Results 21 to 30 of about 49,383 (204)

Modulation of Host Immunity by Microbiome-Derived Indole-3-Propionic Acid and Other Bacterial Metabolites. [PDF]

Eur J Immunol
ABSTRACT In recent years, we have witnessed a rapidly growing interest in the intricate communications between intestinal microorganisms and the host immune system. Research on the human microbiome is evolving from merely descriptive and correlative studies to a deeper mechanistic understanding of the bidirectional interactions ...
Schütz B, Krause FF, Taudte RV, Zaiss MM, Luu M, Visekruna A.   +5 more
europepmc   +5 more sources

Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis. [PDF]

Nutrients, 2021
Background and Aims: Gut microbiota-derived metabolites play a vital role in maintenance of human health and progression of disorders, including obesity and type 2 diabetes (T2D). Indole-3-propionic acid (IPA), a gut-derived tryptophan metabolite, has been recently shown to be lower in individuals with obesity and T2D.
Sehgal R, Ilha M, Vaittinen M, Kaminska D, Männistö V, Kärjä V, Tuomainen M, Hanhineva K, Romeo S, Pajukanta P, Pihlajamäki J, de Mello VD.   +11 more
europepmc   +6 more sources

Indole-3-propionic acid enhances growth performance and reduces diarrhea via modulating redox status and intestinal inflammation in weaned piglets [PDF]

Animal Nutrition
Indole-3-propionic acid (IPA) has anti-inflammatory properties, which can be beneficial for weaned piglets with underdeveloped immune systems. The study explores the impact of IPA supplementation on growth performance, oxidative stress, and inflammation ...
Dongxu Ming, Xincong Xu, Xianren Jiang, Yanpin Li, Wenjuan Sun, Jiangbo Xiang, Mingyuan Huang, Yu Pi, Xilong Li   +8 more
doaj   +2 more sources

Potential role of indole-3-propionic acid in tuberculosis: current perspectives and future prospects

Expert Opinion on Therapeutic Targets
Indole-3-propionic acid (IPA), a tryptophan catabolite derived from gut bacterial metabolism, has been identified as a functional link between the gut microbiome and tuberculosis.IPA has gained ample attention over the past two decades on account of its multiple physiological roles, besides being both detectable and quantifiable.
Tejaswini Baral, Aieshel Serafin Johnson, Mazhuvancherry Kesavan Unnikrishnan, Mohan K. Manu, Kavitha Saravu, Chandrashekar Udyavara Kudru, Suhaj Abdulsalim, Jitendra Singh, Chiranjay Mukhopadhyay, Mahadev Rao, Sonal Sekhar Miraj   +10 more
openaire   +3 more sources

The Tryptophan Metabolite Indole-3-Propionic Acid Raises Kynurenic Acid Levels in the Rat Brain In Vivo. [PDF]

Int J Tryptophan Res
Alterations in the composition of the gut microbiota may be causally associated with several brain diseases. Indole-3-propionic acid (IPrA) is a tryptophan-derived metabolite, which is produced by intestinal commensal microbes, rapidly enters the circulation, and crosses the blood-brain barrier.
Sathyasaikumar KV, Blanco-Ayala T, Zheng Y, Schwieler L, Erhardt S, Tufvesson-Alm M, Poeggeler B, Schwarcz R.   +7 more
europepmc   +5 more sources

Biochemical and embryocidal side effects of indole-3-propionic acid and indole-3-butyric acid on albino mice (Mus musculus var. albus)

Journal of Basic and Applied Zoology
Background Phytohormones as indole-3-propionic acid (IPA) and indole-3-butyric acid (IBA) are commonly used in several agricultural purposes. Some negative effects may have appeared due to their uses to mammals.
Ahmed S. Abdel-Aty, Mohamed A. Desheesh, Mariam M. Khattab, Khadega I. Hassan   +3 more
doaj   +2 more sources

The Gut Microbiota-Produced Indole-3-Propionic Acid Confers the Antihyperlipidemic Effect of Mulberry-Derived 1-Deoxynojirimycin

mSystems, 2020
Hyperlipidemia is a worldwide epidemic with an obvious gender disparity in incidence. Modulations on gut microbiota by traditional Chinese medicines (TCM) are emerging as a potential rationale governing the profitable effects of drugs on hyperlipidemia ...
Yougui Li, Wenyi Xu, Fang Zhang, Shi Zhong, Yuqing Sun, Jinxi Huo, Jianxun Zhu, Chongming Wu   +7 more
doaj   +3 more sources

Biological Effects of Indole-3-Propionic Acid, a Gut Microbiota-Derived Metabolite, and Its Precursor Tryptophan in Mammals' Health and Disease. [PDF]

Int J Mol Sci, 2022
Actions of symbiotic gut microbiota are in dynamic balance with the host’s organism to maintain homeostasis. Many different factors have an impact on this relationship, including bacterial metabolites.
Konopelski P, Mogilnicka I.
europepmc   +2 more sources

Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice. [PDF]

Nat Commun
Anti-programmed death 1 (αPD1) immune checkpoint blockade is used in combination for cancer treatment but associated with cardiovascular toxicity. Leflunomide (Lef) can suppress the growth of several tumor and mitigate cardiac remodeling in mice. However,
Huang R, Shen ZY, Huang D, Zhao SH, Dan LX, Wu P, Tang QZ, Ma ZG.   +7 more
europepmc   +2 more sources

Microbiota-indole 3-propionic acid-brain axis mediates abnormal synaptic pruning of hippocampal microglia and susceptibility to ASD in IUGR offspring. [PDF]

Microbiome, 2023
Background Autism spectrum disorder (ASD) has been associated with intrauterine growth restriction (IUGR), but the underlying mechanisms are unclear. Results We found that the IUGR rat model induced by prenatal caffeine exposure (PCE) showed ASD-like ...
Wang T, Chen B, Luo M, Xie L, Lu M, Lu X, Zhang S, Wei L, Zhou X, Yao B, Wang H, Xu D.   +11 more
europepmc   +2 more sources