Results 71 to 80 of about 114,834,543 (300)
Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance
Advanced Science, EarlyView.Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer +9 more
wiley +1 more source
Digestive Stability of Xanthophylls Exceeds That of Carotenes As Studied in a Dynamic in Vitro Gastrointestinal System [PDF]
The Journal of Nutrition, 2009 Epidemiological studies have suggested that high consumption of tomato products is associated with a lower risk for chronic diseases. To exert their health effect, the phytochemicals of tomatoes have to be bioavailable and therefore it implies their stability through the digestion process.
Blanquet-Diot, Stéphanie +4 more
openaire +4 more sources
Digestibility of
BMC Veterinary Research, 2009 Background The use of Duddingtonia flagrans as a tool for the biological control of gastrointestinal nematodes (GIN) is a promising alternative to anthelmintics. The chlamydospores of D.
Mendoza-de-Gives Pedro +5 more
doaj +1 more source
Shipin gongye ke-ji, 2023 The impact of food nutrients on human health depends primarily on the digestion process in the gastrointestinal tract. The in vitro digestion model can simulate the digestive processes in vivo conditions integrally.
Chunna JIAO +7 more
doaj +1 more source
Pulsed electric field improved protein digestion of beef during in-vitro gastrointestinal simulation
, 2019 Effect of pulsed electric field (PEF) on in-vitro simulated gastrointestinal protein digestion of cold-boned beef Semimembranosus was elucidated. PEF treated [T₁, 5.0 kV (90 Hz); T₂, 10 kV (20 Hz)] samples along with control were subjected to in-vitro ...
Morton, James +3 more
core +1 more source
Advanced Science, EarlyView.Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang +9 more
wiley +1 more source
Human gastrointestinal conditions affect in vitro digestibility of peanut and bread proteins
Food & Function, 2020 Peanut and wheat proteins either isolated or within the food matrix were subjected to different static in vitro digestion models (infant, fed and fasted adult). Proteolysis differed across models.
Amelia Torcello-Gómez +7 more
openaire +5 more sources
Foods, 2023 The objective of this research was to encapsulate probiotics by alginate hydrogel beads based on an in situ cultivation method and investigate the influences on the cell loading capacity, surface and internal structure of hydrogel beads and in vitro ...
Yachun Huang +3 more
doaj +1 more source
Advanced Science, EarlyView.A schematic model summarizing GNA15's mechanism in mediating macrophage M2 polarization and Gemcitabine resistance. ABSTRACT The complexity of pancreatic ductal adenocarcinoma (PDAC) progression, coupled with the lack of effective immunotherapy, underscores the imperative to deepen our understanding of its mechanisms and identify suitable immune ...
Weihui Guo +8 more
wiley +1 more source
Gastrointestinal-active oligosaccharides from human milk and functional foods [PDF]
, 2011 Keywords: human milk oligosaccharides (HMOs), galacto-oligosaccharides (GOS), konjac glucomannan (KGM), breast milk, baby feces, gastrointestinal metabolization, blood-group specific conjugates, CE-LIF-MSn Oligosaccharides, as present in human milk ...
Albrecht, S.A.
core