Results 21 to 30 of about 188,554 (379)

The NLRP6 inflammasome [PDF]

Immunology, 2020
SummaryThe NOD‐like receptor family pyrin domain containing 6 (NLRP6), a member of the NOD‐like receptor (NLR) family, acts as a cytosolic innate immune sensor that recognizes microbe‐associated molecular patterns. In some circumstances upon activation, NLRP6 recruits the adaptor apoptosis‐associated speck‐like protein (ASC) and the inflammatory ...
Lara Kern, Danping Zheng, Danping Zheng, Eran Elinav   +3 more
openaire   +3 more sources

Inhibition of NLRP3 Inflammasome: A Prospective Target for the Treatment of Ischemic Stroke

Frontiers in Cellular Neuroscience, 2020
Stroke is one of the major devastating diseases with no effective medical therapeutics. Because of the high rate of disability and mortality among stroke patients, new treatments are urgently required to decrease brain damage following a stroke.
Ya-Shuo Feng, Zi-Xuan Tan, Man-Man Wang, Ying Xing, Fang Dong, Feng Zhang, Feng Zhang   +6 more
doaj   +1 more source

Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome

eLife, 2022
Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory syndrome caused by mutations of NLRP3 gene encoding cryopyrin. Familial cold autoinflammatory syndrome, the mildest form of CAPS, is characterized by cold-induced inflammation induced ...
Tadayoshi Karasawa, Takanori Komada, Naoya Yamada, Emi Aizawa, Yoshiko Mizushina, Sachiko Watanabe, Chintogtokh Baatarjav, Takayoshi Matsumura, Masafumi Takahashi   +8 more
doaj   +1 more source

Inflammasomes and dermatology [PDF]

Anais Brasileiros de Dermatologia, 2016
Inflammasomes are intracellular multiprotein complexes that comprise part of the innate immune response. Since their definition, inflammasome disorders have been linked to an increasing number of diseases. Autoinflammatory diseases refer to disorders in which local factors lead to the activation of innate immune cells, causing tissue damage when in the
Sá, Daniel Coelho de, Festa Neto, Cyro
openaire   +5 more sources

Of inflammasomes and pathogens – sensing of microbes by the inflammasome [PDF]

EMBO Molecular Medicine, 2013
Inflammasomes are signalling platforms that sense a diverse range of microbial products and also a number of stress and damage associated endogenous signals. Inflammasome complexes can be formed by members of the Nod-like receptor family or the PYHIN family member AIM2.
Franz Bauernfeind, Veit Hornung
openaire   +3 more sources

C3a/C3aR synergies with TGF-β to promote epithelial-mesenchymal transition of renal tubular epithelial cells via the activation of the NLRP3 inflammasome

Journal of Translational Medicine, 2023
Background Complement component 3a and its receptor (C3a/C3aR) and the nucleotide-binding oligomerization domain-like receptor protein-3 (NLRP3) inflammasome contribute to epithelial-mesenchymal transition (EMT).
Danyu You, Kun Nie, Xiaoting Wu, Mengjie Weng, Liyan Yang, Yi Chen, Jiong Cui, Jianxin Wan   +7 more
doaj   +1 more source

Kynurenic acid ameliorates NLRP3 inflammasome activation by blocking calcium mobilization via GPR35

Frontiers in Immunology, 2022
The inflammasome has been linked to diverse inflammatory and metabolic diseases, and tight control of inflammasome activation is necessary to avoid excessive inflammation. Kynurenic acid (KA) is a tryptophan metabolite in the kynurenine pathway. However,
Tianyin Sun, Ruiqian Xie, Hongbin He, Qianqian Xie, Xueqin Zhao, Guijie Kang, Chen Cheng, Wenwei Yin, Jingjing Cong, Jing Li, Xuefu Wang   +10 more
doaj   +1 more source

Inflammasomes, the eye and anti-inflammasome therapy [PDF]

Eye, 2017
Inflammasomes, key molecular regulators that play an important role in inflammation, consist of a central protein, an adaptor protein ASC (apoptosis speck-like protein) and a caspase-1 protein. Upon activation, caspase-1 induces maturation of cytokines such as interleukin-1β (IL-1β) and interleukin-18 (IL-18).
Yerramothu, P, Vijay, AK, Willcox, MDP
openaire   +4 more sources

Inflammasomes and autoimmunity [PDF]

Trends in Molecular Medicine, 2011
The NOD-like receptor (NLR) family members are cytosolic sensors of microbial components and danger signals. A subset of NLRs control inflammasome assembly that results in caspase-1 activation and, in turn, IL-1β and IL-18 production. Excessive inflammasome activation can cause autoinflammatory disorders, including the hereditary periodic fevers ...
Thirumala-Devi Kanneganti, Michael F. McDermott, Patrick J. Shaw   +2 more
openaire   +3 more sources

TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia

Cell Death and Disease, 2021
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease in the central nervous system (CNS). The NLRP3 inflammasome is considered an important regulator of immunity and inflammation, both of which play a critical role in MS.
Yahui Zhang, Baohua Hou, Peiyu Liang, Xin Lu, Yifan Wu, Xinyi Zhang, Yuanteng Fan, Yumin Liu, Taoxiang Chen, Wanhong Liu, Biwen Peng, Jun Yin, Song Han, Xiaohua He   +13 more
doaj   +1 more source