Mechanical Communication at the Immunological Synapse [PDF]
Trends in Cell Biology, 2017 T and B lymphocytes communicate by forming immunological synapses with antigen-presenting target cells. These highly dynamic contacts are characterized by continuous cytoskeletal remodeling events, which not only structure the interface but also exert a considerable amount of mechanical force.
Morgan Huse, Roshni Basu
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Intercellular transfer of oncogenic H-Ras at the immunological synapse.
PLoS ONE, 2007 Immune cells establish dynamic adhesive cell-cell interactions at a specific contact region, termed the immunological synapse (IS). Intriguing features of the IS are the formation of regions of plasma membrane fusion and the intercellular exchange of ...
Oded Rechavi +4 more
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An Effective Membrane Model of the Immunological Synapse [PDF]
Physical Review Letters, 2003 The immunological synapse is a patterned collection of different types of receptors and ligands that forms in the intercellular junction between T Cells and antigen presenting cells (APCs) during recognition.
Arup K. Chakraborty +8 more
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In vitro machine learning-based CAR T immunological synapse quality measurements correlate with patient clinical outcomes. [PDF]
PLoS Comput Biol, 2022 The human immune system consists of a highly intelligent network of billions of independent, self-organized cells that interact with each other. Machine learning (ML) is an artificial intelligence (AI) tool that automatically processes huge amounts of ...
Naghizadeh A +9 more
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Chemokines and the immunological synapse
Immunology, 2002 The critical event which initiates an adaptive immune response is the interaction of T cells through the T-cell antigen receptor (TCR) with major histocompatibility complex (MHC)–peptide (MHCp) complexes on the surface of antigen-presenting cells (APCs).
Victor L. J. Tybulewicz
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Comparative anatomy of phagocytic and immunological synapses [PDF]
Frontiers in Immunology, 2016 The generation of phagocytic cups and immunological synapses are crucial events of the innate and adaptive immune responses, respectively. They are triggered by distinct immune receptors and performed by different cell types.
Florence eNiedergang +2 more
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Developing T cells form an immunological synapse for passage through the β-selection checkpoint. [PDF]
J Cell Biol, 2021 During T cell development, genomic rearrangement must create a T cell receptor capable of transmitting signals. Allam et al. show that passage through the β-selection checkpoint requires the assembly of a platform to support TCR signaling, similar to the
Allam AH +3 more
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Dendritic cell actin dynamics control contact duration and priming efficiency at the immunological synapse. [PDF]
J Cell Biol, 2021 Dendritic cell (DC) actin dynamics at the immunological synapse with T cells is partially regulated by the WAVE regulatory complex. Absence of DC WAVE leads to reduced actin dynamics, prolonged cell–cell contacts, and impaired T cell priming.
Leithner A +8 more
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Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunological Synapse. [PDF]
Front Cell Dev Biol, 2021 T cell receptor (TCR) and B cell receptor (BCR) stimulation by antigen presented on an antigen-presenting cell (APC) induces the formation of the immune synapse (IS), the convergence of secretory vesicles from T and B lymphocytes toward the centrosome ...
Calvo V, Izquierdo M.
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Three-Dimensional Single Molecule Localization Microscopy Reveals the Topography of the Immunological Synapse at Isotropic Precision below 15 nm. [PDF]
Nano Lett, 2021 T-cells engage with antigen-presenting cells in search for antigenic peptides and form transient interfaces termed immunological synapses. Synapse topography affects receptor binding rates and the mutual segregation of proteins due to size exclusion ...
Velas L +7 more
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