Results 41 to 50 of about 49,383 (204)

Development of indole-3-propionic acid (OXIGON™) for alzheimer’s disease

Journal of Molecular Neuroscience, 2002
The accumulation of amyloid-beta and concomitant oxidative stress are major pathogenic events in Alzheimer's disease. Indole-3-propionic acid (IPA, OXIGON) is a potent anti-oxidant devoid of pro-oxidant activity. IPA has been demonstrated to be an inhibitor of beta-amyloid fibril formation and to be a potent neuroprotectant against a variety of ...
Bendheim, P. E., Poeggeler, Burkhard, Neria, E., Ziv, V., Pappolla, Miguel A., Chain, D. G.   +5 more
openaire   +3 more sources

Production of Indole-3-Lactic Acid by Bifidobacterium Strains Isolated fromHuman Infants

Microorganisms, 2019
Recent studies have shown that metabolites produced by microbes can be considered as mediators of host-microbial interactions. In this study, we examined the production of tryptophan metabolites by Bifidobacterium strains found in the gastrointestinal ...
Takuma Sakurai, Toshitaka Odamaki, Jin-zhong Xiao   +2 more
doaj   +1 more source

Synthesis, Characterization and Antibacterial Activity Evaluation of New Indole-Based Derivatives

Iraqi Journal of Pharmaceutical Sciences, 2020
A new series of N-acyl hydrazones (4a-g) derived from indole-3-propionic acid (IPA) were synthesized. These N-acyl hydrazones were prepared by the reaction of 3-(1H-indol-3-yl) propane hydrazide and aldehyde in the existence of glacial acetic acid as a ...
Ahmed T. Sulaiman, Susan W. Sarsam
doaj   +1 more source

Indole-3-Propionic Acid, a Tryptophan-Derived Bacterial Metabolite, Reduces Weight Gain in Rats [PDF]

Nutrients, 2019
Recent evidence suggests that tryptophan, an essential amino acid, may exert biological effects by means of tryptophan-derived gut bacteria products. We evaluated the potential contribution of tryptophan-derived bacterial metabolites to body weight gain.
Piotr Konopelski, Marek Konop, Marta Gawrys-Kopczynska, Piotr Podsadni, Agnieszka Szczepanska, Marcin Ufnal   +5 more
openaire   +2 more sources

Gut microbiota indole-3-propionic acid mediates neuroprotective effect of probiotic consumption in healthy elderly: A randomized, double-blind, placebo-controlled, multicenter trial and in vitro study.

Clinical Nutrition, 2023
BACKGROUND & AIMS The beneficial effects of probiotic consumption on age-related decline in cerebral function have been previously reported in the literature; however, the mechanistic link between gut and brain interactions has not yet been fully ...
Chong-Su Kim, Sunhee Jung, Geum-Sook Hwang, Dong-Mi Shin   +3 more
semanticscholar   +1 more source

Response of pine hypocotyl sections to growth regulators and related substances

Acta Societatis Botanicorum Poloniae, 2015
Growth response of Pinus silvestris hypocotyl sections to some synthetic growth regulators and related substances was studied. Elongation of hypocotyl sections was stimulated by naphtaleneacetic acid, indole-3-acetic acid, in-dole-3-propionic acid ...
J. Zakrzewski
doaj   +1 more source

Determination of Tryptophan Metabolites in Serum and Cerebrospinal Fluid Samples Using Microextraction by Packed Sorbent, Silylation and GC–MS Detection

Molecules, 2020
Indole-containing acids—tryptophan metabolites—found in serum and cerebrospinal fluid (CSF) samples of patients with diseases of the central nervous system (CNS) were determined with the use of microextraction by packed sorbent (MEPS) followed by ...
Alisa Pautova, Zoya Khesina, Maria Getsina, Pavel Sobolev, Alexander Revelsky, Natalia Beloborodova   +5 more
doaj   +1 more source

The gut metabolite indole-3-propionic acid activates ERK1 to restore social function and hippocampal inhibitory synaptic transmission in a 16p11.2 microdeletion mouse model. [PDF]

Microbiome
Background Microdeletion of the human chromosomal region 16p11.2 (16p11.2 $${}^{+/-}$$ + / - ) is a prevalent genetic factor associated with autism spectrum disorder (ASD) and other neurodevelopmental disorders.
Jiang J, Wang D, Jiang Y, Yang X, Sun R, Chang J, Zhu W, Yao P, Song K, Chang S, Wang H, Zhou L, Zhang XS, Li H, Li N.   +14 more
europepmc   +2 more sources

Gut microbiota-derived indole-3-propionic acid alleviates diabetic kidney disease through its mitochondrial protective effect via reducing ubiquitination mediated-degradation of SIRT1. [PDF]

J Adv Res
Graphical abstract The proposed model for the beneficial effects of indole-3-propionic acid (IPA) on diabetic kidney disease (DKD) involves the mitigation of mitochondrial dysfunction in glomerular endothelial cells (GECs) through the following mechanism:
Zeng Y, Guo M, Wu Q, Tan X, Jiang C, Teng F, Chen J, Zhang F, Ma X, Li X, Gu J, Huang W, Zhang C, Yuen-Kwan Law B, Long Y, Xu Y.   +15 more
europepmc   +2 more sources

Evaluation of Sample Recovery of Odorous VOCs and Semi‐VOCs From Odor Bags, Sampling Canisters, Tenax TA Sorbent Tubes, and SPME [PDF]

, 2009
Odor samples collected in field research are complex mixtures of hundreds if not thousands of compounds. Research is needed to know how best to sample and analyze these compounds.
Koziel, Jacek, Koziel, Jacek, Kuhrt, Fred, Lloyd, Jenny, Parker, David, Spinhirne, Jarett, Wright, Donald   +6 more
core   +3 more sources