Results 21 to 30 of about 44,829 (223)

Indoleamine 2,3‐dioxygenase 1 (IDO1): an up‐to‐date overview of an eclectic immunoregulatory enzyme

The FEBS Journal, 2021
Indoleamine 2,3‐dioxygenase 1 (IDO1) catalyzes the initial rate‐limiting step in the degradation of the essential amino acid tryptophan along the kynurenine pathway.
M. T. Pallotta, S. Rossini, C. Suvieri, Alice Coletti, C. Orabona, A. Macchiarulo, C. Volpi, U. Grohmann   +7 more
semanticscholar   +1 more source

From Melanoma Development to RNA-Modified Dendritic Cell Vaccines: Highlighting the Lessons From the Past

Frontiers in Immunology, 2021
Although melanoma remains the deadliest skin cancer, the current treatment has not resulted in the desired outcomes. Unlike chemotherapy, immunotherapy has provided more tolerable approaches and revolutionized cancer therapy.
Mahdi Abdoli Shadbad, Mahdi Abdoli Shadbad, Khalil Hajiasgharzadeh, Afshin Derakhshani, Afshin Derakhshani, Nicola Silvestris, Nicola Silvestris, Amir Baghbanzadeh, Vito Racanelli, Behzad Baradaran, Behzad Baradaran   +10 more
doaj   +1 more source

RETRACTED ARTICLE: Kynurenine promotes neonatal heart regeneration by stimulating cardiomyocyte proliferation and cardiac angiogenesis

Nature Communications, 2022
Indoleamine 2,3 dioxygenase-1 (IDO1) catalyzes tryptophan-kynurenine metabolism in many inflammatory and cancer diseases. Of note, acute inflammation that occurs immediately after heart injury is essential for neonatal cardiomyocyte proliferation and ...
Donghong Zhang, Jinfeng Ning, Tharmarajan Ramprasath, Changjiang Yu, Xiaoxu Zheng, Ping Song, Zhonglin Xie, Ming-Hui Zou   +7 more
doaj   +1 more source

Increased Indoleamine 2,3-Dioxygenase 1 (IDO-1) Activity and Inflammatory Responses during Chikungunya Virus Infection

Pathogens, 2022
Chikungunya virus (CHIKV) infection causes intense cytokine/chemokine inflammatory responses and debilitating joint pain. Indoleamine2,3–dioxygenase 1 (IDO-1) is an enzyme that initiates the tryptophan degradation that is important in initial host innate
Thiara Manuele Alves de Souza, Caroline Fernandes-Santos, Jéssica Araújo da Paixão de Oliveira, Larissa Cristina Teixeira Tomé, Victor Edgar Fiestas-Solórzano, Priscila Conrado Guerra Nunes, Gabriel Macedo Costa Guimaraes, Juan Camilo Sánchez-Arcila, Iury Amâncio Paiva, Luís Jose de Souza, Paulo Vieira Damasco, Válber da Silva Frutuoso, Manoela Heringer, Luzia Maria de Oliveira-Pinto, Roberta Olmo Pinheiro, Flavia Barreto dos Santos, Elzinandes Leal de Azeredo   +16 more
doaj   +1 more source

Novel Selective IDO1 Inhibitors with Isoxazolo[5,4-d]pyrimidin-4(5H)-one Scaffold

Pharmaceuticals, 2021
Indoleamine 2,3-dioxygenase 1 (IDO1) is a promising target in immunomodulation of several pathological conditions, especially cancers. Here we present the synthesis of a series of IDO1 inhibitors with the novel isoxazolo[5,4-d]pyrimidin-4(5H)-one ...
Ana Dolšak, Tomaž Bratkovič, Larisa Mlinarič, Eva Ogorevc, Urban Švajger, Stanislav Gobec, Matej Sova   +6 more
doaj   +1 more source

Indoleamine 2,3-Dioxygenase 1 Deletion–Mediated Kynurenine Insufficiency in Vascular Smooth Muscle Cells Exacerbates Arterial Calcification

Circulation, 2022
Background: IDO1 (indoleamine 2,3-dioxygenase 1) is the rate-limiting enzyme for tryptophan metabolism. IDO1 malfunction is involved in the pathogenesis of atherosclerosis.
Ouyang Liu, Changjiang Yu, Zhiyong Xie, Xiaoyan Su, Zengmei Xu, P. Song, Jian Li, Hui Huang, Ye Ding, M. Zou   +9 more
semanticscholar   +1 more source

Research progress of indoleamine 2,3-dioxygenase 1 in gastric cancer

生物医学转化, 2023
Gastric cancer is the fifth most common malignant tumor and fourth leading cause of cancerrelated deaths worldwide. Gastric cancer has obvious heterogeneity and complex tumor microenvironment. Although immune checkpoint inhibitors have shown certain anti-
Pei Xiaxia, Zhao Jun, Tian Kun, Luo Yaoting, Qi Yali, Wang Zhiping, Song Feixue   +6 more
doaj   +1 more source

The Role of Indoleamine 2, 3-Dioxygenase 1 in Regulating Tumor Microenvironment

Cancers, 2022
Simple Summary Tumor microenvironment is a complex and dynamically changing entity, which is crucial for tumor development. Indoleamine 2, 3-dioxygenase 1 is elevated in the tumor microenvironment and is strongly associated with tumor histological ...
Xinting Huang, Feng Zhang, Xiaobo Wang, Li-Yu Daisy Liu   +3 more
semanticscholar   +1 more source

Dexamethasone Induces the Expression and Function of Tryptophan-2-3-Dioxygenase in SK-MEL-28 Melanoma Cells

Pharmaceuticals, 2021
Tryptophan-2,3-dioxygenase (TDO) is one of the key tryptophan-catabolizing enzymes with immunoregulatory properties in cancer. Contrary to expectation, clinical trials showed that inhibitors of the ubiquitously expressed enzyme, indoleamine-2,3 ...
Marta Cecchi, Sara Paccosi, Angela Silvano, Ali Hussein Eid, Astrid Parenti   +4 more
doaj   +1 more source

High INDO (indoleamine 2,3-dioxygenase) mRNA level in blasts of acute myeloid leukemic patients predicts poor clinical outcome [PDF]

, 2008
Indoleamine 2,3-dioxygenase degrades the amino acid tryptophan which is essential for T cells. Tryptophan depletion causes T-cell cycle arrest and solid tumors that express high levels of indoleamine 2,3-dioxygenase can create immune suppression ...
Chamuleau, M.E.D. (Martine), Delwel, H.R. (Ruud), Hess, C.J. (Corine), Janssen, J.J.W.M. (Jeroen), Loosdrecht, A.A. (Arjan) van de, Löwenberg, B. (Bob), Ossenkoppele, G.J. (Gert), Valk, P.J.M. (Peter), Zevenbergen, A. (Adri)   +8 more
core   +5 more sources