Results 71 to 80 of about 29,648 (219)

Plasmodesmata‐located proteins: The molecular hubs in noncell‐autonomous immunity

New Plant Protection, EarlyView.
Plasmodesmata serve as critical battlefields for plant immunity, regulated by diverse proteins. This article provides a comprehensive review of the regulatory mechanisms, challenges, and future directions concerning proteins located within plasmodesmata and their roles in plant defense responses.
Zheng Wu, Xiaoyi Shan
wiley   +1 more source

The F-actin filament capping protein CapG is a bona fide nucleolar protein [PDF]

, 2008
Actin works in concert with myosin I to regulate the transcription of ribosomal genes in the nucleolus. Recently, nucleolar actin has been shown to be active in its polymeric form raising the question how actin dynamics is regulated in the nucleolus ...
Gettemans, Jan, Hubert, Thomas, Van Impe, Katrien, Vandekerckhove, Joël   +3 more
core   +2 more sources

Enforced Unfolding and Mechanical Properties of the Importin-Beta and Importin-Beta-Binding-Domain Complex [PDF]

Biophysical Journal, 2013
Importin-beta plays an important role in material exchange between the cell nucleus and the cytoplasm. In order to transport large molecules through the nuclear pore complex it has to bind tightly to the importin-beta-binding (IBB) domain of its cargo.To probe the mechanical properties of this binding, enforced unbinding was investigated by single ...
Russek, A., Grubmüller, H.
openaire   +3 more sources

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Importin α3 (KPNA3) Deficiency Augments Effortful Reward-Seeking Behavior in Mice

Frontiers in Neuroscience, 2022
Importin α3 (Gene: Kpna3, the ortholog of human Importin α4) is a member of the importin α family and participates in nucleocytoplasmic transport by forming trimeric complexes between cargo proteins and importin β1.
Yoshiatsu Aomine, Yoshiatsu Aomine, Koki Sakurai, Koki Sakurai, Tom Macpherson, Tom Macpherson, Takaaki Ozawa, Takaaki Ozawa, Yoichi Miyamoto, Yoshihiro Yoneda, Masahiro Oka, Takatoshi Hikida, Takatoshi Hikida   +12 more
doaj   +1 more source

The importin β/importin 7 heterodimer is a functional nuclear import receptor for histone H1 [PDF]

The EMBO Journal, 1999
Import of proteins into the nucleus proceeds through nuclear pore complexes and is largely mediated by nuclear transport receptors of the importin beta family that use direct RanGTP-binding to regulate the interaction with their cargoes. We investigated nuclear import of the linker histone H1 and found that two receptors, importin beta (Impbeta) and ...
Jäkel, S., Albig, W., Kutay, U., Bischoff, F., Schwamborn, K., Doenecke, D., Görlich, D.   +6 more
openaire   +3 more sources

Cas9 beyond CRISPR – SUMOylation, effector‐like potential and pathogenic adaptation

The FEBS Journal, EarlyView.
This Viewpoint explores the possibility that Cas9, beyond its canonical role in CRISPR immunity, may act as a host‐modulating effector during infection by Cas9‐encoding bacteria. Such a nucleomodulin‐like function could be influenced by eukaryotic post‐translational modifications, particularly SUMOylation, with potential implications for host–pathogen ...
Umut Sahin
wiley   +1 more source

A sejtmagi fehérje-import Importin-alfa2 faktorának citoplazmatikus funkciói = Cytoplasmic functions of Importin-alpha2, a factor of nuclear protein import [PDF]

, 2011
Az importin-alfa2D14 + / + importin-ßKetelRE34 Drosophila nőstényektől származó embriók letálisak. Jellemeztük a maternális interakciót. Főbb eredményeink: - embrió letalitás a szinciciális blasztoderma állapotban a metafázisban blokkolt osztódási orsó
Kiss, István, Szlanka, Tamás
core  

Higher nucleoporin-Importinβ affinity at the nuclear basket increases nucleocytoplasmic import. [PDF]

, 2013
Several in vitro studies have shown the presence of an affinity gradient in nuclear pore complex proteins for the import receptor Importinβ, at least partially contributing to nucleocytoplasmic transport, while others have historically argued against the
Azimi, Mohammad, Mofrad, Mohammad
core   +2 more sources

C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import

eLife, 2020
Disruption of nucleocytoplasmic transport is increasingly implicated in the pathogenesis of neurodegenerative diseases, including ALS caused by a C9orf72 hexanucleotide repeat expansion. However, the mechanism(s) remain unclear.
Lindsey R Hayes, Lauren Duan, Kelly Bowen, Petr Kalab, Jeffrey D Rothstein   +4 more
doaj   +1 more source