to have the ...
Dustin, M, Long, E
openaire +4 more sources