Results 121 to 130 of about 29,648 (219)

Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity

eLife, 2015
Nuclear pore complexes (NPCs) conduct massive transport mediated by shuttling nuclear transport receptors (NTRs), while keeping nuclear and cytoplasmic contents separated.
Hermann Broder Schmidt, Dirk Görlich
doaj   +1 more source

Importin subunit beta‐1 mediates ERK5 nuclear translocation, and its inhibition synergizes with ERK5 kinase inhibitors in reducing cancer cell proliferation

Molecular Oncology
The mitogen‐activated protein kinase (MAPK) extracellular signal‐regulated kinase 5 (ERK5) is emerging as a promising target in cancer. Indeed, alterations of the MEK5/ERK5 pathway are present in many types of cancer, including melanoma.
Zoe Lombardi, Lucia Gardini, Anatolii V. Kashchuk, Alessio Menconi, Matteo Lulli, Ignazia Tusa, Alessandro Tubita, Luisa Maresca, Barbara Stecca, Marco Capitanio, Elisabetta Rovida   +10 more
doaj   +1 more source

Importin Beta [PDF]

Molecular Cell, 2004
Harel, Amnon, Forbes, Douglass J.
openaire   +1 more source

Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses

Nature Communications, 2018
Importin α isoforms regulate the nuclear import of different cargo proteins but the mechanisms conferring isoform specificity are not fully understood. Here, the authors study the interactions of importin α1 and α3 with two viral cargos, elucidating the ...
Kate M. Smith, Sofiya Tsimbalyuk, Megan R. Edwards, Emily M. Cross, Jyoti Batra, Tatiana P. Soares da Costa, David Aragão, Christopher F. Basler, Jade K. Forwood   +8 more
doaj   +1 more source

The first passage problem for diffusion through a cylindrical pore with sticky walls

, 2009
We calculate the first passage time distribution for diffusion through a cylindrical pore with sticky walls. A particle diffusively explores the interior of the pore through a series of binding and unbinding events with the cylinder wall.
Grill, Stephan W., Licata, Nicholas A.
core   +1 more source

Design of an in vitro assay to optimize assembly of nanoparticle-tagged nuclear import complexes [PDF]

, 2007
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007.Includes bibliographical references (leaf 20).Maintaining protein function at the biological-inorganic interface is a critical challenge for bionanotechnology ...
Rosenbaum, Lara Elise
core  

Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A

The EMBO Journal
Sphingosine and constrained analogs like FTY720 and SH-BC-893 restrain tumor growth through incompletely defined mechanisms that include protein phosphatase 2A (PP2A) activation.
Vaishali Jayashankar, Peter Kubiniok, Alison N McCracken, Rebeca G Gentry, Kazumi H Eckenstein, Lorenzo Sernissi, Vito Vece, Jean-Baptiste Garsi, Sarah Y Valles, Sunhee Jung, Natalie C Hoffman, Arielle S Perrochon, Elizabeth M Selwan, Brendan T Finicle, Mary Pitman, DaWei Lin, Éric Bonneil, Ruijuan Xu, Cungui Mao, Peter Kaiser, David A Fruman, David Mobley, Cholsoon Jang, Stephen Hanessian, Pierre Thibault, Aimee L Edinger   +25 more
doaj   +1 more source

PCV2 Cap protein nuclear import via importin α/β receptor: molecular insights and antiviral potential. [PDF]

Front Microbiol
Lin C, Li N, Tao L, Li H, Ma J, Wu C, Zhang F, Fang S, Tan J, Huang Y, Zeng X, Zeng Y.   +11 more
europepmc   +1 more source

Can <i>Fusobacterium</i> utilize nucleomodulins in the pathophysiology of CRC? [PDF]

Front Cell Infect Microbiol
Anand S, Korgaonkar S, Bose C.
europepmc   +1 more source

Towards a universal cross-linking mass spectrometry approach for protein structure analysis with homo-bi-functional photo-activatable cross-linkers. [PDF]

Commun Biol
Ser Z, Ong AGM, Wang SM, Sobota RM.
europepmc   +1 more source