Results 1 to 10 of about 49,383 (204)

Microbiota-Derived Tryptophan Metabolite Indole-3-Propionic Acid-Emerging Role in Neuroprotection [PDF]

Molecules
In recent years, gut–brain axis signaling has been recognized as an essential factor modifying behavior, mood, cognition, and cellular viability under physiological and pathological conditions.
Maja Owe-Larsson, Dominik Drobek, Paulina Iwaniak, Renata Kloc, Ewa M. Urbanska, Mirosława Chwil   +5 more
doaj   +5 more sources

Indole-3-propionic acid promotes hepatic stellate cells inactivation [PDF]

Journal of Translational Medicine
Background & aims We have previously reported that the serum levels of gut-derived tryptophan metabolite indole-3-propionic acid (IPA) are lower in individuals with liver fibrosis.
Mariana Ilha, Ratika Sehgal, Johanna Matilainen, Kirsi Rilla, Dorota Kaminska, Shrey Gandhi, Ville Männistö, Charlotte Ling, Stefano Romeo, Päivi Pajukanta, Eija Pirinen, Kirsi A. Virtanen, Kirsi H. Pietiläinen, Maija Vaittinen, Jussi Pihlajamäki   +14 more
doaj   +7 more sources

The Mechanism Underlying the Influence of Indole-3-Propionic Acid: A Relevance to Metabolic Disorders [PDF]

Frontiers in Endocrinology, 2022
The increasing prevalence of metabolic syndrome has become a serious public health problem. Certain bacteria-derived metabolites play a key role in maintaining human health by regulating the host metabolism.
Binbin Zhang, Binbin Zhang, Minjie Jiang, Jianan Zhao, Yu Song, Weidong Du, Junping Shi, Junping Shi   +7 more
doaj   +5 more sources

Indole-3-Propionic Acid as a Potential Therapeutic Agent for Sepsis-Induced Gut Microbiota Disturbance [PDF]

Microbiology Spectrum, 2022
The effects of using gut microbiota metabolites instead of live microorganisms to modulate sepsis-induced gut dysbiosis remain largely unknown. We assessed the effects of microbiota metabolite indole-3-propionic acid (IPA) on gut microbiota in mice ...
Heng Fang, Miaoxian Fang, Yirong Wang, Huidan Zhang, Jiaxin Li, Jingchun Chen, Qingrui Wu, Linling He, Jing Xu, Jia Deng, Mengting Liu, Yiyu Deng, Chunbo Chen   +12 more
doaj   +5 more sources

The Neuroprotective Role of Indole-3-Propionic Acid in Migraine Pathophysiology [PDF]

Medicina
Background and Objectives: Migraine is a leading cause of disability worldwide, with complex pathophysiological mechanisms involving oxidative and nitrosative stress.
Dilek Agircan, Seyhan Taskin, Murat Cekic, Hakim Celik   +3 more
doaj   +4 more sources

New Indole-3-Propionic Acid and 5-Methoxy-Indole Carboxylic Acid Derived Hydrazone Hybrids as Multifunctional Neuroprotectors [PDF]

Antioxidants, 2023
In light of the known neuroprotective properties of indole compounds and the promising potential of hydrazone derivatives, two series of aldehyde-heterocyclic hybrids combining those pharmacophores were synthesized as new multifunctional neuroprotectors.
Neda Anastassova, Denitsa Stefanova, Nadya Hristova-Avakumova, Irina Georgieva, Magdalena Kondeva-Burdina, Miroslav Rangelov, Nadezhda Todorova, Rumiana Tzoneva, Denitsa Yancheva   +8 more
doaj   +5 more sources

Gut Metabolite Indole‐3‐Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging‐Related Myocardial Fibrosis [PDF]

Advanced Science
Cardiac fibrosis, a key pathological feature of cardiac remodeling, is a major contributor to mortality in older patients with heart failure. The underlying mechanisms are complex, involving alterations in intercellular communication and chronic ...
Jing Lu, Hongyan Wang, Haiyu Zhang, Jiahao Li, Hanqi Li, Qiuyu Chen, Dongyu Han, Jialiang Liu, Lin Lv, Jie Xiong, Keying Yuan, Xianpeng Wei, Siqi Sheng, Fukai Liu, Yuanqi Shi, Zengxiang Dong, Yue Li   +16 more
doaj   +3 more sources

Indole-3-propionic acid supplementation during in vitro maturation improves in vitro production of porcine embryos [PDF]

BMC Veterinary Research
Background Oxidative stress is a critical factor affecting the maturation and developmental competence of porcine oocytes during in vitro culture, reducing the efficiency of blastocyst formation. Antioxidant supplementation in the culture medium has been
Yuichiro Nakayama, Takeshige Otoi, Namula Zhao, Suong Thi Nguyen, Nanaka Torigoe, Qyingi Lin, Liu Bin, Oky Setyo Widodo, Theerawat Tharasanit, Kaywalee Chatdarong, Maki Hirata, Megumi Nagahara, Fuminori Tanihara   +12 more
doaj   +3 more sources

Gut microbial metabolite indole-3-propionic acid inhibits inflammation and restores blood-milk barrier in S. aureus- induced mastitis by targeting aryl hydrocarbon receptor [PDF]

Frontiers in Microbiology
BackgroundIndole-3-propionic acid (IPA) is a tryptophan metabolite produced by intestinal bacteria, which has functions such as penetrating tissue barriers and reducing tissue inflammatory reactions. In the present study, the therapeutic effect of IPA on
Lihua Zhao, Lei Jin, Yunhe Fu, Bin Yang
doaj   +2 more sources

Sorafenib versus Lenvatinib Causes Stronger Oxidative Damage to Membrane Lipids in Noncancerous Tissues of the Thyroid, Liver, and Kidney: Effective Protection by Melatonin and Indole-3-Propionic Acid [PDF]

Biomedicines, 2022
Sorafenib and lenvatinib are multi-targeted tyrosine kinase inhibitors which are currently approved to treat advanced hepatocellular carcinoma, renal cell carcinoma and radioiodine-refractory differentiated thyroid carcinoma.
Jan Stępniak, Joanna Krawczyk-Lipiec, Andrzej Lewiński, Małgorzata Karbownik-Lewińska   +3 more
doaj   +2 more sources