Results 71 to 80 of about 10,277 (200)

Immuno-targeting the multifunctional CD38 using nanobody [PDF]

, 2016
published_or_final_versio
Deng, QW, Hao, Q, Hou, YN, Koch-Nolte, F, Lam, MC, Lee, HC, Li, T, Liu, J, Qi, S, Unger, M, Wang, XW, Xin, D, Zhang, H, Zhang, P, Zhao, YJ   +14 more
core   +1 more source

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan, Hao Li, Jian Xue, Yourong Duan, Jin Sun, Meng Niu   +5 more
wiley   +1 more source

Botulinum neurotoxin type C protease induces apoptosis in differentiated human neuroblastoma cells [PDF]

, 2016
Neuroblastomas constitute a major cause of cancer-related deaths in young children. In recent years, a number of translation-inhibiting enzymes have been evaluated for killing neuroblastoma cells. Here we investigated the potential vulnerability of human
Binz, T., Davletov, B., Leese, C., Rust, A.   +3 more
core   +1 more source

Parkinson's Disease and Cancer: Mechanistic Insights and Therapeutic Opportunities From Cancer Neuroscience

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Parkinson's disease (PD) and glioma are neurological disorders with distinct and even opposing mechanisms: α‐synuclein deposition and neuronal loss in PD versus glial cell malignancy in glioma. Despite these differences, their contrasting pathologies highlight multiple therapeutic targets.
Tianli Pan, Lin Yuan, Ruoyang Zhao, Liting Lu, Yinghao Zhi, Yuying Li, Min Wu, Yongye Huang   +7 more
wiley   +1 more source

Design of a Humanized Immunotoxin Based on Pertuzumab-Derived scFv and Shiga-Like Toxin 2 Subunit A Against Breast Cancer: An In Silico Study [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: Breast cancer is the second cause of mortality among women. HER2, a member of the epidermal growth factor receptor family, is overexpressed in approximately 25% of breast cancer cases.
Zeinab Ghesmati, Khadijeh Ahmadi, Navid Nezafat, Farzaneh Vahedi, Mortaza Taheri-Anganeh, Seyyed Hossein Khatami, Hasan Ghasemi, Rahmatollah Soltani, Vahid Zarezade, Ahmad Movahedpour, Ahmad Movahedpour   +10 more
doaj  

The Heat-Stable Enterotoxin Receptor, Guanylyl Cyclase C, as a Pharmacological Target in Colorectal Cancer Immunotherapy: A Bench-to-Bedside Current Report

Toxins, 2017
Cancer immunotherapy is becoming a routine treatment modality in the oncology clinic, in spite of the fact that it is a relatively nascent field. The challenge in developing effective immunotherapeutics is the identification of target molecules that ...
Trevor R. Baybutt, Allison A. Aka, Adam E. Snook   +2 more
doaj   +1 more source

Stimuli‐responsive systems: A focus on controlled drug delivery for posterior segment ocular disease

Responsive Materials, Volume 3, Issue 4, November 2025.
This review highlights recent advances in stimuli‐responsive drug delivery for posterior segment diseases, focusing on mechanisms and potential. It also explores mechanically interlocked molecules and bioorthogonal reactions as novel approaches. Challenges and future perspectives are discussed, aiming to bridge the gap between research and clinical ...
Chengzhi Zhang, Jiayi Hou, Yameng Zhao, Yiwen Wang, Kexin Wang, Siyu Li, Yange Wang, Jiehao Zhang, Shenao Ding, Chenxu Zhang, Zongming Song, Ye Tao   +11 more
wiley   +1 more source

Treatment with immunotoxin [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001
T–cell depletion prior to or beginning at the time of transplantation has been shown to be a valuable adjunct to the induction of immunological unresponsiveness. Both total lymphoid irradiation and anti–lymphocyte globulin have been used for this purpose in experimental models of transplantation as well as in human organ transplant recipients. However,
openaire   +2 more sources

Real‐Time In Vivo Monitoring of Cholinergic Neurotransmission in the Mouse Brain Using a Microelectrochemical Choline Biosensor

European Journal of Neuroscience, Volume 62, Issue 9, November 2025.
The measurement of choline as a biomarker for in vivo cholinergic neurotransmission is a valuable tool in the study of a range of CNS disorders. However, the continuous detection of cholinergic neurotransmission in selective brain regions in the mouse brain remains challenging and underexploited.
Seán Doyle, Michelle M. Doran, Colm Cunningham, John Patrick Lowry   +3 more
wiley   +1 more source

Immunotoxins: Targeted Toxin Delivery for Cancer Therapy

Pharmaceutical Fronts, 2019
Immunotoxins are proteins that consist of a protein toxin conjugated to a specific targeting moiety. The targeting moiety is usually an antibody or ligand, such as monoclonal antibody, antibody fragment, a cytokine, or a growth factor. The toxins usually
Xin Mei, Junsheng Chen, Jing Wang, Jianwei Zhu   +3 more
doaj   +1 more source