Results 51 to 60 of about 27,781 (266)

Antimutagenic effect of curcumin and its effect on the immune response in mice

Czech Journal of Food Sciences, 2006
A wide array of antioxidative and anti-inflammatory substances derived from edible plants have been reported to possess chemopreventive and chemoprotective activities.
Petr Šmerák, Zdeňka Polívková, Helena Šestáková, Rudolf Štětina, Ivo Bárta, Martina Langová, Bohumil Turek, Jiřina Bártová   +7 more
doaj   +1 more source

The rate of X-ray-induced DNA double-strand break repair in the embryonic mouse brain is unaff ected by exposure to 50 Hz magnetic fi elds [PDF]

, 2015
Following in utero exposure to low dose radiation (10 – 200 mGy), we recently observed a linear induction of DNA double-strand breaks (DSB) and activation of apoptosis in the embryonic neuronal stem/progenitor cell compartment.
Ahlbom IC, Bayer SA, Brenner DJ, Cox J, Crumpton MJ, Ding GR, Draper G, Elizabeth Ainsbury, Fedele G, Gatz SA, Greenland S, International Agency for Research on Cancer (IARC), Ivancsits S, Jackie Haines, Kabacik S, Lagroye I, Lara Barazzuol, Lisa Woodbine, Luukkonen J, Luukkonen J, Maeda K, Mairs RJ, Margaret Coster, Mettler FA, Mitsuhashi T, O’Dea AR, Penny Jeggo, Pontious A, World Health Organization (WHO), Zenon Sienkiewicz, Zhao L   +30 more
core   +2 more sources

Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing

Advanced Science, EarlyView.
CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen, Hanlin Gou, Chao Xu, Sihan Wang, Huitao Zhang, Minglei Song, Mengge Wang, Xingkun Ji, Xiaofei Wei, Yuanyan Tan, Hehua Quan, Pengyu Luo, Hanyu Shou, Pengpeng Liu, Yafeng Liang, Jian‐Kang Zhu   +15 more
wiley   +1 more source

Assessments of Mutagenic and Genotoxic Effects of Noodles using Salmonella typhimurium and Caenorhabditis elegans as a Model Organism

UMYU Journal of Microbiology Research
Instant noodles are consumed globally in billions of servings, yet limited attention has been given to their potential genetic and reproductive toxicity.
Usman Usman Musa, Edith Adanna Onwuliri
doaj   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

H3 histamine receptor-mediated activation of protein kinase calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo [PDF]

, 2009
Histamine regulates functions via four receptors (HRH1, HRH2, HRH3, and HRH4). The D-myo-inositol 1,4,5-trisphosphate (IP(3))/Ca(2+)/protein kinase C (PKC)/mitogen-activated protein kinase pathway regulates cholangiocarcinoma growth.
A. Vetuschi, F. Y. Meng, FRANCHITTO, Antonio, G. Alpini, G. Carpino, GAUDIO, EUGENIO, H. Francis, J. Venter, M. White, MANCINELLI, ROMINA, ONORI, PAOLO, R. Sferra, S. Demorrow, S. Kopriva   +13 more
core   +1 more source

A test of the mutagenicity of cooked meats in vivo [PDF]

Mutagenesis, 2001
There is a correlation between intestinal cancer and diets high in meat, so fried beef, chicken, lamb, pork and fish were tested for their ability to induce mutations in the small intestine of mice. The mice were bred to be heterozygous at the Dlb-1 locus so that loss of the dominant Dlb-1 b allele by mutation could be detected.
J A, Heddle, M G, Knize, D, Dawod, X B, Zhang   +3 more
openaire   +2 more sources

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

EURL ECVAM strategy to avoid and reduce animal use in genotoxicity testing [PDF]

, 2013
The assessment of genotoxicity represents an important component of the safety assessment of all types of substances. Although several in vitro tests are available at different stages of development and acceptance, they cannot at present be considered to
CORVI Raffaella, MADIA FEDERICA, WHELAN Maurice, WORTH Andrew   +3 more
core   +1 more source

Pharmacogenetic CYP2B6 variants affect steroid hormone metabolism in human breast cancer cells

British Journal of Clinical Pharmacology, EarlyView.
Common genetic CYP2B6 variants correlate with adverse breast cancer outcome. The oestrogen metabolites estriol and 16‐epiestriol, which are formed downstream of CYP2B6‐catalysed 16α/β‐hydroxytestosterone, may be linked to elevated breast cancer risk and might increase due to the demonstrated CYP2B6 variants‐related metabolic shifts.
Marco Hoffmann, Julian Peter Müller, Stefan Düsterhöft, Sabrina Yamoune, Katja Susanne Just, Julia Carolin Stingl   +5 more
wiley   +1 more source