Results 61 to 70 of about 40,449 (200)

Modulation of Host Immunity by Human Respiratory Syncytial Virus Virulence Factors: A Synergic Inhibition of Both Innate and Adaptive Immunity [PDF]

, 2017
Indexación: Web of Science; Scopus.The Human Respiratory Syncytial Virus (hRSV) is a major cause of acute lower respiratory tract infections (ARTIs) and high rates of hospitalizations in children and in the elderly worldwide.
Acevedo-Acevedo, O., Bueno, S.M., Canedo-Marroquín, G., Kalergis, A.M., Lay, M.K., Rey-Jurado, E., Riedel, C.A., Saavedra, J.M.   +7 more
core   +1 more source

Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. [PDF]

, 2011
Innate immune cells must be able to distinguish between direct binding to microbes and detection of components shed from the surface of microbes located at a distance. Dectin-1 (also known as CLEC7A) is a pattern-recognition receptor expressed by myeloid
AM Kerrigan, AM Kerrigan, Andrea J. Wolf, Andrew S. Magee, Anissa S. H. Chan, Arthur Weiss, B Ferwerda, BN Gantner, Christopher N. Reyes, Courtney A. Becker, D Feng, David M. Underhill, DM Underhill, DR Fooksman, EL Adams, GD Brown, GD Brown, GL Fuller, Helen S. Goodridge, HS Goodridge, HS Goodridge, HS Goodridge, J Lin, JK Czop, John P. Vasilakos, Jun Ma, JW Zhu, KM Dennehy, LM Lavigne, Michael E. Danielson, MJ Robinson, ML Hermiston, Nandita Bose, PR Taylor, S Saijo, Tamiko R. Katsumoto, TS Plantinga   +36 more
core   +5 more sources

HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells [PDF]

, 2014
Immune evasion genes help human cytomegalovirus (HCMV) establish lifelong persistence. Without immune pressure, laboratory-adapted HCMV strains have undergone genetic alterations.
Aicheler, Andrew J. Davison, Arnon, Benedict, Bentz, Billadeau, Borivoj Vojtesek, Brown, Butler, Cerboni, Chapman, Dargan, Davis, Eddie C.Y. Wang, Evans, Fielding, Gavin S. Wilkie, Gavin W.G. Wilkinson, Gross, Humphries, Jürgen Haas, Kelly L. Miners, Kim, Le, Mace, Marco A. Purbhoo, Marcus Heinzmann, Melanie Moore, Michael P. Weekes, Morris, Orange, Paul J. Lehner, Penfold, Peter Tomasec, Prod’homme, Prod’homme, Prod’homme, Rak, Rebecca J. Aicheler, Richard J. Stanton, Riedl, Robin Antrobus, Ryu, Seo, Smith, Stanton, Stanton, Stanton, Stephen Man, Striebinger, Susanne M. Bailer, Takenawa, Tani, Taylor, Tomasec, Tomasec, Umashankar, Virginie Prod’homme, Wang, Weekes, Wilkinson   +60 more
core   +3 more sources

Actin depletion initiates events leading to granule secretion at the immunological synapse. [PDF]

, 2015
Cytotoxic T lymphocytes (CTLs) use polarized secretion to rapidly destroy virally infected and tumor cells. To understand the temporal relationships between key events leading to secretion, we used high-resolution 4D imaging. CTLs approached targets with

core   +1 more source

High-Resolution Imaging of Natural Killer Cell Immunological Synapses

, 2011
The first observations of the immunological synapse have demonstrated that immune-cell signalling in situ does not simply depend on protein structures and signalling pathways but also on temporal and spatial coordinates. With the advent of new live-cell,
Oddos, Stephane, Oddos, Stephane
core   +1 more source

A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion

Nature Communications, 2016
Galectin-3 is a sugar-binding protein that can inhibit antitumour cytotoxic immunity. Here the authors show that Galectin-3 expressed by tumour cells inhibits LFA-1 on cytotoxic lymphocytes, impairing immunological synapse formation, IFNg secretion, and ...
Anne-Elisabeth Petit, Nathalie Demotte, Benoît Scheid, Claude Wildmann, René Bigirimana, Monica Gordon-Alonso, Javier Carrasco, Salvatore Valitutti, Danièle Godelaine, Pierre van der Bruggen   +9 more
doaj   +1 more source

Geometrically repatterned immunological synapses uncover formation mechanisms. [PDF]

PLoS Computational Biology, 2006
The interaction of T cells and antigen-presenting cells is central to adaptive immunity and involves the formation of immunological synapses in many cases.
Marc Thilo Figge, Michael Meyer-Hermann
doaj   +1 more source

The combined effect of chemical and electrical synapses in small Hindmarsch-Rose neural networks on synchronisation and on the rate of information [PDF]

Phys. Rev. E, vol. 82, 036203 (2010), 2009
In this work we studied the combined action of chemical and electrical synapses in small networks of Hindmarsh-Rose (HR) neurons on the synchronous behaviour and on the rate of information produced (per time unit) by the networks. We show that if the chemical synapse is excitatory, the larger the chemical synapse strength used the smaller the ...
arxiv   +1 more source

T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles

Nature Communications, 2022
T cells communicate with antigen-presenting cells (APC) via the signaling crosstalk at the immunological synapse (IS). Here the authors use bead-supported lipid bilayers as synthetic APCs to find that trans-synaptic vesicles produced by T cells in the IS
Pablo F. Céspedes, Ashwin Jainarayanan, Lola Fernández-Messina, Salvatore Valvo, David G. Saliba, Elke Kurz, Audun Kvalvaag, Lina Chen, Charity Ganskow, Huw Colin-York, Marco Fritzsche, Yanchun Peng, Tao Dong, Errin Johnson, Jesús A. Siller-Farfán, Omer Dushek, Erdinc Sezgin, Ben Peacock, Alice Law, Dimitri Aubert, Simon Engledow, Moustafa Attar, Svenja Hester, Roman Fischer, Francisco Sánchez-Madrid, Michael L. Dustin   +25 more
doaj   +1 more source

Stomatin-like Protein 2 Links Mitochondria to T-Cell Receptor Signalosomes at the Immunological Synapse and Enhances T-Cell Activation [PDF]

, 2007
T cell activation through the antigen receptor (TCR) requires sustained signalling from microclusters in the peripheral region of the immunological synapse (IS).
Caitlin D. Lemke, Isaac Blaca, Joaquin Madrenas, Kamilia Rizkalla, Luan A. Chau, Maria E. Marquez, Mark G. Kirchhof, Michael L. Dustin, Peter J. Darlington, Roy Taylor, Santosh Vardhana   +10 more
core   +1 more source