Results 1 to 10 of about 90,432 (374)

The roles of inflammasomes in cancer

Frontiers in Immunology, 2023
Inflammation is a key characteristic of all stages of tumor development, including tumor initiation, progression, malignant transformation, invasion, and metastasis.
Zihan Deng, Lisen Lu, Binghui Li, Xiujuan Shi, Honglin Jin, Weidong Hu   +5 more
doaj   +2 more sources

Involvement of inflammasomes in tumor microenvironment and tumor therapies

Journal of Hematology & Oncology, 2023
Inflammasomes are macromolecular platforms formed in response to damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation would cause maturation of interleukin-1 (IL-1) family members and gasdermin D (GSDMD)
Ziqi Zhang, Xue Li, Yang Wang, Yuquan Wei, Xiawei Wei   +4 more
doaj   +2 more sources

Emerging Roles of Inflammasomes in Cardiovascular Diseases

Frontiers in Immunology, 2022
Cardiovascular diseases are known as the leading cause of morbidity and mortality worldwide. As an innate immune signaling complex, inflammasomes can be activated by various cardiovascular risk factors and regulate the activation of caspase-1 and the ...
Yingnan Liao, Kui Liu, Liyuan Zhu
doaj   +2 more sources

Inflammasomes as therapeutic targets in human diseases

Signal Transduction and Targeted Therapy, 2021
Inflammasomes are protein complexes of the innate immune system that initiate inflammation in response to either exogenous pathogens or endogenous danger signals.
Yangxin Li, Hui Huang, Xi-Yong Yu
exaly   +2 more sources

Targeting inflammasomes as an immunotherapeutic strategy for cancer [PDF]

Journal of Translational Medicine
Inflammasomes are essential regulators of innate immunity, inflammation, and cellular apoptosis, and they have surfaced as significant modulators of cancer progression and regulation.
Luanluan Huang, Xiaoyan Chen, Ruiqi Liu, Ding Nan, Wenxuan Bao, Lixian Yang, Xiaomeng Dai, Jianming Tang, Haibo Zhang, Yanwei Lu   +9 more
doaj   +2 more sources

Inflammasomes: novel therapeutic targets for metabolic syndrome? [PDF]

Frontiers in Endocrinology
Chronic inflammation is a hallmark for Metabolic Syndrome (MetS). It is also one of the most important risk factors for insulin resistance and metabolic disorders.
Pengyu Cao, Pengyu Cao, Yulin Yang, Yulin Yang, Ningning Zhang, Bojian Wang, Zhenwei Gong   +6 more
doaj   +2 more sources

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Nature, 2010
Peter Duewell, Hajime Kono, Katey J Rayner   +2 more
exaly   +4 more sources

Dynamic roles of inflammasomes in inflammatory tumor microenvironment

npj Precision Oncology, 2021
The inflammatory tumor microenvironment has been known to be closely connected to all stages of cancer development, including initiation, promotion, and progression.
Jeong-Hoon Jang, Do-Hee Kim, Young-Joon Surh   +2 more
doaj   +2 more sources

The role of inflammasomes in human diseases and their potential as therapeutic targets

Signal Transduction and Targeted Therapy
Inflammasomes are large protein complexes that play a major role in sensing inflammatory signals and triggering the innate immune response. Each inflammasome complex has three major components: an upstream sensor molecule that is connected to a ...
Zhe Wang, Weihong Song
exaly   +2 more sources

The lncRNA Neat1 promotes activation of inflammasomes in macrophages

Nature Communications, 2019
The inflammasome has an essential function in innate immune, responding to a wide variety of stimuli. Here we show that the lncRNA Neat1 promotes the activation of several inflammasomes.
Rongbin Zhou, Xiaolu Yang, Mian Wu
exaly   +2 more sources