Results 1 to 10 of about 27,668 (159)

Detection of in vivo mutagenicity in rat liver samples using error-corrected sequencing techniques [PDF]

Genes and Environment, 2023
Background Mutagenicity, the ability of chemical agents to cause mutations and potentially lead to cancer, is a critical aspect of substance safety assessment for protecting human health and the environment.
Kazuki Izawa, Masataka Tsuda, Takayoshi Suzuki, Masamitsu Honma, Kei-ichi Sugiyama   +4 more
doaj   +2 more sources

In vivo mutagenicity assessment of styrene in MutaMouse liver and lung [PDF]

Genes and Environment, 2023
Background Styrene (CAS 100-42-5) is widely used as polystyrene and acrylonitrile–butadiene–styrene resin such as plastic, rubber, and paint. One of the primary uses of styrene is food utensils and containers, but a small amount of styrene transferred ...
Yasumasa Murata, Masakatsu Natsume, Takako Iso, Yoshiyuki Shigeta, Nozomu Hirose, Takaaki Umano, Katsuyoshi Horibata, Kei-ichi Sugiyama, Kenichi Masumura, Akihiko Hirose, Mariko Matsumoto   +10 more
doaj   +2 more sources

In vivo mutagenicity assessment of orally treated tert-butyl hydroperoxide in the liver and glandular stomach of MutaMouse [PDF]

Genes and Environment, 2023
Background tert-Butyl hydroperoxide (TBHP; CAS 75–91-2), a hydroperoxide, is mainly used as a polymerization initiator to produce polyethylene, polyvinyl chloride, and unsaturated polyester.
Yasumasa Murata, Kenichiro Suzuki, Yoshiyuki Shigeta, Takako Iso, Nozomu Hirose, Takaaki Umano, Katsuyoshi Horibata, Kei-ichi Sugiyama, Akihiko Hirose, Kenichi Masumura, Mariko Matsumoto   +10 more
doaj   +2 more sources

Lack of in vivo mutagenicity of carbendazim in the liver and glandular stomach of MutaMice [PDF]

Genes and Environment
Background Carbendazim (methyl 2-benzimidazolecarbamate, CASRN: 10605-21-7) exhibits spindle poisoning effects and is widely used as a fungicide. With respect to genotoxicity, carbendazim is deemed to be non-mutagenic in vitro, but it causes indicative ...
Takako Iso, Kenichiro Suzuki, Yasumasa Murata, Nozomu Hirose, Takaaki Umano, Katsuyoshi Horibata, Kei-ichi Sugiyama, Akihiko Hirose, Kenichi Masumura, Mariko Matsumoto   +9 more
doaj   +2 more sources

New homozygous gpt delta transgenic rat strain improves an efficiency of the in vivo mutagenicity assay [PDF]

Genes and Environment, 2021
Background Gene mutation assays in transgenic rodents are useful tools to investigate in vivo mutagenicity in a target tissue. Using a lambda EG10 transgene containing reporter genes, gpt delta transgenic mice and rats have been developed to detect point
Kenichi Masumura, Tomoko Ando, Akiko Ukai, Sho Fujiwara, Shigeo Yokose, Xinyue You, Takayoshi Suzuki, Hiroyuki Hayashi, Takehiko Nohmi, Hisayoshi Takagi, Masamitsu Honma   +10 more
doaj   +2 more sources

Increased mutagenicity in the liver of MutaMouse females following oral treatment with commercial-grade toluene diisocyanate [PDF]

Genes and Environment
Background Toluene diisocyanates (TDIs) are high-production-volume chemicals widely used in polyurethane manufacturing. A typical commercial-grade TDI (TDI; 2,4-toluene diisocyanate: 2,6-toluene diisocyanate; 80:20), CAS: 26471-62-5, is mutagenic in ...
Mariko Matsumoto, Masakatsu Natsume, Takako Iso, Takaaki Umano, Yasumasa Murata, Kenichi Masumura, Katsuyoshi Horibata, Kei-ichi Sugiyama   +7 more
doaj   +2 more sources

Risk-based in silico mutagenic assessment of benzodiazepine impurities using three QSAR tools [PDF]

Toxicology Reports
Benzodiazepines, widely prescribed psychoactive drugs, may contain DNA-reactive (mutagenic) impurities formed during synthesis, posing significant health risks.
Srinivas Birudukota, Bhaskar Mangalapu, Ramesha Andagar Ramakrishna, Swagata Halder   +3 more
doaj   +2 more sources

Scientific Opinion on Flavouring Group Evaluation 205 (FGE.205):Consideration of genotoxicity data on representatives for 13 α,β-unsaturated aliphatic ketones with terminal double bonds and precursors from chemical subgroup 1.2.2 of FGE.19 by EFSA [PDF]

EFSA Journal, 2012
<p>The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider in the Flavouring Group Evaluation 205, the additional data on genotoxicity submitted by the Industry ...
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
doaj   +5 more sources

Biomolecules as Model Indicators of In Vitro and In Vivo Cold Plasma Safety

Frontiers in Physics, 2021
The potential applications for cold plasma in medicine are extensive, from microbial inactivation and induction of apoptosis in cancer cells to stimulating wound healing and enhancing the blood coagulation cascade.
Caitlin Heslin, Daniela Boehm, Brendan F. Gilmore, Julianne Megaw, Theresa A. Freeman, Noreen J. Hickok, P. J. Cullen, P. J. Cullen, Paula Bourke, Paula Bourke, Paula Bourke   +10 more
doaj   +1 more source

Evaluation of Mutagenicity and Anti-Mutagenicity of Various Bean Milks Using Drosophila with High Bioactivation

Foods, 2022
The consumption of a nutritious diet including phytochemicals can minimize mutations as the primary cause of carcinogenesis. Bean consumption supplies calories, minerals and phytochemicals but their anti-mutagenic properties in vivo remain little ...
Woorawee Inthachat, Uthaiwan Suttisansanee, Kalyarat Kruawan, Nattira On-Nom, Chaowanee Chupeerach, Piya Temviriyanukul   +5 more
doaj   +1 more source