Results 1 to 10 of about 6,721 (55)
Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection
Frontiers in Cell and Developmental Biology, 2021 Bacterial infection tendentiously triggers inflammasome activation, whereas the roles of inflammasome activation in host defense against diverse infections remain unclear.
Yu Guo +11 more
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The role of NLRP3 inflammasome in the pathogenesis of rheumatic disease
Autoimmunity, 2022 Inflammasome is a molecular platform that is formed in the cytosolic compartment to mediate host immune responses to infection and cellular damage. Inflammasome can activate caspase-1, leading to the maturation of two inflammatory cytokines interleukin ...
Ruixue Kong +3 more
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NLRP3 monomer Functional Dynamics: from the Effects of Allosteric Binding to Implications for Drug Design [PDF]
International Journal of Biological Macromolecules 246 (2023)
125609, 2023 The protein NLRP3 and its complexes are associated with an array of inflammatory pathologies, among which neurodegenerative, autoimmune, and metabolic diseases. Targeting the NLRP3 inflammasome represents a promising strategy for easing the symptoms of pathologic neuroinflammation.
arxiv +1 more source
Inhibition of NLRP3 Inflammasome: A Prospective Target for the Treatment of Ischemic Stroke
Frontiers in Cellular Neuroscience, 2020 Stroke is one of the major devastating diseases with no effective medical therapeutics. Because of the high rate of disability and mortality among stroke patients, new treatments are urgently required to decrease brain damage following a stroke.
Ya-Shuo Feng +6 more
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Neutrophils Facilitate Prolonged Inflammasome Response in the DAMP-Rich Inflammatory Milieu
Frontiers in Immunology, 2021 Aberrant inflammasome activation contributes to various chronic inflammatory diseases; however, pyroptosis of inflammasome-active cells promptly terminates local inflammasome response. Molecular mechanisms underlying prolonged inflammasome signaling thus
Seunghwan Son +7 more
doaj +1 more source
Journal of Translational Medicine, 2023 Background Complement component 3a and its receptor (C3a/C3aR) and the nucleotide-binding oligomerization domain-like receptor protein-3 (NLRP3) inflammasome contribute to epithelial-mesenchymal transition (EMT).
Danyu You +7 more
doaj +1 more source
Kynurenic acid ameliorates NLRP3 inflammasome activation by blocking calcium mobilization via GPR35
Frontiers in Immunology, 2022 The inflammasome has been linked to diverse inflammatory and metabolic diseases, and tight control of inflammasome activation is necessary to avoid excessive inflammation. Kynurenic acid (KA) is a tryptophan metabolite in the kynurenine pathway. However,
Tianyin Sun +10 more
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NLRP3 Sensing of Diverse Inflammatory Stimuli Requires Distinct Structural Features
Frontiers in Immunology, 2020 The NLRP3 inflammasome is central to host defense and implicated in various inflammatory diseases and conditions. While the favored paradigm of NLRP3 inflammasome activation stipulates a unifying signal intermediate that de-represses NLRP3, this view has
Tabassum Rahman +5 more
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eLife, 2022 Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory syndrome caused by mutations of NLRP3 gene encoding cryopyrin. Familial cold autoinflammatory syndrome, the mildest form of CAPS, is characterized by cold-induced inflammation induced ...
Tadayoshi Karasawa +8 more
doaj +1 more source
Animals, 2020 Inflammation is critical for infection control and acts as an arsenal defense mechanism against invading microbes through activation of the host immune system.
Amin Tahoun +7 more
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