Gout-associated uric acid crystals activate the NALP3 inflammasome [PDF]
Nature, 2006 Fabio Martinon +4 more
openalex +2 more sources
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome [PDF]
Nature Immunology, 2010 Autophagy, a cellular process for organelle and protein turnover, regulates innate immune responses. Here we demonstrate that depletion of the autophagic proteins LC3B and beclin 1 enhanced the activation of caspase-1 and secretion of interleukin 1β (IL ...
Kiichi Nakahira +12 more
openalex +2 more sources
The NLRP3 inflammasome: contributions to inflammation-related diseases
Cellular & Molecular Biology Letters, 2023 The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory cytokines interleukin (IL)-1β and IL-18.
Ying Chen +11 more
semanticscholar +1 more source
Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation.
Annual Review of Immunology, 2022 As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic invasions and endogenous cellular damage and responds by forming the NLRP3 inflammasome, a supramolecular complex that activates caspase-1.
Jianing Fu, Hao Wu
semanticscholar +1 more source
Frontiers in Aging Neuroscience, 2022 The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating the innate immune system and inflammatory signaling. Upon activation by PAMPs and DAMPs, NLRP3 oligomerizes and activates caspase-1 which initiates the processing ...
Hallie Blevins +3 more
semanticscholar +1 more source
An update on the regulatory mechanisms of NLRP3 inflammasome activation
Cellular & Molecular Immunology, 2021 The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is a multiprotein complex involved in the release of mature interleukin-1β and triggering of pyroptosis, which is of paramount importance in a variety of physiological and ...
Seungwha Paik +4 more
semanticscholar +1 more source
The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
International Journal of Molecular Sciences, 2019 The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in response to microbial infection and cellular damage.
N. Kelley +3 more
semanticscholar +1 more source
SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation
Nature Communications, 2021 Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 infection are also associated with COVID-19 severity. Here, we show a distinct mechanism
Pan Pan +21 more
semanticscholar +1 more source
Inflammasome activation in infected macrophages drives COVID-19 pathology
Nature, 2021 Severe COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine production, viral RNA and a sustained interferon (IFN) response, all of which are recapitulated and required for pathology in the SARS-CoV-2-infected MISTRG6-hACE2 ...
Esen Sefik +20 more
semanticscholar +1 more source
Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation
Nature Immunology, 2022 The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and its dysregulation underlies many chronic diseases. Mitochondria have been implicated as regulators of the NLRP3 inflammasome through several mechanisms including ...
L. Billingham +11 more
semanticscholar +1 more source