Results 21 to 30 of about 491,747 (317)

Immunological synapse formation between T regulatory cells and cancer-associated fibroblasts promotes tumour development [PDF]

Nature Communications
Cancer-associated fibroblasts (CAFs) have emerged as a dominant non-hematopoietic cell population in the tumour microenvironment, serving diverse functions in tumour progression.
Athina Varveri, Miranta Papadopoulou, Zacharias Papadovasilakis, Ewoud B. Compeer, Aigli-Ioanna Legaki, Anastasios Delis, Vasileia Damaskou, Louis Boon, Sevasti Papadogiorgaki, Martina Samiotaki, Periklis Foukas, Aristides G. Eliopoulos, Aikaterini Hatzioannou, Themis Alissafi, Michael L. Dustin, Panayotis Verginis   +15 more
openalex   +2 more sources

Orchestration of Immunological Synapse Assembly by Vesicular Trafficking

Frontiers in Cell and Developmental Biology, 2019
Ligation of the T-cell antigen receptor (TCR) by cognate peptide bound to the Major Histocompatibility Complex on the surface of an antigen-presenting cell (APC) leads to the spatial reorganization of the TCR and accessory receptors to form a specialized
Anna Onnis, Cosima T. Baldari
doaj   +2 more sources

Spatiotemporal Regulation of Signaling: Focus on T Cell Activation and the Immunological Synapse. [PDF]

Int J Mol Sci, 2020
In a signaling network, not only the functions of molecules are important but when (temporal) and where (spatial) those functions are exerted and orchestrated is what defines the signaling output.
Garcia E, Ismail S.
europepmc   +2 more sources

CD99-mediated immunological synapse formation potentiates CAR-T cell function [PDF]

Nature Communications
Despite the efficacy of chimeric antigen receptor (CAR)-T cells in selected hematological malignancies, further improvement on CAR-T designs is still desirable.
Giri Nam, Hye Ran Yeon, Hyung Bae Park, Hanna Chang, Ji Hwan Kim, Byoung-Kyu Cho, Hyeryeon Jung, Eugene C. Yi, Seoyeon Kim, Joon-Yong An, Ji Eun Lee, Youngjae Lee, Seoho Lee, Hyeonji Lim, Woo-Jeong Shon, Eun Mi Hwang, Hoon Ryu, Jun Chang, Kyungho Choi, Eun Young Choi   +19 more
doaj   +2 more sources

CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70

Frontiers in Immunology, 2019
The chemokine receptor CCR7 guides T cells and dendritic cells to and within lymph nodes to launch the onset of adaptive immunity. Here, we demonstrate that CCR7 in addition acts as a potent co-stimulatory molecule in T cell activation.
Julia M. Laufer, Julia M. Laufer, Ilona Kindinger, Marc Artinger, Marc Artinger, Andreas Pauli, Daniel F. Legler, Daniel F. Legler   +7 more
doaj   +2 more sources

Cx43-Gap Junctions Accumulate at the Cytotoxic Immunological Synapse Enabling Cytotoxic T Lymphocyte Melanoma Cell Killing [PDF]

International Journal of Molecular Sciences, 2019
Upon tumor antigen recognition, cytotoxic T lymphocytes (CTLs) and target cells form specialized supramolecular structures, called cytotoxic immunological synapses, which are required for polarized delivery of cytotoxic granules.
Francisca Hofmann, Mariela Navarrete, Javiera Álvarez, Israel Guerrero, María Alejandra Gleisner, Andrés Tittarelli, Flavio Salazar‐Onfray   +6 more
openalex   +2 more sources

Subdiffraction-resolution fluorescence imaging of immunological synapse formation between NK cells and A. fumigatus by expansion microscopy [PDF]

Communications Biology, 2021
Trinks et al developed a protocol that enables super-resolved visualisation of the interaction between natural killer cells and Aspergillus fumigatus hyphae by expansion microscopy.
Nora Trinks, Sebastian Reinhard, Matthias Drobny, Linda Heilig, Jürgen Löffler, Markus Sauer, Ulrich Terpitz   +6 more
doaj   +2 more sources

Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease [PDF]

Signal Transduction and Targeted Therapy
The immunological synapse (IS) serves as the fundamental architectural framework for direct interactions and secretory crosstalk between immune cells, as well as between immune cells and other cells.
Zheng Chao, Qi Mei, Chunguang Yang, Jing Luo, Peikun Liu, Hao Peng, Xiangdong Guo, Zhinan Yin, Le Li, Zhihua Wang   +9 more
doaj   +2 more sources

PDZ domains of PATJ facilitate immunological synapse formation to promote T cell activation. [PDF]

J Immunother Cancer
Xiong X, Wang D, Xu L, Chen S, He J, Zhang X, Fang Z, Zhang J, Li W, Zhou P.   +9 more
europepmc   +2 more sources

Imaging the Human Immunological Synapse. [PDF]

Journal of Visualized Experiments, 2019
The purpose of the method is to generate an immunological synapse (IS), an example of cell-to-cell conjugation formed by an antigen-presenting cell (APC) and an effector helper T lymphocyte (Th) cell, and to record the images corresponding to the first ...
Ana Bello-Gamboa, J. M. Izquierdo, Marta Velasco, Solange Moreno, A. Garrido, Laura Meyers, J. Palomino, V. Calvo, M. Izquierdo   +8 more
semanticscholar   +5 more sources