Results 1 to 10 of about 197,632 (380)
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. [PDF]
, 2010 Francisella tularensis, the causative agent of tularemia, infects host macrophages, which triggers production of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-18. We elucidate here how host macrophages recognize F.
Alnemri, Emad S +12 more
core +5 more sources
Gout-associated uric acid crystals activate the NALP3 inflammasome [PDF]
Nature, 2006 Fabio Martinon +4 more
openalex +2 more sources
Interplay Between NLRP3 Inflammasome and Autophagy
Frontiers in Immunology, 2020 The NLRP3 inflammasome is cytosolic multi-protein complex that induces inflammation and pyroptotic cell death in response to both pathogen (PAMPs) and endogenous activators (DAMPs).
Monika Biasizzo +2 more
doaj +2 more sources
Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection
Frontiers in Cell and Developmental Biology, 2021 Bacterial infection tendentiously triggers inflammasome activation, whereas the roles of inflammasome activation in host defense against diverse infections remain unclear.
Yu Guo +11 more
doaj +1 more source
The NLRP3 inflammasome: contributions to inflammation-related diseases
Cellular & Molecular Biology Letters, 2023 The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory cytokines interleukin (IL)-1β and IL-18.
Ying Chen +11 more
semanticscholar +1 more source
The role of NLRP3 inflammasome in the pathogenesis of rheumatic disease
Autoimmunity, 2022 Inflammasome is a molecular platform that is formed in the cytosolic compartment to mediate host immune responses to infection and cellular damage. Inflammasome can activate caspase-1, leading to the maturation of two inflammatory cytokines interleukin ...
Ruixue Kong +3 more
doaj +1 more source
Neutrophils Facilitate Prolonged Inflammasome Response in the DAMP-Rich Inflammatory Milieu
Frontiers in Immunology, 2021 Aberrant inflammasome activation contributes to various chronic inflammatory diseases; however, pyroptosis of inflammasome-active cells promptly terminates local inflammasome response. Molecular mechanisms underlying prolonged inflammasome signaling thus
Seunghwan Son +7 more
doaj +1 more source
Science immunology, 2023 NLRP3 inflammasome activation is a highly regulated process for controlling secretion of the potent inflammatory cytokines IL-1β and IL-18 that are essential during bacterial infection, sterile inflammation, and disease, including colitis, diabetes ...
Sung Hoon Baik +5 more
semanticscholar +1 more source
Inhibition of NLRP3 Inflammasome: A Prospective Target for the Treatment of Ischemic Stroke
Frontiers in Cellular Neuroscience, 2020 Stroke is one of the major devastating diseases with no effective medical therapeutics. Because of the high rate of disability and mortality among stroke patients, new treatments are urgently required to decrease brain damage following a stroke.
Ya-Shuo Feng +6 more
doaj +1 more source
Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation.
Annual Review of Immunology, 2022 As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic invasions and endogenous cellular damage and responds by forming the NLRP3 inflammasome, a supramolecular complex that activates caspase-1.
Jianing Fu, Hao Wu
semanticscholar +1 more source