Results 11 to 20 of about 188,554 (379)
Inflammasomes and Fibrosis [PDF]
Frontiers in Immunology, 2021 Fibrosis is the final common pathway of inflammatory diseases in various organs. The inflammasomes play an important role in the progression of fibrosis as innate immune receptors. There are four main members of the inflammasomes, such as NOD-like receptor protein 1 (NLRP1), NOD-like receptor protein 3 (NLRP3), NOD-like receptor C4 (NLRC4), and absent ...
Wen-Juan Zhang +5 more
openaire +5 more sources
Interplay Between NLRP3 Inflammasome and Autophagy
Frontiers in Immunology, 2020 The NLRP3 inflammasome is cytosolic multi-protein complex that induces inflammation and pyroptotic cell death in response to both pathogen (PAMPs) and endogenous activators (DAMPs).
Monika Biasizzo, N. Kopitar-Jerala
semanticscholar +3 more sources
Molecular Aspects of Medicine, 2020 Ketelut-Carneiro and Fitzgerald discuss the basic concepts about inflammasome composition, assembly and activation, effector functions and role in infection and inflammatory disease.
Natália, Ketelut-Carneiro +1 more
openaire +4 more sources
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis [PDF]
, 2010 Francisella tularensis, the causative agent of tularemia, infects host macrophages, which triggers production of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-18. We elucidate here how host macrophages recognize F.
Teresa Fernandes‐Alnemri +12 more
core +12 more sources
Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection
Frontiers in Cell and Developmental Biology, 2021 Bacterial infection tendentiously triggers inflammasome activation, whereas the roles of inflammasome activation in host defense against diverse infections remain unclear.
Yu Guo +11 more
doaj +1 more source
Cell, 2010 Inflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as interleukin-1beta to engage innate immune defenses. Strong associations between dysregulated inflammasome activity and human heritable and acquired inflammatory diseases highlight the importance this pathway
Schroder, Kate, Tschopp, Jurg
openaire +3 more sources
The role of NLRP3 inflammasome in the pathogenesis of rheumatic disease
Autoimmunity, 2022 Inflammasome is a molecular platform that is formed in the cytosolic compartment to mediate host immune responses to infection and cellular damage. Inflammasome can activate caspase-1, leading to the maturation of two inflammatory cytokines interleukin ...
Ruixue Kong +3 more
doaj +1 more source
Neutrophils Facilitate Prolonged Inflammasome Response in the DAMP-Rich Inflammatory Milieu
Frontiers in Immunology, 2021 Aberrant inflammasome activation contributes to various chronic inflammatory diseases; however, pyroptosis of inflammasome-active cells promptly terminates local inflammasome response. Molecular mechanisms underlying prolonged inflammasome signaling thus
Seunghwan Son +7 more
doaj +1 more source
Cold Spring Harbor Perspectives in Biology, 2014 Inflammasomes are large cytosolic multiprotein complexes that assemble in response to detection of infection- or stress-associated stimuli and lead to the activation of caspase-1-mediated inflammatory responses, including cleavage and unconventional secretion of the leaderless proinflammatory cytokines IL-1β and IL-18, and initiation of an inflammatory
de Zoete, Marcel R +3 more
openaire +3 more sources
Molecules, 2021 In recent years, the interplay between the activation of the immune system, the development of chronic inflammation and the onset and progression of many different diseases has been studied extensively [...]
openaire +4 more sources