Results 81 to 90 of about 10,277 (200)
Cancer Reports, Volume 8, Issue 10, October 2025.ABSTRACT Background Hairy cell leukemia (HCL) is a rare disorder characterized by splenomegaly, pancytopenia, and proliferation with “hairy” lymphocytes. Treatment is based on purine analogs and anti‐CD20 antibodies, often resulting in significant adverse effects.
M. Garcia Fasanella +4 more
wiley +1 more source
Toxins, 2020 Toxins, while harmful and potentially lethal, have been engineered to develop potent therapeutics including cytotoxins and immunotoxins (ITs), which are modalities with highly selective targeting capabilities.
Shusei Hamamichi +2 more
doaj +1 more source
Peritoneal Immunosurgery: Immunotherapy Augmented Surgery for the Treatment of Peritoneal Cancers
Journal of Surgical Oncology, Volume 132, Issue 5, Page 789-809, October 2025.ABSTRACT Peritoneal malignancy often indicates disruptions in multiple physiological systems resulting from widespread cancer. The heterogenous origin and dynamic nature of peritoneal cancer make it difficult to treat with standard approaches that fit into guidelines.
Ada I. Ozcan +4 more
wiley +1 more source
Journal of Biomechanical Science and Engineering, 2011 The purpose of this research is to develop minimally invasive medical devices by applying heated actuations of Shape Memory Alloy (SMA) transducers using a medical Ti-Ni alloy in order to enable minimal hypodermic invasive microvolume for either blood ...
Hidetake YAMAMOTO
doaj +1 more source
Targeting Receptors on Cancer Cells with Protein Toxins
Biomolecules, 2020 Cancer cells frequently upregulate surface receptors that promote growth and survival. These receptors constitute valid targets for intervention. One strategy involves the delivery of toxic payloads with the goal of killing those cancer cells with high ...
Antonella Antignani +5 more
doaj +1 more source
Eye-specific retinogeniculate segregation proceeds normally following disruption of patterned spontaneous retinal activity [PDF]
, 2014 Background: Spontaneous retinal activity (SRA) is important during eye-specific segregation within the dorsal lateral geniculate nucleus (dLGN), but the feature(s) of activity critical for retinogeniculate refinement are controversial.
Chapman, Barbara +5 more
core +3 more sources
EGFR: New Insights on Its Activation and Mutation in Tumor and Tumor Immunotherapy
Advanced Science, Volume 12, Issue 36, September 25, 2025.This review provides new perspectives on EGFR's activation, mutations, and their impact on tumor immunotherapy. It summarizes how EGFR is activated and the current EGFR targeting strategy, evaluates their clinical outcomes in combination with immunotherapy, highlighting differential responses in tumors with EGFR wild‐type and different mutants.
Yuanzhuo Gu +7 more
wiley +1 more source
Toxins, 2017 Immunotoxins (ITs) are hybrid proteins combining the binding specificity of antibodies with the cytocidal properties of toxins. They represent a promising approach to lymphoma therapy. The cytotoxicity of two immunotoxins obtained by chemical conjugation
Letizia Polito +6 more
doaj +1 more source
Pleural Mesothelioma: Pathogenesis, Diagnosis, Treatment, Prognosis, and Survival
MedComm, Volume 6, Issue 9, September 2025.This is an overview of current and emerging therapeutic strategies for pleural mesothelioma (PM), including chemotherapy, immunotherapy (ICIs, dendritic cell vaccines, CAR‐T therapy), anti‐angiogenic therapy, epigenetic modifications (DNA methylation, histone changes, non‐coding RNAs), and targeted therapy focusing on genomic alterations and signaling ...
Libo Zhang, Meijuan Huang
wiley +1 more source
Bacterial Toxins for Cancer Therapy
Toxins, 2017 Several pathogenic bacteria secrete toxins to inhibit the immune system of the infected organism. Frequently, they catalyze a covalent modification of specific proteins. Thereby, they block production and/or secretion of antibodies or cytokines. Moreover,
Nour-Imene Zahaf, Gudula Schmidt
doaj +1 more source