Results 61 to 70 of about 10,277 (200)

Exploring the Role of Acrylamide in Food Allergy via Dendritic Cell‐Dependent Th2 Immune Responses

Food Frontiers, Volume 7, Issue 1, January 2026.
Acrylamide may disrupt immune tolerance as a foodborne immunotoxicant, priming allergic inflammatory susceptibility through DC‐dependent Th2/Th17 polarization, TLR4/NF‐κB signaling amplification, and IL‐10 production suppression. ABSTRACT Acrylamide (AA), a prevalent food processing contaminant with recognized multi‐organ toxicity, has an unexplored ...
Xue Feng, Jiamin Chen, Zhencong Yang, Philippe Madjirebaye, Zhoujin Xu, Li Yan, Yuting Fan, Xiaoliang Shu, Xuli Wu   +8 more
wiley   +1 more source

Comprehensive Review on the Occurrence of Aflatoxin M1 in Milk, Prevalent Health Issues Associated With It, and Innovative Strategies for Mitigation of Aflatoxin M1 in Processed Milk

Food Safety and Health, Volume 4, Issue 1, Page 67-81, January 2026.
Aflatoxins, carcinogenic compounds in milk; reduction strategies such as thermal deactivation, UV light exposure, ionizing radiation, and solvent extraction. ABSTRACT Aflatoxins (AFs) are known to be cancer causing substances recognized within milk along with the milk goods.
Akshay Ramani, Tanmay Hazra, Anamika Das, Subhadip Manik, Ayon Tarafdar, Swarnima Dey, Umesh Singh   +6 more
wiley   +1 more source

Targeted Apoptosis Activation with GrB/scFvMEL Modulates Melanoma Growth, Metastatic Spread, Chemosensitivity, and Radiosensitivity

Neoplasia: An International Journal for Oncology Research, 2006
GrB/scFvMEL, a fusion protein composed of human granzyme B (GrB) and the single-chain antibody scFvMEL, targets melanoma gp240 antigen and exerts impressive cytotoxic effects by inducing apoptosis. We evaluated the effects of GrB/scFvMEL on chemotherapy,
Yuying Liu, Weihe Zhang, Ting Niu, Lawrence H. Cheung, Anupama Munshi, Raymond E. Meyn, Jr., Michael G. Rosenblum   +6 more
doaj   +1 more source

Cloning and Expression of Recombinant Immunotoxin using Diphtheria Toxin and Granulocyte Colony Stimulating Factor (G-CSF) [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2016
Background: Immunotoxin (IT) is a directed toxin containing two distinct sections (immune and toxin parts) covalently bond using specific chemical or peptide linkers.
Fatemeh Donyapoor, Mehdi Zeinoddini, Ali Reza Saeedinia   +2 more
doaj  

Selective inhibition of dopamine-beta-hydroxylase enhances dopamine release from noradrenergic terminals in the medial prefrontal cortex [PDF]

, 2015
Introduction: Disulfiram has been claimed to be useful in cocaine addiction therapy, its efficacy being attributed to dopamine-beta-hydroxylase (DBH) inhibition.
Devoto, Paola, Flore, Giovanna, Frau, Roberto, Gessa, Gian L., Saba, Pierluigi   +4 more
core   +1 more source

Bifenthrin Under Scrutiny: Revisiting Toxicological Evidence Amid Regulatory Gaps

Journal of Applied Toxicology, Volume 46, Issue 1, Page 61-77, January 2026.
ABSTRACT Despite growing health concerns, bifenthrin (BF) remains widely used for controlling agricultural and residential pests. However, different perspectives on its toxicological profile and regulatory framework warrant a revisit and update on BF regulation towards a robust risk‐safety assessment.
Caroline V. L. Moreira, John Ogbu I, Kadja L. C. Monteiro, Thiago M. de Aquino, Edeildo F. da Silva‐Júnior, Alberto S. S. Filho, Hamilton B. Napolitano, Christianah A. Elusiyan, Renê O. do Couto, Elson A. Costa, James O. Fajemiroye   +10 more
wiley   +1 more source

A Novel Immunotoxin Based on BmK AGAP Toxin for HER2-Positive Breast Cancer: An In Silico Study [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: Breast cancer remains one of the leading causes of cancer-related deaths among women worldwide. The HER2 protein, an epidermal growth factor receptor, is overexpressed in approximately 25% of breast cancer cases, making it a key ...
Sadaf Azdoo, Samira Mokhtari, Navid Nezafat, Farzaneh Vahedi, Mortaza Taheri-Anganeh, Khadijeh Ahmadi, Mehdi Alizadeh, Seyyed Hossein Khatami, Mohamad Sabaghan, Rahmatollah Soltani, Vahid Zarezade, Ahmad Movahedpour, Hassan Ghasemi   +12 more
doaj  

Interactions Between Pseudomonas Immunotoxins and the Plasma Membrane: Implications for CAT-8015 Immunotoxin Therapy

Frontiers in Oncology, 2018
Acute Lymphoblastic Leukemia (ALL) remains the most frequent cause of cancer-related mortality in children and novel therapies are needed for the treatment of relapsed/refractory childhood ALL.
Monika Bokori-Brown, Jeremy Metz, Peter G. Petrov, Francis Mussai, Carmela De Santo, Neil J. Smart, Sarah Saunders, Bridget Knight, Ira Pastan, Richard W. Titball, C. Peter Winlove   +10 more
doaj   +1 more source

Secondary Necrosis Following Caspase‐Activation can Occur Independently of Gasdermin E

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Secondary necrosis follows apoptosis, but its mechanism is unclear. This study shows that although gasdermin E is cleaved during this process, it is not required for membrane rupture. Across multiple models, secondary necrosis occurred regardless of gasdermin E presence, challenging prior claims and redefining the understanding of how apoptotic cells ...
Shubhangi Gavali, Francesca Maremonti, Wulf Tonnus, Florian Gembardt, Marlena Nastassja Schlecht, Karolin Flade, Anne von Mässenhausen, Stephen W. G. Tait, Stefan R. Bornstein, Andreas Linkermann   +9 more
wiley   +1 more source

Immunotoxins Targeting B cell Malignancy—Progress and Problems With Immunogenicity

Biomedicines, 2018
Few immunotoxins or targeted toxins have become mainline cancer therapies. Still immunotoxins continue to be of major interest and subject of research and development as alternative therapies for drug resistant cancer. A major matter of concern continues
Daniel A. Vallera, Robert J. Kreitman
doaj   +1 more source