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Journal of Experimental Medicine, 2018 In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation. Surprisingly, they find that caspase-1 is quickly inactivated upon autoproteolytic processing.
Sandstrom, Andrew, Vance, Russell E
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Inflammasomes and Fibrosis [PDF]
Frontiers in Immunology, 2021 Fibrosis is the final common pathway of inflammatory diseases in various organs. The inflammasomes play an important role in the progression of fibrosis as innate immune receptors.
Wen-Juan Zhang +5 more
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Molecular Aspects of Medicine, 2020 Ketelut-Carneiro and Fitzgerald discuss the basic concepts about inflammasome composition, assembly and activation, effector functions and role in infection and inflammatory disease.
Natália, Ketelut-Carneiro +1 more
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Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection
Frontiers in Cell and Developmental Biology, 2021 Bacterial infection tendentiously triggers inflammasome activation, whereas the roles of inflammasome activation in host defense against diverse infections remain unclear.
Yu Guo +11 more
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Cold Spring Harbor Perspectives in Biology, 2014 Inflammasomes are large cytosolic multiprotein complexes that assemble in response to detection of infection- or stress-associated stimuli and lead to the activation of caspase-1-mediated inflammatory responses, including cleavage and unconventional secretion of the leaderless proinflammatory cytokines IL-1β and IL-18, and initiation of an inflammatory
de Zoete, Marcel R +3 more
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Molecules, 2021 In recent years, the interplay between the activation of the immune system, the development of chronic inflammation and the onset and progression of many different diseases has been studied extensively [...]
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The role of NLRP3 inflammasome in the pathogenesis of rheumatic disease
Autoimmunity, 2022 Inflammasome is a molecular platform that is formed in the cytosolic compartment to mediate host immune responses to infection and cellular damage. Inflammasome can activate caspase-1, leading to the maturation of two inflammatory cytokines interleukin ...
Ruixue Kong +3 more
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Immunology, 2021 SummaryInflammasomes are generally thought of as large protein complexes that assemble in the cytosol in response to danger such as tissue damage or infection; once activated, they trigger production of inflammatory cytokines and drive cells towards a pro‐inflammatory death – termed pyroptosis.
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Neutrophils Facilitate Prolonged Inflammasome Response in the DAMP-Rich Inflammatory Milieu
Frontiers in Immunology, 2021 Aberrant inflammasome activation contributes to various chronic inflammatory diseases; however, pyroptosis of inflammasome-active cells promptly terminates local inflammasome response. Molecular mechanisms underlying prolonged inflammasome signaling thus
Seunghwan Son +7 more
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Inhibition of NLRP3 Inflammasome: A Prospective Target for the Treatment of Ischemic Stroke
Frontiers in Cellular Neuroscience, 2020 Stroke is one of the major devastating diseases with no effective medical therapeutics. Because of the high rate of disability and mortality among stroke patients, new treatments are urgently required to decrease brain damage following a stroke.
Ya-Shuo Feng +6 more
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