Dendritic cell actin dynamics control contact duration and priming efficiency at the immunological synapse. [PDF]
J Cell Biol, 2021 Dendritic cell (DC) actin dynamics at the immunological synapse with T cells is partially regulated by the WAVE regulatory complex. Absence of DC WAVE leads to reduced actin dynamics, prolonged cell–cell contacts, and impaired T cell priming.
Leithner A +8 more
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RBL-2H3 Mast Cell Receptor Dynamics in the Immunological Synapse [PDF]
Biophysica, 2022 The RBL-2H3 mast cell immunological synapse dynamics is often simulated with reaction–diffusion and Fokker–Planck equations. The equations focus on how the cell synapse captures receptors following an immune response, where the receptor capture at the ...
Ming Chih Tsai, Kathrin Spendier
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Developing T cells form an immunological synapse for passage through the β-selection checkpoint. [PDF]
J Cell Biol, 2021 During T cell development, genomic rearrangement must create a T cell receptor capable of transmitting signals. Allam et al. show that passage through the β-selection checkpoint requires the assembly of a platform to support TCR signaling, similar to the
Allam AH +3 more
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Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunological Synapse. [PDF]
Front Cell Dev Biol, 2021 T cell receptor (TCR) and B cell receptor (BCR) stimulation by antigen presented on an antigen-presenting cell (APC) induces the formation of the immune synapse (IS), the convergence of secretory vesicles from T and B lymphocytes toward the centrosome ...
Calvo V, Izquierdo M.
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Explainable machine learning for profiling the immunological synapse and functional characterization of therapeutic antibodies [PDF]
Nature Communications, 2023 Therapeutic antibodies are widely used to treat severe diseases. Most of them alter immune cells and act within the immunological synapse; an essential cell-to-cell interaction to direct the humoral immune response.
Sayedali Shetab Boushehri +8 more
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Cells, 2019 The immune system is a fundamental part of the tumor microenvironment. In particular, cytotoxic lymphocytes, such as cytolytic T cells and natural killer cells, control tumor growth and disease progression by interacting and eliminating tumor cells.
Hannah Wurzer +3 more
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CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD. [PDF]
PLoS Pathog, 2021 The Salmonella enterica effector SteD depletes mature MHC class II (mMHCII) molecules from the surface of infected antigen-presenting cells through ubiquitination of the cytoplasmic tail of the mMHCII β chain.
Cerny O +8 more
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Three-Dimensional Single Molecule Localization Microscopy Reveals the Topography of the Immunological Synapse at Isotropic Precision below 15 nm. [PDF]
Nano Lett, 2021 T-cells engage with antigen-presenting cells in search for antigenic peptides and form transient interfaces termed immunological synapses. Synapse topography affects receptor binding rates and the mutual segregation of proteins due to size exclusion ...
Velas L +7 more
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Connexin-Mediated Signaling at the Immunological Synapse. [PDF]
Int J Mol Sci, 2020 The immunological synapse (IS) is an intercellular communication platform, organized at the contact site of two adjacent cells, where at least one is an immune cell.
Tittarelli A +4 more
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Multiple actin networks coordinate mechanotransduction at the immunological synapse. [PDF]
J Cell Biol, 2020 T cell activation requires force production at the immunological synapse. Blumenthal and Burkhardt describe how distinct actin structures contribute to this process, addressing canonical immunological models from a mechanobiology perspective.
Blumenthal D, Burkhardt JK.
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