Results 1 to 10 of about 44,745 (296)

Activation of Nlrp3 inflammasomes enhances macrophage lipid-deposition and migration: implication of a novel role of inflammasome in atherogenesis. [PDF]

PLoS ONE, 2014
Although Nlrp3 inflammasome activation in macrophages has been shown to be critical for the development of atherosclerosis upon atherogenic stimuli, it remains unknown whether activated Nlrp3 inflammasomes by other non-atherogenic stimuli induce ...
Xiang Li, Yang Zhang, Min Xia, Erich Gulbins, Krishna M Boini, Pin-Lan Li   +5 more
doaj   +5 more sources

Antiviral Inflammasomes and How to Find Them [PDF]

Viruses
Inflammasomes are signaling complexes of the innate immune system that are assembled in distinct sentinel cell types to coordinate inflammation. As demonstrated by the emergence of viral antagonists and evasion mechanisms, inflammasomes are critical to ...
Jennifer Deborah Wuerth, Florian Ingo Schmidt   +1 more
doaj   +2 more sources

Targeting inflammasomes as an immunotherapeutic strategy for cancer [PDF]

Journal of Translational Medicine
Inflammasomes are essential regulators of innate immunity, inflammation, and cellular apoptosis, and they have surfaced as significant modulators of cancer progression and regulation.
Luanluan Huang, Xiaoyan Chen, Ruiqi Liu, Ding Nan, Wenxuan Bao, Lixian Yang, Xiaomeng Dai, Jianming Tang, Haibo Zhang, Yanwei Lu   +9 more
doaj   +2 more sources

Inflammasomes and pyroptosis in cancer: mechanisms and therapeutic advances [PDF]

Journal of Hematology & Oncology
Inflammasomes are being increasingly recognized for their critical roles in regulating immune cell infiltration, antitumor immunity, and tumorigenesis in cancer biology.
Wonhyoung Seo, Bokeum Jung, Taylor Roh, Hyo Jung Shin, Ik-Chan Song, Chaeuk Chung, Eun-Kyeong Jo   +6 more
doaj   +2 more sources

Regulation of cancer by inflammasomes: from inflammation to tumorigenesis [PDF]

Frontiers in Immunology
Inflammation is closely linked to the development and progression of cancer, as well as the effectiveness of cancer treatment. Inflammation is an immune response triggered when the immune system detects harmful stimuli such as pathogens, damaged cells ...
Shivani Malvankar, Pundrik Jaiswal, Panchami P. Bhat, Subhash Mehto   +3 more
doaj   +2 more sources

Inflammasomes cross-talk with lymphocytes to connect the innate and adaptive immune response

Journal of Advanced Research, 2023
Background: Innate and adaptive immunity are two different parts of the immune system that have different characteristics and work together to provide immune protection. Inflammasomes are a major part of the innate immune system that are expressed widely
Hongliang Zhang, Jie Gao, Yujie Tang, Tengchuan Jin, Jinhui Tao   +4 more
doaj   +1 more source

Roles of inflammasomes in viral myocarditis

Frontiers in Cellular and Infection Microbiology, 2023
Viral myocarditis (VMC), characterized by viral infection-induced inflammation, is a life-threatening disease associated with dilated cardiomyopathy or heart failure.
Jingyu Xu, Zihao Zhou, Yidan Zheng, Sai Yang, Kun Huang, Huili Li   +5 more
doaj   +1 more source

The roles of inflammasomes in cancer

Frontiers in Immunology, 2023
Inflammation is a key characteristic of all stages of tumor development, including tumor initiation, progression, malignant transformation, invasion, and metastasis.
Zihan Deng, Lisen Lu, Binghui Li, Xiujuan Shi, Honglin Jin, Weidong Hu   +5 more
doaj   +1 more source

Emerging Roles of Inflammasomes in Cardiovascular Diseases

Frontiers in Immunology, 2022
Cardiovascular diseases are known as the leading cause of morbidity and mortality worldwide. As an innate immune signaling complex, inflammasomes can be activated by various cardiovascular risk factors and regulate the activation of caspase-1 and the ...
Yingnan Liao, Kui Liu, Liyuan Zhu
doaj   +1 more source

Inflammasomes and Colorectal Cancer

Cells, 2021
Inflammasomes are important intracellular multiprotein signaling complexes that modulate the activation of caspase-1 and induce levels of the proinflammatory cytokines interleukin-1β (IL-1β) and IL-18 in response to pathogenic microorganisms and ...
Sanaz Keshavarz Shahbaz, Khadijeh Koushki, Seyed Hassan Ayati, Abigail R. Bland, Evgeny E. Bezsonov, Amirhossein Sahebkar   +5 more
doaj   +1 more source