Results 31 to 40 of about 49,383 (204)

Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4⁺ T cells to confer protection against intestinal inflammation. [PDF]

Nat Metab
The gut microbiota and its metabolites critically regulate immune cell phenotype, function and energy metabolism. We screened a collection of gut microbiota-related metabolites to identify modulators of mitochondrial metabolism in T cells.
Li Q, de Oliveira Formiga R, Puchois V, Creusot L, Ahmad AH, Amouyal S, Campos-Ribeiro MA, Zhao Y, Harris DMM, Lasserre F, Ellero-Simatos S, Guillou H, Huang Z, Brot L, Hu Y, Chollet L, Danne C, Scandola C, Ledent T, Chevreux G, Argüello RJ, De Carvalho Bittencourt M, Bettinger J, D'Aveni-Piney M, Moulin D, Schreiber S, Aden K, Rolhion N, Michel ML, Wai T, Sokol H.   +30 more
europepmc   +2 more sources

Indole-3-Propionic Acid, a Gut Microbiota Metabolite, Protects Against the Development of Postoperative Delirium. [PDF]

Ann Surg, 2023
Objective: The aim was to determine preoperative gut microbiota metabolites that may be associated with postoperative delirium (POD) development in patients and further study in rodents. Summary Background Data: POD occurs in 9% to 50% of older patients undergoing anesthesia/surgery
Zhou X, Wu X, Wu Y, Yang L, Shi E, Ding W, Chen L, Shi X, Feng X, Su C, You Z, Xia J, Chen C, Yeliseyev V, Bry L, Xia S, Huang P, Meng J, Houle T, Akeju O, Mao J, Gerszten R, Chen Q, Xie Z, Shen S.   +24 more
europepmc   +3 more sources

Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and Its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease

Circulation Research, 2022
Background: Accumulating evidence has shown that disorders in the gut microbiota and derived metabolites affect the development of atherosclerotic cardiovascular disease (ASCVD). However, which and how specific gut microbial metabolites contribute to the
Hongliang Xue, Xu Chen, Chao Yu, Yuqing Deng, Yuan Zhang, Shen Chen, Xuechen Chen, Ke Chen, Yan Yang, W. Ling   +9 more
semanticscholar   +1 more source

Gut microbiota-derived metabolites in inflammatory diseases based on targeted metabolomics

Frontiers in Pharmacology, 2022
The gut microbiota plays an important role in inflammatory diseases. Metabolites in the three metabolic pathways of tryptophan (Trp), histidine (His), and phenylalanine (Phe) can affect various inflammatory conditions, such as obesity, diabetes ...
Hui Xu, Li-Bin Pan, Hang Yu, Pei Han, Jie Fu, Zheng-Wei Zhang, Jia-Chun Hu, Xin-Yu Yang, Adili Keranmu, Hao-Jian Zhang, Meng-Meng Bu, Jian-Dong Jiang, Yan Wang   +12 more
doaj   +1 more source

Hydrogen-deuterium exchange of indole-3-propionic acid with deuterated trifluoromethanesulfonic acid

Arkivoc, 2022
Indole-3-propionic acid (IPA), a member of the plant auxin family, plays an important role in biological activity. There are few reports on the preparation of deuterated IPA. Deuterated trifluoromethanesulfonic acid (TfOD) is a hydrogen-deuterium exchange reagent used for aromatic compounds.
Zhang, Wen, Tachrim, Zetryana Puteri, Tokoro, Yurika, Wang, Zeping, Ishikawa, Shoko, Murai, Yuta, Suzuki, Takeyuki, Hashimoto, Makoto   +7 more
openaire   +2 more sources

Sedentary Plant-Parasitic Nematodes Alter Auxin Homeostasis via Multiple Strategies

Frontiers in Plant Science, 2021
Sedentary endoparasites such as cyst and root-knot nematodes infect many important food crops and are major agro-economical pests worldwide. These plant-parasitic nematodes exploit endogenous molecular and physiological pathways in the roots of their ...
Matthijs Oosterbeek, Jose L. Lozano-Torres, Jaap Bakker, Aska Goverse   +3 more
doaj   +1 more source

The gut microbiota-derived metabolite indole-3-propionic acid enhances leptin sensitivity by targeting STAT3 against diet-induced obesity. [PDF]

Clin Transl Med
Obesity is associated with the gut microbiome. Here, we report that gut commensal Clostridia bacteria regulate host energy balance through the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA).
Wang Z, Yang S, Liu L, Mao A, Kan H, Yu F, Ma X, Feng L, Zhou T.   +8 more
europepmc   +2 more sources

Bioconversion of Biologically Active Indole Derivatives with Indole-3-Acetic Acid-Degrading Enzymes from Caballeronia glathei DSM50014

Biomolecules, 2020
A plant auxin hormone indole-3-acetic acid (IAA) can be assimilated by bacteria as an energy and carbon source, although no degradation has been reported for indole-3-propionic acid and indole-3-butyric acid.
Mikas Sadauskas, Roberta Statkevičiūtė, Justas Vaitekūnas, Rolandas Meškys   +3 more
doaj   +1 more source

Influence of blood meal on the responsiveness of olfactory receptor neurons in antennal sensilla trichodea of the yellow fever mosquito, Aedes aegypti [PDF]

, 2010
In female Aedes aegypti L. mosquitoes, a blood meal induces physiological and behavioral changes. Previous studies have shown that olfactory receptor neurons (ORNs) housed in grooved peg sensilla on the antennae of Ae.
Hansson, Bill, Hill, Sharon, Ignell, Rickard, Siju, K.P.   +3 more
core   +1 more source

Baitouweng decoction modulates gut microbial production of indole-3-propionic acid and epithelial necroptosis to alleviate DSS-induced colitis in mice. [PDF]

Chin Med
Ulcerative colitis (UC) is a kind of inflammatory disorder structuring in the colon. Baitouweng decoction (BD) derived from Treatise on Cold Damage (Shang-Han-Lun in Chinese) has been used for the treatment of UC in clinical practice for more than 2000 ...
Hu J, Chen H, Zhu L, Tong Y, Cheng C, Yan G, Shen H.   +6 more
europepmc   +2 more sources