Results 91 to 100 of about 27,781 (266)

A toxicity profile of the Pheroid® technology in rodents

Toxicology Reports, 2019
The Pheroid® drug delivery system is now on the threshold of progressing into human clinical trials for various patented pharmaceutical applications and a systematic investigation of its toxicological properties in vitro and in vivo is thus a priority ...
Janke Kleynhans, Dale Elgar, Thomas Ebenhan, Jan Rijn Zeevaart, Awie Kotzé, Anne Grobler   +5 more
doaj   +1 more source

The Use of Computational Methods in the Toxicological Assessment of Chemicals in Food: Current Status and Future Prospects [PDF]

, 2011
A wide range of chemicals are intentionally added to, or unintentially found in, food products, often in very small amounts. Depending on the situation, the experimental data needed to complete a dietary risk assessment, which is the scientific basis for
FUART GATNIK Mojca, LAPENNA SILVIA, LO PIPARO ELENA, MOSTRAG-SZLICHTYNG A., SERAFIMOVA ROSITSA, WORTH Andrew   +5 more
core   +1 more source

Development, qualification, validation and application of the Ames test using a VITROCELL® VC10® smoke exposure system

Toxicology Reports, 2018
The Ames test has established use in the assessment of potential mutagenicity of tobacco products but has generally been performed using partitioned exposures (e.g. total particulate matter [TPM], gas vapor phase [GVP]) rather than whole smoke (WS).
Kathy Fowler, Wanda Fields, Victoria Hargreaves, Lesley Reeve, Betsy Bombick   +4 more
doaj   +1 more source

Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme [PDF]

, 2017
Since the publication of the International Programme on Chemical Safety (IPCS) Harmonized Scheme for Mutagenicity Testing, there have been a number of publications addressing test strategies for mutagenicity.
Anderson, Diana, Anwar, Wagida A., Cimino, Michael C., Dobrev, Ivan, Douglas, George R., Eastmond, David A., Hartwig, Andrea, Nohmi, Takehiko, Phillips, David H., Vickers, Carolyn   +9 more
core  

Genotoxicity and Cytotoxicity Exerted by Pesticides in Different Biotic Matrices-An Overview of More Than a Decade of Experimental Evaluation [PDF]

, 2014
Agrochemicals represent one of the most important sources of environmental pollution. Although attempts to reduce agrochemical use through organic agricultural practices and the use of other technologies to control pests continue, the problem is still
Larramendy, Marcelo Luis, Nikoloff, Noelia, Ruiz de Arcaute, Celeste, Soloneski, Sonia Maria Elsa   +3 more
core   +2 more sources

Therapeutic Gene Editing: DNA Repair Pathways, Emerging Editors, and Clinical Progress

iNew Medicine, EarlyView.
ABSTRACT The field of gene editing has evolved rapidly over the past decade, progressing from programmable zinc‐finger nucleases (ZFNs) and transcription activator‐like effector nucleases (TALENs) to the widespread adoption of CRISPR‐Cas systems. First‐generation editors catalyzed genome engineering by introducing targeted double‐strand breaks (DSBs ...
Li‐Kuang Tsai, Youcai Xiong, Dongqi Liu, Dongshan Yang, Jifeng Zhang, Jie Xu, Renzhi Han, Y. Eugene Chen   +7 more
wiley   +1 more source

Toxicological evaluation of standardized Kaempferia parviflora extract: Sub-chronic and mutagenicity studies

Toxicology Reports, 2019
Kaempferia parviflora (KP), also known as Krachai-dam in Thailand, belongs to the family Zingiberaceae and has been used traditionally to improve blood flow and treat inflammatory, allergic, and gastrointestinal disorders. The objective of this study was
Susumu Yoshino, Riyo Awa, Nobuaki Ohto, Yasuo Miyake, Hiroshige Kuwahara   +4 more
doaj   +1 more source

Safety evaluation of substituted thiophenes used as flavoring ingredients. [PDF]

, 2016
This publication is the second in a series by the Expert Panel of the Flavor and Extract Manufacturers Association summarizing the conclusions of its third systematic re-evaluation of the safety of flavorings previously considered to be generally ...
Bastaki, M, Cohen, SM, Fukushima, S, Gooderham, NJ, Guengerich, FP, Harman, CL, Hecht, SS, McGowen, MM, Rietjens, IM, Smith, RL, Taylor, SV, Valerio, LG   +11 more
core   +1 more source

Abietic Acid Enhances the Sedative Activity of Diazepam: In vivo Approach along with Receptor Binding Affinity and Molecular Interaction with the GABAergic System

ChemistryOpen, EarlyView.
Abietic acid (AA) reveals potent sedative potential by expressing fast sleeping onset and increased sleeping duration compare to the control group in thiopental sodium induced sleeping mice. The compound also exhibited notable binding affinity (–7.9 kcal/mol) toward GABAA receptors.
Meher Afroz, Rubel Hasan, Mst Muslima Khatun, Mokammel Hossain Tito, Md Shadin, Ranjit Chakma, Mohammed Asiri, Faisal H. Altemani, Abdullah H. Altemani, Md Shimul Bhuia, Muhammad Torequl Islam   +10 more
wiley   +1 more source

Corrigendum: Biomolecules as Model Indicators of In Vitro and In Vivo Cold Plasma Safety

Frontiers in Physics, 2021
Caitlin Heslin, Daniela Boehm, Brendan F. Gilmore, Julianne Megaw, Theresa A. Freeman, Noreen J. Hickok, P. J. Cullen, P. J. Cullen, Paula Bourke, Paula Bourke, Paula Bourke   +10 more
doaj   +1 more source