Results 81 to 90 of about 114,834,543 (300)

In vitro gastrointestinal digestion increases the translocation of polystryrene nanoparticles in an in vitro intestinal co-culture model

, 2015
The conditions of the gastrointestinal tract may change the physicochemical properties of nanoparticles (NPs) and therewith the bioavailability of orally taken NPs.
van der Zande, M., Helsdingen, J.R., Hendriksen, P.J.M., Rietjens, I.M.C.M., Walczak, A.P., Kramer, E.H.M., Zande, M., van der, Bouwmeester, H.   +7 more
core   +1 more source

Simulated Gastrointestinal Digestion

, 2020
The behavior of malondialdehyde and its whey protein adducts in aqueous buffer and fully hydrogenated coconut oil-in-water emulsions stabilized by Tween 20 or by whey protein was studied during in vitro gastrointestinal digestion.
Angelique Vandemoortele, De Meulenaer, Bruno, Vandemoortele, Angelique, Babat, Pinar, Mariam Yakubu, Yakubu, Mariam, Bruno De Meulenaer, Pinar Babat   +7 more
core   +1 more source

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Predicting methane production in dairy cows [PDF]

, 2013
Methane is a potent greenhouse gas, to which enteric fermentation from ruminants contributes significantly. Reliable and accurate predictions of methane (CH₄) production from dairy cows would be of interest to develop mitigation strategies and for ...
Ramin, Mohammad
core   +1 more source

A novel biorelevant in vitro dynamic digestion simulator reproducing the biomechanics of the gastrointestinal tract Structure

, 2023
International audienceBackground: The biomechanics of the gastrointestinal tract strongly influence food disintegration and digestion in vivo. Most currently available in vitro dynamic digestion models lack, however, the ability of mimicking the oro ...
Feng, Jiajun, Lee, Jeehyun, Le Feunteun, Steven, Dupont, Didier, Greco, Ines, Jeantet, Romain   +5 more
core   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

In-vitro gastrointestinal digestion of kenaf seed oil-in-water nanoemulsions [PDF]

Industrial Crops and Products, 2016
Abstract The high nutrition value of kenaf seed oil has good potential to be used as functional foods or nutraceutical products. Kenaf seed oil-in-water nanoemulsions stabilised by ternary emulsifier mixtures, namely sodium caseinate, gum Arabic and Tween 20 were produced by using high pressure homogeniser.
Cheong, Ai Mun, Tan, Chin Ping, Nyam, Kar Lin   +2 more
openaire   +1 more source

Release of wheat gluten exorphins A5 and C5 during in vitro gastrointestinal digestion of bread and pasta and their absorption through an in vitro model of intestinal epithelium

, 2015
Pasta and bread provide energy and nutrients, but they also may represent a potential source of dietary bioactive substances. In this regard, attention has been paid to the physiological and pathological role of the gluten-derived peptides known as ...
M. Maggioni, M. Stuknytė, S. Cattaneo, P. De Luca, A. Ferraretto, I. De Noni   +5 more
core   +2 more sources