Results 1 to 10 of about 10,277 (200)

Comparison of two immunotoxins against DLL3 receptor; as an inhibitor for small cell lung cancer [PDF]

Frontiers in Molecular Biosciences
Despite the efforts of researchers to develop new treatments for small cell lung cancer (SCLC), achieving effective treatment has not yet happened. Targeted therapy utilizing delta-like ligand 3 (DLL3), which is highly expressed in SCLC patients, holds ...
Mohammad Hossein Ataee, Seyed Ali Mirhosseini, Reza Mirnejad, Hamideh Mahmoodzadeh Hosseini, Jafar Amani   +4 more
doaj   +2 more sources

Integrated bioprocessing and genetic strategies to enhance soluble expression of anti-HER2 immunotoxin in E. Coli [PDF]

AMB Express
Immunotoxins are widely applied for cancer therapy. However, bacterial expression of immunotoxins usually leads to the formation of insoluble and non-functional recombinant proteins. This study was aimed to improve soluble expression of a novel anti-HER2
Sheida Mani, Bahareh Arab, Vajihe Akbari, C. Perry Chou   +3 more
doaj   +2 more sources

Unlocking the potential of engineered microbes in immunotoxin-based cancer therapy [PDF]

Frontiers in Microbiology
Immunotoxins (ITs), as targeted cancer therapies, confront limitations including off-target effects, immunogenicity, and inadequate tumor penetration, hindering clinical translation.
Quan Wang, Quan Wang, Rui Cao, Yuxing Xie, Zhuoyi Zhang, Xianguo Li, Yan Zhang, Haolin Luo, Hui Yao, Ping Xue, Shuai Ni   +10 more
doaj   +2 more sources

Production and Verification of Anti-Tumor Activity of Monoclonal Anti-EGFR-Recombinant PE38 Immunotoxin in A431 Tumor Cells [PDF]

ImmunoAnalysis, 2021
Background: Tumor growth and progression depend largely on the activity of cell membrane receptors like epidermal growth factor receptor (EGFR). This receptor plays a significant role in the growth and survival of many solid tumors.
Khalil Hajiasgharzadeh, Leili Aghebati Maleki, Behzad Baradaran   +2 more
doaj   +1 more source

In vivo solid tumor targeting with recombinant VEGF-diphtheria immunotoxin [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): A variety of signaling molecules have been identified that play a role in angiogenesis, of prime importance, vascular endothelial growth factor (VEGF) and its resceptor (VEGFR), which is highly expressed in most human solid tumors ...
Mohammad Hosseininejad-Chafi, Ehsan Alirahimi, Behzad Ramezani, Akbar Oghalaei, Nazli Sotoudeh, Hajarsadat Ghaderi, Fatemeh Kazemi-Lomedasht, Mahdi Habibi-Anbouhi, Reza Moazzami, Mahdi Behdani   +9 more
doaj   +1 more source

An immunotoxin targeting Ebola virus glycoprotein inhibits Ebola virus production from infected cells.

PLoS ONE, 2021
Ebola virus (EBOV), a member of the mononegaviral family Filoviridae, causes severe disease associated with high lethality in humans. Despite enormous progress in development of EBOV medical countermeasures, no anti-EBOV treatment has been approved.
Yingyun Cai, Shuiqing Yu, Xiaoli Chi, Sheli R Radoshitzky, Jens H Kuhn, Edward A Berger   +5 more
doaj   +1 more source

The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy. [PDF]

, 2011
BackgroundTumor microenvironments present significant barriers to penetration by antibodies and immunoconjugates. Tumor microenvironments, however, are difficult to study in vitro.
Broaddus, V Courtney, Feng, Mingqian, Fitzgerald, David, Hassan, Raffit, Ho, Mitchell, Nagashima, Kunio, Phung, Yen, Xiang, Xinran, Zhang, Jingli   +8 more
core   +6 more sources

Enhanced cytotoxicity of a Pseudomonas Exotoxin A based immunotoxin against prostate cancer by addition of the endosomal escape enhancer SO1861

Frontiers in Pharmacology, 2023
Immunotoxins consist of an antibody or antibody fragment that binds to a specific cell surface structure and a cytotoxic domain that kills the cell after cytosolic uptake. Pseudomonas Exotoxin A (PE) based immunotoxins directed against a variety of tumor
Anie P. Masilamani, Anie P. Masilamani, Nathalie Huber, Nathalie Huber, Constanze Nagl, Constanze Nagl, Viviane Dettmer-Monaco, Viviane Dettmer-Monaco, Viviane Dettmer-Monaco, Gianni Monaco, Gianni Monaco, Gianni Monaco, Gianni Monaco, Isis Wolf, Isis Wolf, Isis Wolf, Susanne Schultze-Seemann, Susanne Schultze-Seemann, Sanaz Taromi, Sanaz Taromi, Sanaz Taromi, Christian Gratzke, Christian Gratzke, Hendrik Fuchs, Philipp Wolf, Philipp Wolf   +25 more
doaj   +1 more source

Targeted delivery of immunotoxin by antibody to ganglioside GD3: a novel drug delivery route for tumor cells. [PDF]

PLoS ONE, 2013
Gangliosides are sialic acid-containing glycolipids expressed on plasma membranes from nearly all vertebrate cells. The expression of ganglioside GD3, which plays essential roles in normal brain development, decreases in adults but is up regulated in ...
Vanina Torres Demichelis, Aldo A Vilcaes, Ramiro Iglesias-Bartolomé, Fernando M Ruggiero, Jose L Daniotti   +4 more
doaj   +1 more source

GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer. [PDF]

, 2014
The emergence of targeted cancer therapy has been limited by the paucity of determinants which are tumor-specific and generally associated with disease, and have cell dynamics which effectively deploy cytotoxic payloads.
Berman-Booty, Lisa D, Magee, Michael Sullivan, Marszalowicz, Glen P, Merlino, Dante, Snook, Adam E, Waldman, Scott A   +5 more
core   +6 more sources