Results 71 to 80 of about 27,781 (266)

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

The Assessment of the Biocompatibility of Dental Alloys and Alloys for Dental Amalgam. Part Second

Česká Stomatologie a Praktické Zubní Lékařství, 2014
Background: The second part of the literature review on the biocompatibility of dental alloys is focused to their possible sensibilizing effects, mutagenicity and carcinogenicity and the methods of their testing.
Z. Broukal, V. Fialová, J. Novotný
doaj   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Genotoxicity and 28-day repeated dose oral toxicity study of ovatodiolide in rats

Toxicology Reports, 2021
Ovatodiolide is a bioactive cembrane-type diterpenoid isolated from Anisomeles indica (L.) Kuntze. It has been proven that ovatodiolide is anti-inflammatory, anti-tumorigenic, anti-melanogenic and attenuates asthma by regulating signaling pathways.
Jing-Chun Chen, Yan-Zhen Dai, Yew-Min Tzeng, Jiunn-Wang Liao   +3 more
doaj   +1 more source

Biocompatibility and antibacterial properties of zirconium nitride coating on titanium abutments: An in vitro study [PDF]

, 2018
Improving soft tissue attachment and reducing bacterial colonization on titanium abutments are key factors for the long-term maintenance of healthy soft and hard peri-implant tissues.
Bressan, Eriberto, Brun, Paola, Brunello, Giulia, Ferroni, Letizia, Gardin, Chiara, Meneghello, Roberto, Sivolella, Stefano, Zavan, Barbara   +7 more
core   +2 more sources

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Characterization and genotoxicity evaluation of effluent from a pharmacy industry

Revista Ambiente & Água, 2013
The pharmaceutical, textile and food industry bear much of the responsibility for environmental pollution. In order to appropriately treat and mitigate the effects of pharmaceutical effluent, it is necessary to study it in order to determine its physical
Hélio Mendes de Oliveira Júnior, Paulo de Tarso Ferreira Sales, Danyllo Bueno de Oliveira, Fernando Schimidt, Mariângela Fontes Santiago, Luiza Cintra Campos   +5 more
doaj   +1 more source

Mutagenicity and genotoxicity of isatin in mammalian cells in vivo

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2011
Isatin (1H-indole-2,3-dione) is a synthetically versatile substrate used for the synthesis of heterocyclic compounds and as a raw material for drug synthesis. Isatin and its derivatives demonstrate anticonvulsant, antibacterial, antifungal, antiviral, and anticancer properties.
Candido-Bacani, Priscila de Matos, dos Reis, Mariana Bisarro, Serpeloni, Juliana Mara, Calvo, Tamara Regina, Vilegas, Wagner, Varanda, Eliana Aparecida, de Syllos Colus, Ilce Mara   +6 more
openaire   +3 more sources

Evaluation of the standard battery of in vitro genotoxicity tests to predict in vivo genotoxicity through mathematical modeling: A report from the 8th International Workshop on Genotoxicity Testing

Environmental and Molecular Mutagenesis, EarlyView.
Abstract In human health risk assessment of chemicals and pharmaceuticals, identification of genotoxicity hazard usually starts with a standard battery of in vitro genotoxicity tests, which is needed to cover all genotoxicity endpoints. The individual tests included in the battery are not designed to pick up all endpoints.
Mirjam Luijten, Jan van Benthem, Takeshi Morita, Raffaella Corvi, Patricia A. Escobar, Yurika Fujita, Jennifer Hemmerich, Naveed Honarvar, David Kirkland, Naoki Koyama, David P. Lovell, Miriam Mathea, Andrew Williams, Stephen Dertinger, Stefan Pfuhler, Jeroen L. A. Pennings   +15 more
wiley   +1 more source

Evaluation of cytotoxicity and mutagenicity of the benzodiazepine flunitrazepam in vitro and in vivo

Brazilian Journal of Pharmaceutical Sciences, 2014
Flunitrazepam (FNZ) is a sedative benzodiazepine prescribed for the short-term treatment of insomnia. However, there are concerns regarding possible carcinogenic or genotoxic effects of this medicine.
Igor Vivian de Almeida, Giovana Domingues, Lilian Capelari Soares, Elisângela Düsman, Veronica Elisa Pimenta Vicentini   +4 more
doaj   +1 more source