Results 101 to 110 of about 114,819,952 (302)

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

The Financial Feasibility of Anaerobic Digestion for Ontario's Livestock Industries [PDF]

This report is an investigation of the financial feasibility of farm based anaerobic digestion investments under Ontario's Standard Offer Contract electricity prices.
Mallon, Shawn, Weersink, Alfons
core  

Effect of consumption temperature of whole milk on in vitro gastric digestion using a biomimetic digestion simulator

Food Research International
This study evaluates the effect of consumption temperature on the gastric digestion behaviour of whole milk using a dynamic in vitro model (NERDT™, computer-controlled biomimetic system). Human intragastric temperature profiles in response to cold, warm, and hot beverages were accurately reproduced to mimic the conditions encountered after consumption ...
Feng, Jiajun, Lee, Jeehyun, Mathieu, Vincent, Le Gouar, Yann, Jeantet, Romain, Dupont, Didier, Le Feunteun, Steven   +6 more
openaire   +2 more sources

In Vitro Simulated Digestion Characteristics of Pectin with Different Molecular Weights and Its Adsorption Performance for Pb2+

Shipin gongye ke-ji
Pectin is a highly promising biosorbent for heavy metals, however, its adsorption performance for these metals during human digestion remains unclear. This study aimed to investigate the structural changes of Citrus pectin with varying molecular weights ...
Chuan LUO, Hongyi LIU, Jun CHEN, Lizhen DENG, Taotao DAI, Ruihong LIANG, Ti LI, Yihui WANG, Risi WANG   +8 more
doaj   +1 more source

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

In-vitro digestion models : a critical review for human and fish and a protocol for in-vitro digestion in fish

, 2021
Digestive systems in human, animals, and fish are biological reactors and membranes to digest food and extract nutrients. Therefore, static and dynamic models of in-vitro digestion systems are developed to study e.g.
Taherzadeh, Mohammad J, Mohammadi, Mahtab, Wang, Ricky,, Mohammadi, Mahtab,, Taherzadeh, Mohammad J,, Mahboubi, Amir,, Wang, Ricky, Mahboubi, Amir   +7 more
core   +1 more source

In Vitro Simulated Digestion Evaluation of Full Nutrition Formula Powder for Sarcopenia in the Elderly

Shipin gongye ke-ji
This paper innovatively designed a full-nutrition formula powder based on the physiological characteristics of sarcopenia in the elderly. According to the digestive features of the elderly, an in vitro simulation of the oral-gastric-intestinal digestion ...
Wenjian ZHENG, Yu GUO, Qiancheng ZHAO, Bin QIU   +3 more
doaj   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Predicting methane production in dairy cows [PDF]

, 2013
Methane is a potent greenhouse gas, to which enteric fermentation from ruminants contributes significantly. Reliable and accurate predictions of methane (CH₄) production from dairy cows would be of interest to develop mitigation strategies and for ...
Ramin, Mohammad
core   +1 more source

The Prebiotic Activity of Simulated Gastric and Intestinal Digesta of Polysaccharides from the Hericium erinaceus

Molecules, 2018
Hericium erinaceus (HE) is a well-known edible and medicinal fungus widely grown in Asian countries. Polysaccharides from the Hericium erinaceus (HEP) are major biological macromolecules.
Yang Yang, Changhui Zhao, Mengxue Diao, Shuning Zhong, Maocheng Sun, Bo Sun, Haiqing Ye, Tiehua Zhang   +7 more
doaj   +1 more source