Results 31 to 40 of about 19,457 (207)

HIV-1 intersection with CD4 T cell vesicle exocytosis: intercellular communication goes viral

Frontiers in Immunology, 2014
In cells of the immune system the secretion of extracellular vesicles is modulated through cellular activation. In particular, T cell activation is achieved through cell-cell contacts with antigen presenting cells and the consequent formation of a ...
Helena eSoares, Helena eSoares
doaj   +1 more source

T cells' immunological synapses induce polarization of brain astrocytes in vivo and in vitro: a novel astrocyte response mechanism to cellular injury. [PDF]

PLoS ONE, 2008
Astrocytes usually respond to trauma, stroke, or neurodegeneration by undergoing cellular hypertrophy, yet, their response to a specific immune attack by T cells is poorly understood.
Carlos Barcia, Nicholas S R Sanderson, Robert J Barrett, Kolja Wawrowsky, Kurt M Kroeger, Mariana Puntel, Chunyan Liu, Maria G Castro, Pedro R Lowenstein   +8 more
doaj   +1 more source

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse

Viruses, 2010
The virological synapse (VS) is a tight adhesive junction between an HIV-infected cell and an uninfected target cell, across which virus can be efficiently transferred from cell to cell in the absence of cell-cell fusion.
Gaia Vasiliver-Shamis, Michael L. Dustin, Catarina E. Hioe   +2 more
doaj   +1 more source

Close Contact Fluctuations: Time of Contact [PDF]

Physical Review E 90, 042706 (2014), 2014
The letter resolves the long standing debate as to the proper time scale ($<\tau>$) of the onset of the immunological synapse (IS) bond, the non-covalent chemical bond defining the immune pathways involving T-cells and antigen presenting cells (APC).
arxiv   +1 more source

Active tuning of synaptic patterns enhances immune discrimination [PDF]

Phys. Rev. Lett. 121, 238101 (2018), 2018
Immune cells learn about their antigenic targets using tactile sense: during recognition, a highly organized yet dynamic motif, named immunological synapse, forms between immune cells and antigen-presenting cells (APCs). Via synapses, immune cells selectively extract recognized antigen from APCs by applying mechanical pulling forces generated by the ...
arxiv   +1 more source

Circadian modulation of microglial physiological processes and immune responses

Glia, Volume 71, Issue 2, Page 155-167, February 2023., 2023
Main Points Microglia are rhythmic cells with an oscillatory expression in clock genes, cytokines, and other microglial markers. Microglial circadian rhythms determine their physiological function and immune responses. Abstract Microglia is considered the central nervous system (CNS) resident macrophages that establish an innate immune response against
Mara A. Guzmán‐Ruiz, Natalí N. Guerrero‐Vargas, Alejandra Lagunes‐Cruz, Shellye González‐González, Jesús Enrique García‐Aviles, Gabriela Hurtado‐Alvarado, Rebeca Mendez‐Hernández, Anahí Chavarría‐Krauser, Jean‐Pascal Morin, Virginia Arriaga‐Avila, Ruud M. Buijs, Rosalinda Guevara‐Guzmán   +11 more
wiley   +1 more source

The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection

Nature Communications, 2022
HIV infection over time is thought to result in premature aging and aberrant immune responses including the induction of immunological senescence. Here the authors show altered formation of immune synapses by naive CD8+ T cells and dysregulated synapse ...
Nadia Anikeeva, Maria Steblyanko, Leticia Kuri-Cervantes, Marcus Buggert, Michael R. Betts, Yuri Sykulev   +5 more
doaj   +1 more source

Stochastic model of T Cell repolarization during target elimination (I) [PDF]

, 2020
Cytotoxic T lymphocytes (T) and natural killer (NK) cells are the main cytotoxic killer cells of the human body to eliminate pathogen-infected or tumorigenic cells (i.e. target cells). Once a NK or T cell has identified a target cell, they form a tight contact zone, the immunological synapse (IS).
arxiv   +1 more source

Is microglial dystrophy a form of cellular senescence? An analysis of senescence markers in the aged human brain

Glia, Volume 71, Issue 2, Page 377-390, February 2023., 2023
Main Points Aging‐related morphological changes in microglia (dystrophy) do not correlate with expression of universal senescence markers. Microglial dystrophy coincides with an aging‐related increase in microglial ferritin expression. Abstract Aging can cause morphological transformation in human microglia indicative of cell senescence, termed ...
Pauline Neumann, Dana E. Lenz, Wolfgang J. Streit, Ingo Bechmann   +3 more
wiley   +1 more source