Results 21 to 30 of about 197,632 (380)
Of inflammasomes and pathogens – sensing of microbes by the inflammasome [PDF]
EMBO Molecular Medicine, 2013 Inflammasomes are signalling platforms that sense a diverse range of microbial products and also a number of stress and damage associated endogenous signals. Inflammasome complexes can be formed by members of the Nod-like receptor family or the PYHIN family member AIM2.
Franz Bauernfeind, Veit Hornung
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Journal of Translational Medicine, 2023 Background Complement component 3a and its receptor (C3a/C3aR) and the nucleotide-binding oligomerization domain-like receptor protein-3 (NLRP3) inflammasome contribute to epithelial-mesenchymal transition (EMT).
Danyu You +7 more
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Kynurenic acid ameliorates NLRP3 inflammasome activation by blocking calcium mobilization via GPR35
Frontiers in Immunology, 2022 The inflammasome has been linked to diverse inflammatory and metabolic diseases, and tight control of inflammasome activation is necessary to avoid excessive inflammation. Kynurenic acid (KA) is a tryptophan metabolite in the kynurenine pathway. However,
Tianyin Sun +10 more
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Frontiers in Aging Neuroscience, 2022 The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating the innate immune system and inflammatory signaling. Upon activation by PAMPs and DAMPs, NLRP3 oligomerizes and activates caspase-1 which initiates the processing ...
Hallie Blevins +3 more
semanticscholar +1 more source
Inflammasomes, the eye and anti-inflammasome therapy [PDF]
Eye, 2017 Inflammasomes, key molecular regulators that play an important role in inflammation, consist of a central protein, an adaptor protein ASC (apoptosis speck-like protein) and a caspase-1 protein. Upon activation, caspase-1 induces maturation of cytokines such as interleukin-1β (IL-1β) and interleukin-18 (IL-18).
Yerramothu, P, Vijay, AK, Willcox, MDP
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A novel mechanism for NLRP3 inflammasome activation
Metabolism Open, 2022 The NLRP3 inflammasome, as an important component of the innate immune system, plays vital roles in various metabolic disorders. It has been reported that the NLRP3 inflammasome can be activated by a broad range of distinct stimuli, such as K+ efflux ...
Tan Zhang +6 more
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Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation
Nature Immunology, 2022 The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and its dysregulation underlies many chronic diseases. Mitochondria have been implicated as regulators of the NLRP3 inflammasome through several mechanisms including ...
L. Billingham +11 more
semanticscholar +1 more source
Inflammasomes and autoimmunity [PDF]
Trends in Molecular Medicine, 2011 The NOD-like receptor (NLR) family members are cytosolic sensors of microbial components and danger signals. A subset of NLRs control inflammasome assembly that results in caspase-1 activation and, in turn, IL-1β and IL-18 production. Excessive inflammasome activation can cause autoinflammatory disorders, including the hereditary periodic fevers ...
Thirumala-Devi Kanneganti +2 more
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NLRP3 Sensing of Diverse Inflammatory Stimuli Requires Distinct Structural Features
Frontiers in Immunology, 2020 The NLRP3 inflammasome is central to host defense and implicated in various inflammatory diseases and conditions. While the favored paradigm of NLRP3 inflammasome activation stipulates a unifying signal intermediate that de-represses NLRP3, this view has
Tabassum Rahman +5 more
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TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia
Cell Death and Disease, 2021 Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease in the central nervous system (CNS). The NLRP3 inflammasome is considered an important regulator of immunity and inflammation, both of which play a critical role in MS.
Yahui Zhang +13 more
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