Results 61 to 70 of about 4,550 (156)
Toxins, 2017 Cancer immunotherapy is becoming a routine treatment modality in the oncology clinic, in spite of the fact that it is a relatively nascent field. The challenge in developing effective immunotherapeutics is the identification of target molecules that ...
Trevor R. Baybutt +2 more
doaj +1 more source
Bifenthrin Under Scrutiny: Revisiting Toxicological Evidence Amid Regulatory Gaps
Journal of Applied Toxicology, Volume 46, Issue 1, Page 61-77, January 2026.ABSTRACT Despite growing health concerns, bifenthrin (BF) remains widely used for controlling agricultural and residential pests. However, different perspectives on its toxicological profile and regulatory framework warrant a revisit and update on BF regulation towards a robust risk‐safety assessment.
Caroline V. L. Moreira +10 more
wiley +1 more source
Treatment with immunotoxin [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001 T–cell depletion prior to or beginning at the time of transplantation has been shown to be a valuable adjunct to the induction of immunological unresponsiveness. Both total lymphoid irradiation and anti–lymphocyte globulin have been used for this purpose in experimental models of transplantation as well as in human organ transplant recipients. However,
openaire +2 more sources
Secondary Necrosis Following Caspase‐Activation can Occur Independently of Gasdermin E
Advanced Science, Volume 12, Issue 46, December 11, 2025.Secondary necrosis follows apoptosis, but its mechanism is unclear. This study shows that although gasdermin E is cleaved during this process, it is not required for membrane rupture. Across multiple models, secondary necrosis occurred regardless of gasdermin E presence, challenging prior claims and redefining the understanding of how apoptotic cells ...
Shubhangi Gavali +9 more
wiley +1 more source
Immunotoxins: Targeted Toxin Delivery for Cancer Therapy
Pharmaceutical Fronts, 2019 Immunotoxins are proteins that consist of a protein toxin conjugated to a specific targeting moiety. The targeting moiety is usually an antibody or ligand, such as monoclonal antibody, antibody fragment, a cytokine, or a growth factor. The toxins usually
Xin Mei +3 more
doaj +1 more source
The Immune Microenvironment in Liver Cancer: From Analysis to Targeting
Advanced Science, Volume 12, Issue 47, December 18, 2025.This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan +5 more
wiley +1 more source
Toxins, 2020 Toxins, while harmful and potentially lethal, have been engineered to develop potent therapeutics including cytotoxins and immunotoxins (ITs), which are modalities with highly selective targeting capabilities.
Shusei Hamamichi +2 more
doaj +1 more source
MedComm – Oncology, Volume 4, Issue 4, December 2025.Parkinson's disease (PD) and glioma are neurological disorders with distinct and even opposing mechanisms: α‐synuclein deposition and neuronal loss in PD versus glial cell malignancy in glioma. Despite these differences, their contrasting pathologies highlight multiple therapeutic targets.
Tianli Pan +7 more
wiley +1 more source
Journal of Biomechanical Science and Engineering, 2011 The purpose of this research is to develop minimally invasive medical devices by applying heated actuations of Shape Memory Alloy (SMA) transducers using a medical Ti-Ni alloy in order to enable minimal hypodermic invasive microvolume for either blood ...
Hidetake YAMAMOTO
doaj +1 more source
Targeting Receptors on Cancer Cells with Protein Toxins
Biomolecules, 2020 Cancer cells frequently upregulate surface receptors that promote growth and survival. These receptors constitute valid targets for intervention. One strategy involves the delivery of toxic payloads with the goal of killing those cancer cells with high ...
Antonella Antignani +5 more
doaj +1 more source