A double safety lock tumor-specific device for suicide gene therapy in breast cancer [PDF]
, 2020 Producción CientíficaThe complexity and continuous evolution of cancer make the design of novel strategies of treatment a constant challenge in biomedicine.
Arias Vallejo, Francisco Javier +5 more
core +2 more sources
Glycosylation of glycolipids in cancer: basis for development of novel therapeutic approaches [PDF]
, 2013 Altered networks of gene regulation underlie many pathologies, including cancer. There are several proteins in cancer cells that are turned either on or off, which dramatically alters the metabolism and the overall activity of the cell, with the complex ...
Daniotti, Jose Luis +4 more
core +2 more sources
Design and evaluation of a peptide‐based immunotoxin for breast cancer therapeutics
FEBS Open Bio, 2015 Immunotoxins are chimeric proteins comprising a specific cellular targeting domain linked to a cytotoxic factor. Here we describe the design and use of a novel, peptide‐based immunotoxin that can initiate selective cytotoxicity on ErbB2‐positive cells ...
Kelsey J. Weigel +6 more
doaj +1 more source
Evaluation of cholinergic markers in Alzheimer's disease and in a model of cholinergic deficit [PDF]
, 2005 Cognitive deficits in neuropsychiatric disorders, such as Alzheimer's disease (AD), have been closely related to cholinergic deficits. We have compared different markers of cholinergic function to assess the best biomarker of cognitive deficits ...
Dominguez, J. (Jon) +4 more
core +1 more source
In Vitro Evaluation of Vegf-Pseudomonas Exotoxin: A Conjugated on Tumor Cells
Advanced Biomedical Research, 2017 Background: Angiogenesis which occurs mandatory in solid tumors, is a critical step in malignancy progression. Vascular endothelial growth factor (VEGF) is mainly responsible for angiogenesis process and facilitates the formation of new vessels ...
Jahangir Langari +10 more
doaj +1 more source
Engineering of Ribosome-inactivating Proteins for Improving Pharmacological Properties
Toxins, 2020 Ribosome-inactivating proteins (RIPs) are N-glycosidases, which depurinate a specific adenine residue in the conserved α-sarcin/ricin loop (α-SRL) of rRNA.
Jia-Qi Lu +3 more
doaj +1 more source
Second line therapy in malignant pleural mesothelioma: a systematic review [PDF]
, 2015 After the implementation of standard first line chemotherapy with platinum and antifolates in pleural mesothelioma, patients are confronted with a need for second line treatment at relapse or progression.
Baas, Paul +3 more
core +2 more sources
Systemic effects of tissue plasminogen activator-associated fibrinolysis and its relation to thrombin generation in orthotopic liver transplantation [PDF]
, 1989 Orthotopic liver transplantation is frequently associated with hyperfibrinolysis, the origin and clinical relevance of which is largely unknown. In 20 orthotopic liver transplantations, we studied the occurrence and systemic effects of hyperfibrinolysis.
Bontempo, FA +5 more
core +1 more source
Biotherapy, 1991 Immunotoxins (ITs) are chimeric molecules constructed by covalently conjugating monoclonal antibodies (MoAbs) to plant or bacterial toxins (e.g. ricin or pseudomonas exotoxin). The antibody moiety allows specific targeting of ITs to tumor-associated antigens, while the toxin moiety is responsible for cell killing by irreversible inactivation of protein
openaire +4 more sources
Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4+ Treg in nonhuman primates
Molecular Oncology, 2018 Recently, we have developed a diphtheria toxin‐based recombinant anti‐human CCR4 immunotoxin for targeting CCR4+ tumors and Tregs. In this study, we further optimized the dosing schedule for improved CCR4+ Treg depletion.
Zhaohui Wang +10 more
doaj +1 more source