Results 51 to 60 of about 44,829 (223)
ACS Medicinal Chemistry Letters, 2017 A data-centric medicinal chemistry approach led to the invention of a potent and selective IDO1 inhibitor 4f, INCB24360 (epacadostat). The molecular structure of INCB24360 contains several previously unknown or underutilized functional groups in drug ...
E. Yue +25 more
semanticscholar +1 more source
Indoleamine, 2-3 dioxygenase activity could be an early marker of graft rejection in heart transplantation [PDF]
, 2012 [Abstract] Background. The indoleamine, 2-3 dioxygenase (IDO) is an inducible intracellular enzyme with immunosuppressive effects mainly on lymphocyte populations.
Barge-Caballero, Eduardo +9 more
core +3 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 The kynurenine pathway is the major tryptophan degradation routes generating bioactive compounds important in physiology and diseases. Depending on cell type it is initiated enzymatically by tryptophan-2,3-dioxygenase (TDO) or indoleamine-2,3-dioxygenase
Ilona Sadok +3 more
doaj +1 more source
Association of Systemic Inflammation With Retinal Vascular Caliber in Patients With AIDS. [PDF]
, 2019 PurposeTo evaluate relationships among retinal vascular caliber and biomarkers of systemic inflammation in patients with AIDS.MethodsA total of 454 participants with AIDS had retinal vascular caliber (central retinal artery equivalent and central retinal
Cheu, Ryan +9 more
core +1 more source
ACS Medicinal Chemistry Letters, 2020 Indoleamine-2,3-dioxygenase 1 (IDO1) inhibition and its combination with immune checkpoint inhibitors like pembrolizumab have drawn considerable attention from both academia and the pharmaceutical industry.
Q. Pu +22 more
semanticscholar +1 more source
Indoleamine 2,3-Dioxygenase as a Therapeutic Target for Alzheimer’s Disease and Geriatric Depression
Brain Sciences, 2023 Neuroimmune-triggered neuroinflammation of the central nervous system is emerging as an important aetiopathogenic factor for multiple neurological disorders, including depression, dementia, Alzheimer’s disease, multiple sclerosis and others.
Karl Savonije +2 more
doaj +1 more source
Enhanced Immunomodulation in Inflammatory Environments Favors Human Cardiac Mesenchymal Stromal-Like Cells for Allogeneic Cell Therapies [PDF]
, 2019 Rising numbers of patients with cardiovascular diseases and limited availability of donor hearts require new and improved therapy strategies. Human atrial appendage-derived cells (hAACs) are promising candidates for an allogeneic cell-based treatment. In
Diedrichs, Falk +5 more
core +1 more source
Inhibition Mechanisms of Indoleamine 2,3-Dioxygenase 1 (IDO1).
Journal of Medicinal Chemistry, 2019 Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the rate-limiting step in the kynurenine pathway of tryptophan metabolism, which is involved in immunity, neuronal function, and aging.
U. Röhrig +5 more
semanticscholar +1 more source
Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors
Molecules, 2019 IDO1, a key dioxygenase in tryptophan-kynurenine metabolism, appeared in the last 10 years at the vanguard of druggable targets in cancer therapy due to its well-established role both in immune escape and inflammatory neovascularization.
Marta Serafini +5 more
doaj +1 more source
Molecular Cancer Therapeutics, 2018 Tumors use indoleamine 2,3-dioxygenase-1 (IDO1) as a major mechanism to induce an immunosuppressive microenvironment. IDO1 expression is upregulated in many cancers and considered to be a resistance mechanism to immune checkpoint therapies.
B. Gomes +27 more
semanticscholar +1 more source