Results 31 to 40 of about 491,747 (317)
Comparative anatomy of phagocytic and immunological synapses [PDF]
Frontiers in Immunology, 2016 The generation of phagocytic cups and immunological synapses are crucial events of the innate and adaptive immune responses, respectively. They are triggered by distinct immune receptors and performed by different cell types.
Florence eNiedergang +2 more
doaj +4 more sources
NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse
Nature Immunology, 2023 The formation of an immunological synapse (IS) is essential for natural killer (NK) cells to eliminate target cells. Despite an advanced understanding of the characteristics of the IS and its formation processes, the mechanisms that regulate its ...
Se-Chan Oh +11 more
semanticscholar +1 more source
Cell polarisation and the immunological synapse
Current Opinion in Cell Biology, 2012 Directed secretion by immune cells requires formation of the immunological synapse at the site of cell-cell contact, concomitant with a dramatic induction of cell polarity. Recent findings provide us with insights into the various steps that are required for these processes: for example, the first identification of a protein at the centrosome that ...
Karen L. Angus, Gillian M. Griffiths
openalex +3 more sources
Cytotoxic immunological synapses [PDF]
Immunological Reviews, 2010 Summary: One of the most fundamental activities of the adaptive immune system is to kill infected cells and tumor cells. Two distinct pathways mediate this process, both of which are facilitated by a cytotoxic immunological synapse. While traditionally thought of as innate immune cells, natural killer (NK) cells are now appreciated to have the ...
Dustin, M, Long, E
openaire +3 more sources
Despite disorganized synapse structure, Th2 cells maintain directional delivery of CD40L to antigen-presenting B cells. [PDF]
PLoS ONE, 2017 Upon recognition of peptide displayed on MHC molecules, Th1 and Th2 cells form distinct immunological synapse structures. Th1 cells have a bull's eye synapse structure with TCR/ MHC-peptide interactions occurring central to a ring of adhesion molecules ...
Jennifer L Gardell, David C Parker
doaj +1 more source
bioRxiv, 2022 Ligation of the T cell receptor (TCR) to peptide-MHC complexes initiates signaling leading to T cell activation. Regulation of T cell responses also requires mechanisms to stop this signaling and to downregulate surface expression of the receptor.
Audun Kvalvaag +6 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2021 Natural killer (NK) cells are innate lymphoid cells, which play key roles in elimination of virally infected and malignant cells. The balance between activating and inhibitory signals derived from NK surface receptors govern the NK cell immune response ...
Aviad Ben-Shmuel +3 more
doaj +1 more source
Checkpoint Genes at the Cancer Side of the Immunological Synapse in Bladder Cancer. [PDF]
Transl Oncol, 2020 Dobosz P +8 more
europepmc +2 more sources
Frontiers in Immunology, 2022 Hemichannels (HCs)/gap junctions (GJs) and immunoglobulin (Ig)-like domain-containing proteins (IGLDCPs) are involved in the innate–adaptive immune response independently.
Jiang-Hui Meng +8 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 A central process in immunity is the activation of T cells through interaction of T cell receptors (TCRs) with agonistic peptide-major histocompatibility complexes (pMHC) on the surface of antigen presenting cells (APCs).
J. Felce +11 more
semanticscholar +1 more source