Results 51 to 60 of about 4,550 (156)

The CNS Meninges and the Synovial Joint: Parallel Immunological Structures in Autoimmune Disease

BioEssays, Volume 48, Issue 2, February 2026.
The meninges and synovium share multiple functional and structural characteristics and act as specialized immunological barriers. In MS and RA, both can host tertiary lymphoid organs (TLOs) and CD4+ Tph cells. We highlight how these features sustain compartmentalized inflammation and explore a possible role for EBV in their formation and persistence ...
Mohamed Reda Fazazi, Manu Rangachari
wiley   +1 more source

Targeted Apoptosis Activation with GrB/scFvMEL Modulates Melanoma Growth, Metastatic Spread, Chemosensitivity, and Radiosensitivity

Neoplasia: An International Journal for Oncology Research, 2006
GrB/scFvMEL, a fusion protein composed of human granzyme B (GrB) and the single-chain antibody scFvMEL, targets melanoma gp240 antigen and exerts impressive cytotoxic effects by inducing apoptosis. We evaluated the effects of GrB/scFvMEL on chemotherapy,
Yuying Liu, Weihe Zhang, Ting Niu, Lawrence H. Cheung, Anupama Munshi, Raymond E. Meyn, Jr., Michael G. Rosenblum   +6 more
doaj   +1 more source

Ablation of Unilateral Hippocampal GABAergic Neurons: A Novel Mouse Model of Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
A novel mouse model of mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (HS) by unilateral, partial ablation of hippocampal GABAergic neurons is established. The model recapitulates key features of the human condition, including spontaneous recurrent seizures, HS‐like pathology, and associated cognitive deficits.
Ting Tang, Jinkun Xu, Bin Fu, Chao Geng, Yuhao Li, Yuying Qi, Changkai Hou, Junping He, Yihe Wang, Yumin Luo, Guoguang Zhao   +10 more
wiley   +1 more source

A Novel Immunotoxin Based on BmK AGAP Toxin for HER2-Positive Breast Cancer: An In Silico Study [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: Breast cancer remains one of the leading causes of cancer-related deaths among women worldwide. The HER2 protein, an epidermal growth factor receptor, is overexpressed in approximately 25% of breast cancer cases, making it a key ...
Sadaf Azdoo, Samira Mokhtari, Navid Nezafat, Farzaneh Vahedi, Mortaza Taheri-Anganeh, Khadijeh Ahmadi, Mehdi Alizadeh, Seyyed Hossein Khatami, Mohamad Sabaghan, Rahmatollah Soltani, Vahid Zarezade, Ahmad Movahedpour, Hassan Ghasemi   +12 more
doaj  

Cloning and Expression of Recombinant Immunotoxin using Diphtheria Toxin and Granulocyte Colony Stimulating Factor (G-CSF) [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2016
Background: Immunotoxin (IT) is a directed toxin containing two distinct sections (immune and toxin parts) covalently bond using specific chemical or peptide linkers.
Fatemeh Donyapoor, Mehdi Zeinoddini, Ali Reza Saeedinia   +2 more
doaj  

Interactions Between Pseudomonas Immunotoxins and the Plasma Membrane: Implications for CAT-8015 Immunotoxin Therapy

Frontiers in Oncology, 2018
Acute Lymphoblastic Leukemia (ALL) remains the most frequent cause of cancer-related mortality in children and novel therapies are needed for the treatment of relapsed/refractory childhood ALL.
Monika Bokori-Brown, Jeremy Metz, Peter G. Petrov, Francis Mussai, Carmela De Santo, Neil J. Smart, Sarah Saunders, Bridget Knight, Ira Pastan, Richard W. Titball, C. Peter Winlove   +10 more
doaj   +1 more source

Exploring the Role of Acrylamide in Food Allergy via Dendritic Cell‐Dependent Th2 Immune Responses

Food Frontiers, Volume 7, Issue 1, January 2026.
Acrylamide may disrupt immune tolerance as a foodborne immunotoxicant, priming allergic inflammatory susceptibility through DC‐dependent Th2/Th17 polarization, TLR4/NF‐κB signaling amplification, and IL‐10 production suppression. ABSTRACT Acrylamide (AA), a prevalent food processing contaminant with recognized multi‐organ toxicity, has an unexplored ...
Xue Feng, Jiamin Chen, Zhencong Yang, Philippe Madjirebaye, Zhoujin Xu, Li Yan, Yuting Fan, Xiaoliang Shu, Xuli Wu   +8 more
wiley   +1 more source

Immunotoxins Targeting B cell Malignancy—Progress and Problems With Immunogenicity

Biomedicines, 2018
Few immunotoxins or targeted toxins have become mainline cancer therapies. Still immunotoxins continue to be of major interest and subject of research and development as alternative therapies for drug resistant cancer. A major matter of concern continues
Daniel A. Vallera, Robert J. Kreitman
doaj   +1 more source

Comprehensive Review on the Occurrence of Aflatoxin M1 in Milk, Prevalent Health Issues Associated With It, and Innovative Strategies for Mitigation of Aflatoxin M1 in Processed Milk

Food Safety and Health, Volume 4, Issue 1, Page 67-81, January 2026.
Aflatoxins, carcinogenic compounds in milk; reduction strategies such as thermal deactivation, UV light exposure, ionizing radiation, and solvent extraction. ABSTRACT Aflatoxins (AFs) are known to be cancer causing substances recognized within milk along with the milk goods.
Akshay Ramani, Tanmay Hazra, Anamika Das, Subhadip Manik, Ayon Tarafdar, Swarnima Dey, Umesh Singh   +6 more
wiley   +1 more source

Design of a Humanized Immunotoxin Based on Pertuzumab-Derived scFv and Shiga-Like Toxin 2 Subunit A Against Breast Cancer: An In Silico Study [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: Breast cancer is the second cause of mortality among women. HER2, a member of the epidermal growth factor receptor family, is overexpressed in approximately 25% of breast cancer cases.
Zeinab Ghesmati, Khadijeh Ahmadi, Navid Nezafat, Farzaneh Vahedi, Mortaza Taheri-Anganeh, Seyyed Hossein Khatami, Hasan Ghasemi, Rahmatollah Soltani, Vahid Zarezade, Ahmad Movahedpour, Ahmad Movahedpour   +10 more
doaj