Results 41 to 50 of about 491,336 (341)

Single-Molecule, Super-Resolution, and Functional Analysis of G Protein-Coupled Receptor Behavior Within the T Cell Immunological Synapse

Frontiers in Cell and Developmental Biology, 2021
A central process in immunity is the activation of T cells through interaction of T cell receptors (TCRs) with agonistic peptide-major histocompatibility complexes (pMHC) on the surface of antigen presenting cells (APCs).
J. Felce, L. Parolini, E. Sezgin, P. Céspedes, K. Korobchevskaya, Mathew Jones, Yanchun Peng, T. Dong, M. Fritzsche, Dirk Aarts, J. Frater, Michael Loran Dustin   +11 more
semanticscholar   +1 more source

Cross-Activation of Hemichannels/Gap Junctions and Immunoglobulin-Like Domains in Innate–Adaptive Immune Responses

Frontiers in Immunology, 2022
Hemichannels (HCs)/gap junctions (GJs) and immunoglobulin (Ig)-like domain-containing proteins (IGLDCPs) are involved in the innate–adaptive immune response independently.
Jiang-Hui Meng, Jiang-Hui Meng, Chang-Xu Chen, Chang-Xu Chen, Mohammad R. Ahmadian, Hong Zan, Kai-Jun Luo, Kai-Jun Luo, Jean X. Jiang   +8 more
doaj   +1 more source

The diversity of immunological synapses [PDF]

Current Opinion in Immunology, 2003
Immunological synapses (ISs) are specialised signalling domains characterised by complex molecular clustering and segregation at the contact site between cells of the immune system. T lymphocytes form different ISs depending on their state of activation and on the antigen-presenting cells with which they interact. The structural features of the various
Alain Trautmann, Salvatore Valitutti
openaire   +4 more sources

DISC1 is needed for the organization of cellular components at the immunological synapse. [PDF]

, 2019
T-cells carry out their immune functions through receptor-based recognition and adhesion to target cells. The cell-cell junction that is created from this connection is known as the immunological synapse (IS); a cellular structure composed of organized ...
Ramakrishnan, Adarsh
core   +1 more source

The Immunological Synapse [PDF]

Cancer Immunology Research, 2003
AbstractThe molecular interactions underlying regulation of the immune response take place in a nanoscale gap between T cells and antigen-presenting cells, termed the immunological synapse. If these interactions are regulated appropriately, the host is defended against a wide range of pathogens and deranged host cells.
openaire   +8 more sources

The Immunological Synapse

Annual Review of Immunology, 2001
The adaptive immune response is initiated by the interaction of T cell antigen receptors with major histocompatibility complex molecule-peptide complexes in the nanometer scale gap between a T cell and an antigen-presenting cell, referred to as an immunological synapse.
Bromley, S, Burack, W, Johnson, K, Somersalo, K, Sims, T, Sumen, C, Davis, M, Shaw, A, Allen, P, Dustin, M   +9 more
openaire   +4 more sources

The Wiskott-Aldrich syndrome protein permits assembly of a focused immunological synapse enabling sustained T-cell receptor signaling

Haematologica, 2011
Background T-cell activation relies on the assembly of the immunological synapse, a structure tightly regulated by the actin cytoskeleton. The precise role of the Wiskott-Aldrich syndrome protein, an actin cytoskeleton regulator, in linking immunological
Ronan Calvez, Fanny Lafouresse, Julie De Meester, Anne Galy, Salvatore Valitutti, Loïc Dupré   +5 more
doaj   +1 more source

Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes

Nature Communications, 2022
Cytotoxic T cells have specialised granules that are important for mediating their killing function. Here the authors characterise two types of cytotoxic granules and indicate different functions and temporal release of mediators at the immunological ...
Hsin-Fang Chang, Claudia Schirra, Momchil Ninov, Ulrike Hahn, Keerthana Ravichandran, Elmar Krause, Ute Becherer, Štefan Bálint, Maria Harkiolaki, Henning Urlaub, Salvatore Valitutti, Cosima T. Baldari, Michael L. Dustin, Reinhard Jahn, Jens Rettig   +14 more
doaj   +1 more source

Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse [PDF]

, 2002
Receptor-ligand couples in the cell-cell contact interface between a T cell and an antigen-presenting cell form distinct geometric patterns and undergo spatial rearrangement within the contact interface.
Alon, Bell, Bell, Bromley, Brown, Carlin, Christoph Wülfing, Dai, Davis, Dembo, Donnadieu, Dustin, Dustin, Dustin, Evans, Favier, Forscher, Fritz, Grakoui, Hahn, Janes, Janeway, Johnson, Johnson, Krummel, Lauffenburger, Le Grimellec, Leupin, Lollo, Lyons, McNeill, Monks, Moy, Needham, Nigel John Burroughs, Orsello, Pathria, Pierres, Qi, Raucher, Raucher, Rotsch, Rudd, Ryan, Schreiner, Shao, Simons, Strey, Taylor, van der Merwe, Viola, Wild, Wülfing, Wülfing, Wülfing   +54 more
core   +2 more sources

Rosetting T cells in Hodgkin lymphoma are activated by immunological synapse components HLA class II and CD58.

Blood, 2020
A unique feature of Hodgkin lymphoma (HL) is the presence of CD4+ T cells that surround, protect and promote survival of tumor cells. The adhesion molecules involved in this so-called T cell rosetting are important components of the immunological synapse
Veldman J, Visser L, Huberts-Kregel M, Muller N, Hepkema B, van den Berg A, Diepstra A.   +6 more
europepmc   +2 more sources