Results 31 to 40 of about 40,449 (200)

Actin Cytoskeleton Straddling the Immunological Synapse between Cytotoxic Lymphocytes and Cancer Cells

Cells, 2019
The immune system is a fundamental part of the tumor microenvironment. In particular, cytotoxic lymphocytes, such as cytolytic T cells and natural killer cells, control tumor growth and disease progression by interacting and eliminating tumor cells.
Hannah Wurzer, Céline Hoffmann, Antoun Al Absi, Clément Thomas   +3 more
doaj   +1 more source

Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes

Nature Communications, 2022
Cytotoxic T cells have specialised granules that are important for mediating their killing function. Here the authors characterise two types of cytotoxic granules and indicate different functions and temporal release of mediators at the immunological ...
Hsin-Fang Chang, Claudia Schirra, Momchil Ninov, Ulrike Hahn, Keerthana Ravichandran, Elmar Krause, Ute Becherer, Štefan Bálint, Maria Harkiolaki, Henning Urlaub, Salvatore Valitutti, Cosima T. Baldari, Michael L. Dustin, Reinhard Jahn, Jens Rettig   +14 more
doaj   +1 more source

The Wiskott-Aldrich syndrome protein permits assembly of a focused immunological synapse enabling sustained T-cell receptor signaling

Haematologica, 2011
Background T-cell activation relies on the assembly of the immunological synapse, a structure tightly regulated by the actin cytoskeleton. The precise role of the Wiskott-Aldrich syndrome protein, an actin cytoskeleton regulator, in linking immunological
Ronan Calvez, Fanny Lafouresse, Julie De Meester, Anne Galy, Salvatore Valitutti, Loïc Dupré   +5 more
doaj   +1 more source

Altered actin centripetal retrograde flow in physically restricted immunological synapses. [PDF]

PLoS ONE, 2010
Antigen recognition by T cells involves large scale spatial reorganization of numerous receptor, adhesion, and costimulatory proteins within the T cell-antigen presenting cell (APC) junction.
Cheng-han Yu, Hung-jen Wu, Yoshihisa Kaizuka, Ronald D Vale, Jay T Groves   +4 more
doaj   +1 more source

Mechanisms of pattern formation during T cell adhesion [PDF]

, 2004
T cells form intriguing patterns during adhesion to antigen-presenting cells. The patterns at the cell-cell contact zone are composed of two types of domains, which either contain short TCR/MHCp receptor-ligand complexes or the longer LFA-1/ICAM-1 ...
Alberts, Allenspach, Almeida, Bell, Binder, Brochard, Bromley, Brown, Burack, Burroughs, Chen, Coombs, Davis, Davis, Delon, Delon, Dietrich, Dustin, Dustin, Dustin, Dustin, Dustin, Fassett, Friedl, Grakoui, Gunzer, Hailman, Janes, Janes, Johnson, Krummel, Kusumi, Lee, Lee, Lee, Lee, Lollo, Mehta, Mempel, Monks, Orsello, Potter, Pralle, Qi, Raychaudhuri, Richie, Seifert, Sharma, Shaw, Simons, Simons, Simson, van der Merwe, van Kampen, Viola, Weikl, Wülfing, Wülfing, Zhang   +58 more
core   +4 more sources

The dendritic cell side of the immunological synapse

Biomolecular Concepts, 2016
Immune responses are initiated by the interactions between antigen-presenting cells (APCs), such as dendritic cells (DCs), with responder cells, such as T cells, via a tight cellular contact interface called the immunological synapse.
Verboogen Danielle R.J., Dingjan Ilse, Revelo Natalia H., Visser Linda J., ter Beest Martin, van den Bogaart Geert   +5 more
doaj   +1 more source

Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse [PDF]

, 2002
Receptor-ligand couples in the cell-cell contact interface between a T cell and an antigen-presenting cell form distinct geometric patterns and undergo spatial rearrangement within the contact interface.
Alon, Bell, Bell, Bromley, Brown, Carlin, Christoph Wülfing, Dai, Davis, Dembo, Donnadieu, Dustin, Dustin, Dustin, Evans, Favier, Forscher, Fritz, Grakoui, Hahn, Janes, Janeway, Johnson, Johnson, Krummel, Lauffenburger, Le Grimellec, Leupin, Lollo, Lyons, McNeill, Monks, Moy, Needham, Nigel John Burroughs, Orsello, Pathria, Pierres, Qi, Raucher, Raucher, Rotsch, Rudd, Ryan, Schreiner, Shao, Simons, Strey, Taylor, van der Merwe, Viola, Wild, Wülfing, Wülfing, Wülfing   +54 more
core   +2 more sources

Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL

eLife, 2014
T cell receptor (TCR) activation leads to a dramatic reorganisation of both membranes and receptors as the immunological synapse forms. Using a genetic model to rapidly inhibit Zap70 catalytic activity we examined synapse formation between cytotoxic T ...
Misty R Jenkins, Jane C Stinchcombe, Byron B Au-Yeung, Yukako Asano, Alex T Ritter, Arthur Weiss, Gillian M Griffiths   +6 more
doaj   +1 more source

Close contact fluctuations: the seeding of signalling domains in the immunological synapse [PDF]

Europhysics Letters 77, 48003 (2007), 2006
We analyse the size and density of thermally induced regions of close contact in cell:cell contact interfaces within a harmonic potential approximation, estimating these regions to be below one-tenth of a micron across. Our calculations indicate that as the distance between the close contact threshold depth and the mean membrane-membrane separation ...
arxiv   +1 more source

Action and traction: cytoskeletal control of receptor triggering at the immunological synapse

Frontiers in Immunology, 2016
It is well known that F-actin dynamics drive micron-scale cell shape changes required for migration and immunological synapse formation. In addition, recent evidence points to a more intimate role for the actin cytoskeleton in promoting T cell activation.
Janis K. Burkhardt, William A Comrie
doaj   +1 more source