Results 11 to 20 of about 27,781 (266)

In vivo and in vitro mutagenicity of perillaldehyde and cinnamaldehyde [PDF]

Genes and Environment, 2021
Background Perillaldehyde and cinnamaldehyde are natural substances found in plants that are used as flavoring ingredients. Due to the α,β-unsaturated aldehydes in their structures, these compounds are expected to be DNA reactive. Indeed, several reports
Masamitsu Honma, Masami Yamada, Manabu Yasui, Katsuyoshi Horibata, Kei-ichi Sugiyama, Kenichi Masumura   +5 more
doaj   +3 more sources

Benchmark Response (BMR) Values for In Vivo Mutagenicity Endpoints. [PDF]

Environ Mol Mutagen
ABSTRACTThe benchmark dose (BMD) approach constitutes the most effective and pragmatic strategy for the derivation of a point of departure (PoD) for comparative potency analysis, risk assessment, and regulatory decision‐making. There is considerable controversy regarding the most appropriate benchmark response (BMR) for genotoxicity endpoints.
White PA, Chen G, Chepelev N, Bell MA, Gallant LR, Johnson GE, Zeller A, Beal MA, Long AS.   +8 more
europepmc   +5 more sources

Mutagenicity of carcinogenic heterocyclic amines in Salmonella typhimurium YG strains and transgenic rodents including gpt delta

Genes and Environment, 2021
Chemical carcinogens to humans have been usually identified by epidemiological studies on the relationships between occupational or environmental exposure to the agents and specific cancer induction.
Takehiko Nohmi, Masahiko Watanabe
doaj   +1 more source

In Vitro versus In Vivo Metabolic Activation of Mutagens [PDF]

Environmental Health Perspectives, 1973
Mutagenicity testing is beginning to find a place as a factor in evaluation of the safety of compounds to which the human population is exposed. The mutation systems selected for such tests should ideally involve in vivo studies with mammals and encompass scoring of a broad spectrum of mutational events including both transmissible chromosome ...
H V, Malling, C N, Frantz
openaire   +2 more sources

Absence of mutagenicity of plants used to treat gastrointestinal disorders [PDF]

Archives of Biological Sciences, 2013
The Brazilian Savanna (locally called “Cerrado”) is an important biome presenting several plants that are used in popular medicine. However, the risks associated with the consumption of derivatives from these plants are generally unknown. Studies with
Santos F.V., Andreo M., Nasser A.L.M., Moreira L.M., Vilegas W., Cуlus I.M.S., Varanda E.A.   +6 more
doaj   +1 more source

Genotoxicity assessment of piperitenone oxide: an in vitro and in silico evaluation [PDF]

, 2017
Piperitenone oxide, a natural flavouring agent also known as rotundifolone, has been studied for the genotoxicity assessment by an integrated in vitro and in silico experimental approach, including the bacterial reverse mutation assay, the micronucleus ...
Abete, Lorena, Barile, Fabio, Bozovic, Mijat, DI GIACOMO, Silvia, DI SOTTO, Antonella, Izzo, Angelo A, Mazzanti, Gabriela, Parisi, Olga A, Ragno, Rino, Vitalone, Annabella   +9 more
core   +1 more source

CDK8/19 inhibition plays an important role in pancreatic β-cell induction from human iPSCs

Stem Cell Research & Therapy, 2023
Background Transplantation of differentiated cells from human-induced pluripotent stem cells (hiPSCs) holds great promise for clinical treatments. Eliminating the risk factor of malignant cell transformation is essential for ensuring the safety of such ...
Kensuke Sakuma, Noriko Tsubooka-Yamazoe, Kiyohiro Hashimoto, Nozomu Sakai, Shinya Asano, Saori Watanabe-Matsumoto, Takeshi Watanabe, Bunnai Saito, Hirokazu Matsumoto, Hikaru Ueno, Ryo Ito, Taro Toyoda   +11 more
doaj   +1 more source

The Degradation Product of Ramipril Is Potentially Carcinogenic, Genotoxic and Mutagenic

Applied Sciences, 2023
(1) Background: The aim of this study was to identify the degradation product of ramipril (RAM) formed under dry air and to verify its potential modes of carcinogenicity. We intended to check whether its formation and presence in final dosage forms could
Katarzyna Regulska, Agnieszka Matera-Witkiewicz, Aleksandra Mikołajczyk, Beata J. Stanisz   +3 more
doaj   +1 more source

In Vitro Mutagenic and Genotoxic Assessment of a Mixture of the Cyanotoxins Microcystin-LR and Cylindrospermopsin [PDF]

, 2019
The co-occurrence of various cyanobacterial toxins can potentially induce toxic effects different than those observed for single cyanotoxins, as interaction phenomena cannot be discarded. Moreover, mixtures are a more probable exposure scenario. However,
Cameán Fernández, Ana María, Díez-Quijada Jiménez, Leticia, Jos Gallego, Ángeles Mencía, Prieto Ortega, Ana Isabel, Puerto Rodríguez, María   +4 more
core   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source