Results 51 to 60 of about 491,747 (317)
RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling. [PDF]
PLoS ONE, 2010 RhoH is an hematopoietic-specific, GTPase-deficient Rho GTPase that plays a role in T development. We investigated the mechanisms of RhoH function in TCR signaling. We found that the association between Lck and CD3ζ was impaired in RhoH-deficient T cells,
Hee-Don Chae +4 more
doaj +1 more source
HIV-1 intersection with CD4 T cell vesicle exocytosis: intercellular communication goes viral
Frontiers in Immunology, 2014 In cells of the immune system the secretion of extracellular vesicles is modulated through cellular activation. In particular, T cell activation is achieved through cell-cell contacts with antigen presenting cells and the consequent formation of a ...
Helena eSoares, Helena eSoares
doaj +1 more source
HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse
Viruses, 2010 The virological synapse (VS) is a tight adhesive junction between an HIV-infected cell and an uninfected target cell, across which virus can be efficiently transferred from cell to cell in the absence of cell-cell fusion.
Gaia Vasiliver-Shamis +2 more
doaj +1 more source
Blood, 2020 A unique feature of Hodgkin lymphoma (HL) is the presence of CD4+ T cells that surround, protect and promote survival of tumor cells. The adhesion molecules involved in this so-called T cell rosetting are important components of the immunological synapse
J. Veldman +6 more
semanticscholar +1 more source
Actin Engine in Immunological Synapse [PDF]
Immune Network, 2012 T cell activation and function require physical contact with antigen presenting cells at a specialized junctional structure known as the immunological synapse. Once formed, the immunological synapse leads to sustained T cell receptor-mediated signalling and stabilized adhesion.
Piragyte, Indre, Jun, Chang-Duk
openaire +2 more sources
T lymphocyte myosin IIA is required for maturation of the immunological synapse
Frontiers in Immunology, 2012 The role of non-muscle myosin IIA (heavy chain encoded by the non-muscle myosin heavy chain 9 gene, Myh9) in immunological synapse formation is controversial.
Sudha eKumari +6 more
doaj +1 more source
Information transfer at the immunological synapse [PDF]
Current Biology, 2000 Antigen-specific activation of T lymphocytes requires the interaction of their clonally distributed T-cell receptors with plasma membrane ligands composed of foreign peptide antigens bound to major histocompatibility complex molecules. For proliferation and differentiation to ensue, a variety of other adhesive and accessory proteins must also interact ...
Jérôme Delon, Ronald N. Germain
openalex +3 more sources
The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection
Nature Communications, 2022 HIV infection over time is thought to result in premature aging and aberrant immune responses including the induction of immunological senescence. Here the authors show altered formation of immune synapses by naive CD8+ T cells and dysregulated synapse ...
Nadia Anikeeva +5 more
doaj +1 more source
Altered actin centripetal retrograde flow in physically restricted immunological synapses.
PLoS ONE, 2010 Antigen recognition by T cells involves large scale spatial reorganization of numerous receptor, adhesion, and costimulatory proteins within the T cell-antigen presenting cell (APC) junction.
Cheng-han Yu +4 more
doaj +1 more source
eLife, 2015 Wiscott Aldrich Syndrome protein (WASP) deficiency results in defects in calcium ion signaling, cytoskeletal regulation, gene transcription and overall T cell activation. The activation of WASP constitutes a key pathway for actin filament nucleation. Yet,
Sudha Kumari +10 more
doaj +1 more source