Results 31 to 40 of about 6,721 (55)
Nanoreporter for Real‐Time Monitoring of Inflammasome Activity and Targeted Therapy
Advanced Science, 2023 Inflammasome activation is associated with a myriad of inflammatory diseases. However, existing methods provides a limited understanding of spatiotemporal kinetics of inflammasome activation, with restricted scope for early detection of associated ...
Dipika Nandi +5 more
doaj +1 more source
A single-cell mathematical model of SARS-CoV-2 induced pyroptosis and the effects of anti-inflammatory intervention [PDF]
arXiv, 2020 Pyroptosis is an inflammatory mode of cell death that can contribute to the cytokine storm associated with severe cases of coronavirus disease 2019 (COVID-19). The formation of the NLRP3 inflammasome is central to pyroptosis, which may be induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
arxiv
Tivantinib alleviates inflammatory diseases by directly targeting NLRP3
iScience, 2023 Summary: NLRP3 inflammasome-mediated immune responses are involved in the pathogenesis of multiple inflammatory diseases, but few clinical drugs are identified that directly target the NLRP3 inflammasome to treat these diseases to date.
Yi Huang +6 more
doaj
Pyroptosis: Physiological roles in viral infection [PDF]
arXiv, 2020 The current review focuses on important aspects of pyroptosis, such as morphological features of inflammasomes, as well as on knowledge about coronavirus infection mechanisms and the association between SARS-CoV-2 infection and cell pyroptosis. The application of immunomodulation therapies to Covid-19 patients is the most promising treatment under ...
arxiv
Clinical and Translational Medicine, 2020 Inflammation is an important process involved in several cardiovascular diseases (CVDs), and nod‐like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a vital player in innate immunity and inflammation.
Yucheng Wang +6 more
doaj +1 more source
Frontiers in Immunology, 2023 The NLRP3 inflammasome plays a critical role in the innate immune response, and its excessive activation will cause pyroptotic cell death and be associated with the onset of inflammatory diseases. However, NLRP3 inflammasome targeting therapies are still
Qianqian Di +8 more
doaj +1 more source
Predicting COVID-19 distribution in Mexico through a discrete and time-dependent Markov chain and an SIR-like model [PDF]
arXiv, 2020 COVID-19 is an emergent viral infection which rose in December 2019 in a city in the Chinese province of Hubei, Wuhan; the viral aetiology of this infection is now known as COVID-19 virus, which belongs to the Betacoronavirus genus. This virus produces the syndrome of acute respiratory stress that h as been witnessed in other coronaviruses, such as ...
arxiv
A novel mechanism for NLRP3 inflammasome activation
Metabolism Open, 2022 The NLRP3 inflammasome, as an important component of the innate immune system, plays vital roles in various metabolic disorders. It has been reported that the NLRP3 inflammasome can be activated by a broad range of distinct stimuli, such as K+ efflux ...
Tan Zhang +6 more
doaj
JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation
Scientific Reports, 2022 Dysregulation of inflammasome activation induces chronic and excess inflammation resulting in several disorders, such as metabolic disorders and cancers.
Gilyoung Lee +6 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2015 Background: Neuregulin (NRG)-1-human epidermal receptor (HER)-2 signaling pathway is a key regulator of IL-1β-mediated pulmonary inflammation and epithelial permeability.
Rajanbabu Venugopal +7 more
doaj +1 more source