Results 11 to 20 of about 49,383 (204)

Indole-3-propionic acid alleviates chondrocytes inflammation and osteoarthritis via the AhR/NF-κB axis [PDF]

Molecular Medicine, 2023
Background Osteoarthritis (OA) is a common chronic disease characterized by chronic inflammation and extracellular matrix degradation. Indole-3-propionic acid (IPA) is a tryptophan metabolite secreted by intestinal flora, which can exert anti ...
Huangming Zhuang, Xunshan Ren, Fuze Jiang, Panghu Zhou   +3 more
doaj   +5 more sources

Quercetin ameliorates obesity and inflammation via microbial metabolite indole-3-propionic acid in high fat diet-induced obese mice [PDF]

Frontiers in Nutrition
BackgroundObesity is a chronic metabolic disease, mainly caused by excessive/abnormal fat accumulation, as well as accompanied by endotoxemia and chronic inflammation. Quercetin, a natural flavonoid, may alleviate obesity by regulating gut microbiota and
Jiaxin Lu, Yanting Huang, Yujing Zhang, Jiayu Xie, Qingjun Guo, Huifan Yang, Yunyan Yang, Jing Chen, Lijie Su   +8 more
doaj   +3 more sources

Gut-Derived Metabolite Indole-3-Propionic Acid Modulates Mitochondrial Function in Cardiomyocytes and Alters Cardiac Function [PDF]

Frontiers in Medicine, 2021
Background: The gut microbiome has been linked to the onset of cardiometabolic diseases, in part facilitated through gut microbiota-dependent metabolites such as trimethylamine-N-oxide.
Maren Gesper, Alena B. H. Nonnast, Nina Kumowski, Robert Stoehr, Katharina Schuett, Nikolaus Marx, Ben A. Kappel   +6 more
doaj   +5 more sources

Indole-3-propionic acid regulates lateral root development by targeting auxin signaling in Arabidopsis [PDF]

iScience
Summary: Indole-3-propionic acid (IPA) is known to be a microbe-derived compound with a similar structure to the phytohormone auxin (indole-3-acetic acid, IAA). Previous studies reported that IPA exhibited auxin-like bioactivities in plants. However, the
Yue Sun, Zhisen Yang, Caoli Zhang, Jing Xia, Yawen Li, Xin Liu, Linfeng Sun, Shutang Tan   +7 more
doaj   +4 more sources

Indole-3-propionic acid alleviates sepsis-associated acute liver injury by activating pregnane X receptor [PDF]

Molecular Medicine, 2023
Background The morbidity and mortality of sepsis are extremely high, which is a major problem plaguing human health. However, current drugs and measures for the prevention and treatment of sepsis have little effect.
Shuang Wang, Liangzhi Xiong, Zhihua Ruan, Xiaofang Gong, Yanrong Luo, Chengyi Wu, Yu Wang, Hui Shang, Jingyi Chen   +8 more
doaj   +4 more sources

Esterified Indole-3-propionic Acid: A Novel Inhibitor against Cholinesterase Identified through Experimental and Computational Approaches [PDF]

ACS Omega
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are targeted for designing drugs against cognitive dysfunction. Curcumin (CUR) and indole-3-propionic acid (IPA) are known for their neuroprotective activity. The clinical application of CUR is hindered due to poor absorption and bioavailability. Hence, CUR was conjugated with IPA to form the
Jayanthi Sidhambaram, Penislusshiyan Sakayanathan, Chitra Loganathan, Ancy Iruthayaraj, Palvannan Thayumanavan   +4 more
doaj   +5 more sources

Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats [PDF]

Experimental and Molecular Medicine, 2019
Fatty liver disease: Bacterial metabolite protects liver by maintaining gut integrity A molecule made by beneficial microbes in the gut helps protect against a severe form of fatty liver disease by preventing bacterial toxins from leaking out of the ...
Ze-Hua Zhao, Feng-Zhi Xin, Yaqian Xue, Zhimin Hu, Yamei Han, Fengguang Ma, Da Zhou, Xiao-Lin Liu, Aoyuan Cui, Zhengshuai Liu, Yuxiao Liu, Jing Gao, Qin Pan, Yu Li, Jian-Gao Fan   +14 more
doaj   +4 more sources

Gut microbiota-derived indole 3-propionic acid partially activates aryl hydrocarbon receptor to promote macrophage phagocytosis and attenuate septic injury [PDF]

Frontiers in Cellular and Infection Microbiology, 2022
Sepsis is associated with a high risk of death, and the crosstalk between gut microbiota and sepsis is gradually revealed. Indole 3-propionic acid (IPA) is a gut microbiota-derived metabolite that exerts immune regulation and organ protective effects ...
Zhi-Bin Huang, Zhi-Bin Huang, Zhen Hu, Chen-Xin Lu, Si-Dan Luo, Yu Chen, Yu Chen, Zhi-Peng Zhou, Zhi-Peng Zhou, Jing-Juan Hu, Fang-Ling Zhang, Fan Deng, Ke-Xuan Liu   +12 more
doaj   +3 more sources

Engineered probiotic-derived indole-3-propionic acid inhibits ubiquitination via AHR signaling to treat postmenopausal osteoporosis [PDF]

Gut Microbes
Postmenopausal osteoporosis (PMOP) has a high incidence in middle-aged and elderly women, leading to an increased risk of fractures and elevated rates of disability and mortality. In this work, we identified the reduction of indole-3-propionic acid (IPA)
Xueli Qiu, Lijun Wu, Fengxian Jiang, Huajian Shan, Lei Sheng, Bo Tian, Heng Wang, Hao Cui, Lide Tao, Chenyang Wu, Yuqian Yao, Chao Wang, Xiaozhong Zhou, Yingzi Zhang, Jinyu Bai   +14 more
doaj   +3 more sources

Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction. [PDF]

Circ Res
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a common but poorly understood form of heart failure, characterized by impaired diastolic function. It is highly heterogeneous with multiple comorbidities, including obesity and diabetes, making human studies difficult ...
Wang YC, Koay YC, Pan C, Zhou Z, Tang W, Wilcox J, Li XS, Zagouras A, Marques F, Allayee H, Rey FE, Kaye DM, O'Sullivan JF, Hazen SL, Cao Y, Lusis AJ.   +15 more
europepmc   +6 more sources