Results 81 to 90 of about 114,819,952 (302)
Advanced Science, EarlyView.This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang +11 more
wiley +1 more source
Current advances for in vitro protein digestibility
Frontiers in NutritionProtein is an essential macronutrient in our diet, source of nitrogen and essential amino acids, but the biological utilization of dietary protein depends on its digestibility and the absorption of amino acids and peptides in the gastrointestinal tract ...
Guillermo Santos-Sánchez +5 more
doaj +1 more source
Advanced Science, EarlyView.Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn +20 more
wiley +1 more source
Effect of pre-aeration and inoculum on the start-up of batch thermophilic anaerobic digestion of municipal solid waste [PDF]
, 2009 In this study, a short pre-aeration step was investigated as pre-treatment for thermophilic anaerobic digestion of the organic fraction of municipal solid waste (OFMSW).
Charles, W. +2 more
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Advanced Science, EarlyView.An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng +9 more
wiley +1 more source
Simulated Digestion of Polygonatum sibiricum Extract in Vitro and Its Effect on Intestinal Flora [PDF]
Objective: To explore the changes of active components in Polygonatum sibiricum extract and its regulation on intestinal flora by in vitro simulated digestion combined with 16S rDNA high-throughput sequencing technology. Methods: P. sibiricum extract was
Aixin CHANG +4 more
core +1 more source
LWT, 2019 Abstract This is a study of microstructure changes and Soybean milk colloidal particles degradation during in vitro digestion. Soybean milk passed through the digestion stages of the Infogest protocol, while its colloidal particles were examined in terms of size decrease/free surface evolution kinetics and of surface charge.
Weilin Liu +9 more
openaire +1 more source
AntioxidantsThis study compared the physicochemical properties of inulin caffeate, where caffeic acid (CA) was covalently bound to inulin (CA-Inu, degree of substitution: 0.07), with CA spray-dried inulin microparticles (Mp(CA/Inu)), as well as release profiles of ...
Patricio Romero-Hasler +5 more
doaj +1 more source
Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction
Advanced Science, EarlyView.In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng +12 more
wiley +1 more source
A multi-center peptidomic investigation of simulated gastrointestinal food digestion
, 2022 Background: Mass spectrometry has become the techniques of choice for the simultaneous assessment of a high variety of molecules in complex matrices. For this reason, it is best suited for precisely monitoring the evolution of digestive processes in vivo
P. Jimenez Barrios +21 more
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