Results 1 to 10 of about 56,139 (234)
Activation of Nlrp3 inflammasomes enhances macrophage lipid-deposition and migration: implication of a novel role of inflammasome in atherogenesis. [PDF]
PLoS ONE, 2014 Although Nlrp3 inflammasome activation in macrophages has been shown to be critical for the development of atherosclerosis upon atherogenic stimuli, it remains unknown whether activated Nlrp3 inflammasomes by other non-atherogenic stimuli induce ...
Xiang Li +5 more
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Role of inflammasomes in Toxoplasma and Plasmodium infections [PDF]
Parasites & VectorsBackground The detection of pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) by multimeric protein complexes, known as inflammasomes, triggers an inflammatory response, which is a critical component of the ...
Zhi-xin Wang +4 more
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Inflammasomes: potential therapeutic targets in hematopoietic stem cell transplantation [PDF]
Cell Communication and SignalingThe realm of hematopoietic stem cell transplantation (HSCT) has witnessed remarkable advancements in elevating the cure and survival rates for patients with both malignant and non-malignant hematologic diseases.
Jieya Luo +4 more
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Inflammasomes in neurodegenerative diseases [PDF]
Translational NeurodegenerationInflammasomes represent a crucial component of the innate immune system, which respond to threats by recognizing different molecules. These are known as pathogen-associated molecular patterns (PAMPs) or host-derived damage-associated molecular patterns ...
Qianchen Wang +7 more
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Roles of inflammasomes in viral myocarditis
Frontiers in Cellular and Infection Microbiology, 2023 Viral myocarditis (VMC), characterized by viral infection-induced inflammation, is a life-threatening disease associated with dilated cardiomyopathy or heart failure.
Jingyu Xu +5 more
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The roles of inflammasomes in cancer
Frontiers in Immunology, 2023 Inflammation is a key characteristic of all stages of tumor development, including tumor initiation, progression, malignant transformation, invasion, and metastasis.
Zihan Deng +5 more
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Emerging Roles of Inflammasomes in Cardiovascular Diseases
Frontiers in Immunology, 2022 Cardiovascular diseases are known as the leading cause of morbidity and mortality worldwide. As an innate immune signaling complex, inflammasomes can be activated by various cardiovascular risk factors and regulate the activation of caspase-1 and the ...
Yingnan Liao, Kui Liu, Liyuan Zhu
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Inflammasomes and Colorectal Cancer
Cells, 2021 Inflammasomes are important intracellular multiprotein signaling complexes that modulate the activation of caspase-1 and induce levels of the proinflammatory cytokines interleukin-1β (IL-1β) and IL-18 in response to pathogenic microorganisms and ...
Sanaz Keshavarz Shahbaz +5 more
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NLRP3 monomer Functional Dynamics: from the Effects of Allosteric Binding to Implications for Drug Design [PDF]
International Journal of Biological Macromolecules 246 (2023)
125609, 2023 The protein NLRP3 and its complexes are associated with an array of inflammatory pathologies, among which neurodegenerative, autoimmune, and metabolic diseases. Targeting the NLRP3 inflammasome represents a promising strategy for easing the symptoms of pathologic neuroinflammation.
arxiv +1 more source
Updating the NLRC4 Inflammasome: from Bacterial Infections to Autoimmunity and Cancer
Frontiers in Immunology, 2021 Inflammasomes comprise a family of cytosolic multi-protein complexes that modulate the activation of cysteine-aspartate-specific protease 1 (caspase-1) and promote the maturation and secretion of interleukin (IL)-1β and IL-18, leading to an inflammatory ...
Jiexia Wen +8 more
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