Results 1 to 10 of about 47,495 (266)

Targeting inflammasomes as an immunotherapeutic strategy for cancer [PDF]

Journal of Translational Medicine
Inflammasomes are essential regulators of innate immunity, inflammation, and cellular apoptosis, and they have surfaced as significant modulators of cancer progression and regulation.
Luanluan Huang, Xiaoyan Chen, Ruiqi Liu, Ding Nan, Wenxuan Bao, Lixian Yang, Xiaomeng Dai, Jianming Tang, Haibo Zhang, Yanwei Lu   +9 more
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Inflammasomes and pyroptosis in cancer: mechanisms and therapeutic advances [PDF]

Journal of Hematology & Oncology
Inflammasomes are being increasingly recognized for their critical roles in regulating immune cell infiltration, antitumor immunity, and tumorigenesis in cancer biology.
Wonhyoung Seo, Bokeum Jung, Taylor Roh, Hyo Jung Shin, Ik-Chan Song, Chaeuk Chung, Eun-Kyeong Jo   +6 more
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Inflammasomes: novel therapeutic targets for metabolic syndrome? [PDF]

Frontiers in Endocrinology
Chronic inflammation is a hallmark for Metabolic Syndrome (MetS). It is also one of the most important risk factors for insulin resistance and metabolic disorders.
Pengyu Cao, Pengyu Cao, Yulin Yang, Yulin Yang, Ningning Zhang, Bojian Wang, Zhenwei Gong   +6 more
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Inflammasomes cross-talk with lymphocytes to connect the innate and adaptive immune response

Journal of Advanced Research, 2023
Background: Innate and adaptive immunity are two different parts of the immune system that have different characteristics and work together to provide immune protection. Inflammasomes are a major part of the innate immune system that are expressed widely
Hongliang Zhang, Jie Gao, Yujie Tang, Tengchuan Jin, Jinhui Tao   +4 more
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Roles of inflammasomes in viral myocarditis

Frontiers in Cellular and Infection Microbiology, 2023
Viral myocarditis (VMC), characterized by viral infection-induced inflammation, is a life-threatening disease associated with dilated cardiomyopathy or heart failure.
Jingyu Xu, Zihao Zhou, Yidan Zheng, Sai Yang, Kun Huang, Huili Li   +5 more
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The roles of inflammasomes in cancer

Frontiers in Immunology, 2023
Inflammation is a key characteristic of all stages of tumor development, including tumor initiation, progression, malignant transformation, invasion, and metastasis.
Zihan Deng, Lisen Lu, Binghui Li, Xiujuan Shi, Honglin Jin, Weidong Hu   +5 more
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Emerging Roles of Inflammasomes in Cardiovascular Diseases

Frontiers in Immunology, 2022
Cardiovascular diseases are known as the leading cause of morbidity and mortality worldwide. As an innate immune signaling complex, inflammasomes can be activated by various cardiovascular risk factors and regulate the activation of caspase-1 and the ...
Yingnan Liao, Kui Liu, Liyuan Zhu
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Inflammasomes and Colorectal Cancer

Cells, 2021
Inflammasomes are important intracellular multiprotein signaling complexes that modulate the activation of caspase-1 and induce levels of the proinflammatory cytokines interleukin-1β (IL-1β) and IL-18 in response to pathogenic microorganisms and ...
Sanaz Keshavarz Shahbaz, Khadijeh Koushki, Seyed Hassan Ayati, Abigail R. Bland, Evgeny E. Bezsonov, Amirhossein Sahebkar   +5 more
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Updating the NLRC4 Inflammasome: from Bacterial Infections to Autoimmunity and Cancer

Frontiers in Immunology, 2021
Inflammasomes comprise a family of cytosolic multi-protein complexes that modulate the activation of cysteine-aspartate-specific protease 1 (caspase-1) and promote the maturation and secretion of interleukin (IL)-1β and IL-18, leading to an inflammatory ...
Jiexia Wen, Bin Xuan, Yang Liu, Liwei Wang, Li He, Xiangcai Meng, Tao Zhou, Yimin Wang, Yimin Wang   +8 more
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Involvement of inflammasomes in tumor microenvironment and tumor therapies

Journal of Hematology & Oncology, 2023
Inflammasomes are macromolecular platforms formed in response to damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation would cause maturation of interleukin-1 (IL-1) family members and gasdermin D (GSDMD)
Ziqi Zhang, Xue Li, Yang Wang, Yuquan Wei, Xiawei Wei   +4 more
doaj   +1 more source