Results 91 to 100 of about 114,834,543 (300)

Development of Potentially Probiotic Mead from Co-Fermentation by Saccharomyces cerevisiae var. boulardii and Kombucha Microorganisms

Fermentation
Mead is a fermented alcoholic beverage produced from a diluted solution of honey and yeast activity. The objectives of this study were to produce a potentially probiotic mead through mixed fermentation by Saccharomyces cerevisiae var.
Handray Fernandes de Souza, Eduardo Novais Souza Freire, Giovana Felício Monteiro, Lorena Teixeira Bogáz, Ricardo Donizete Teixeira, Fabiano Vaquero Silva Junior, Felipe Donizete Teixeira, João Vitor dos Santos, Marina Vieira de Carvalho, Ramon da Silva Rocha, Adriano Gomes da Cruz, Juliana Maria Leite Nobrega de Moura Bell, Igor Viana Brandi, Eliana Setsuko Kamimura   +13 more
doaj   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Impact of the in vitro gastrointestinal digestion protocol on casein phosphopeptide profile of Grana Padano cheese digestates

LWT, 2017
Abstract The release of casein phosphopeptides (CPPs) during in vitro gastrointestinal digestion (GID) of Grana Padano (GP) cheese samples aged 13, 19 and 26 months was studied applying two protocols. The first one (PePan) was chosen as a common simple in vitro GID method, which uses only pepsin and pancreatin as digestive enzymes.
S. Cattaneo, M. Stuknytė, A. Ferraretto, I. De Noni   +3 more
openaire   +1 more source

Bovine colostrum is a health food supplement which prevents NSAID induced gut damage [PDF]

, 1999
BACKGROUNDNon-steroidal anti-inflammatory drugs (NSAIDs) are effective for arthritis but cause gastrointestinal injury. Bovine colostrum is a rich source of growth factors and is marketed as a health food supplement.AIMSTo examine whether spray dried ...
R A Goodlad, Marchbank, T, Johnson, W, D N Floyd, D P Calnan, Floyd, DN, Playford, RJ, T Marchbank, Goodlad, RA, W Johnson, Calnan, DP, R J Playford, R O Adenekan, C E Macdonald, Adenekan, RO, Macdonald, CE   +15 more
core   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Influence of storage and in vitro gastrointestinal digestion on totqal antioxidant capacity of fruit beverages

, 2011
Eight fruit beverages containing grape, orange and apricot, with/without iron and/or zinc and with/without milk added were analyzed for total antioxidant capacity (ORAC and TEAC methods), ascorbic acid content, and total polyphenols.
Reyes Barberá, Lagarda, María Jesús, Antonio Cilla, Perales, Sara, Gonzalo Clemente, Clemente Marín, Gonzalo, Cilla, Antonio, María Jesús Lagarda, Sara Perales, Barberá, Reyes, Rosaura Farré, Farré, Rosaura   +11 more
core   +1 more source

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Advanced Science, EarlyView.
After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan   +9 more
wiley   +1 more source

In vitro simulated digestion on the biostability of Hibiscus cannabinus L. seed extract

Czech Journal of Food Sciences, 2014
We investigate the biostability of phenolic acids from a kenaf (Hibiscus cannabinus L.) seed extract using an in vitro model simulating the physicochemical (pH, temperature and bile salts) and biological (gastric and pancreatic enzymes) gastrointestinal ...
Yu-Hua Wong, Chin-Ping Tan, Kamariah Long, Kar-Lin Nyam   +3 more
doaj   +1 more source

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source