Results 41 to 50 of about 19,459 (304)
RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling. [PDF]
PLoS ONE, 2010 RhoH is an hematopoietic-specific, GTPase-deficient Rho GTPase that plays a role in T development. We investigated the mechanisms of RhoH function in TCR signaling. We found that the association between Lck and CD3ζ was impaired in RhoH-deficient T cells,
Hee-Don Chae +4 more
doaj +1 more source
The role of the cytoskeleton at the immunological synapse [PDF]
Immunological Reviews, 2013 SummaryIt has been over 30 years since the reorganization of both the microtubule network and a ‘peculiar actin polarization’ was reported at the contact area of cytotoxic T lymphocytes interacting with target cells. Since that time, hundreds of studies have been published in an effort to elucidate the structure and function of the microtubule network ...
Karen L. Angus +2 more
openaire +3 more sources
Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica +6 more
wiley +1 more source
In vitro Assessment of Immunological Synapse Formation by Flow Cytometry
Bio-Protocol, 2016 In adaptive immune system, formation of immunological synapse between T cells and antigen presenting cells (dendritic cells, B cells, and macrophages) or target cells (tumor cells and viral-infected cells) is critical for the execution of T cell immune ...
Bo-Ra Na, Chang-Duk Jun
doaj +1 more source
Immunological Synapse in the Biology of Chronic Lymphocytic Leukemia [PDF]
Клиническая онкогематология, 2018 Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disease manifested by accumulation of tumor B-cells with characteristic immunophenotype (CD19+CD5+CD23+) in bone marrow, peripheral blood and secondary lymphoid organs.
DS Badmazhapova +2 more
doaj +1 more source
Stochastic model of T Cell repolarization during target elimination (II) [PDF]
, 2021 Cytotoxic T lymphocytes (T cells) and natural killer cells form a tight contact, the immunological synapse (IS), with target cells, where they release their lytic granules containing perforin/granzyme and cytokine containing vesicles. During this process the cell repolarizes and moves the microtubule organizing center (MTOC) towards the IS.
arxiv +1 more source
What is the importance of the immunological synapse? [PDF]
Trends in Immunology, 2004 The immunological synapse (IS) has proved to be a stimulating concept, particularly in provoking discussion on the similarity of intercellular communication controlling disparate biological processes. Recent studies have clarified some of the underlying molecular mechanisms and functions of the IS.
Davis, Daniel M., Dustin, Michael L.
openaire +4 more sources
HIV-1 intersection with CD4 T cell vesicle exocytosis: intercellular communication goes viral
Frontiers in Immunology, 2014 In cells of the immune system the secretion of extracellular vesicles is modulated through cellular activation. In particular, T cell activation is achieved through cell-cell contacts with antigen presenting cells and the consequent formation of a ...
Helena eSoares, Helena eSoares
doaj +1 more source
Communication, the centrosome and the immunological synapse [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 Recent findings on the behaviour of the centrosome at the immunological synapse suggest a critical role for centrosome polarization in controlling the communication between immune cells required to generate an effective immune response. The features observed at the immunological synapse show parallels to centrosome (basal body) polarization seen in ...
Gillian M. Griffiths +1 more
openaire +3 more sources
Circadian modulation of microglial physiological processes and immune responses
Glia, Volume 71, Issue 2, Page 155-167, February 2023., 2023 Main Points Microglia are rhythmic cells with an oscillatory expression in clock genes, cytokines, and other microglial markers. Microglial circadian rhythms determine their physiological function and immune responses. Abstract Microglia is considered the central nervous system (CNS) resident macrophages that establish an innate immune response against
Mara A. Guzmán‐Ruiz +11 more
wiley +1 more source