Results 11 to 20 of about 47,495 (266)

Pan-cancer analysis of AIM2 inflammasomes with potential implications for immunotherapy in human cancer: A bulk omics research and single cell sequencing validation

Frontiers in Immunology, 2022
BackgroundThe absent in melanoma 2 (AIM2) inflammasome is a multi-protein platform that recognizes aberrant cytoplasmic double-stranded DNA(dsDNA) and induces cytokine maturation, release, and pyroptosis. Some studies found that the AIM2 inflammasome was
Yan Qin, Liuxian Pan, Tianyu Qin, Hanyi Ruan, Yujie Zhang, Yan Zhang, Jianli Li, Jianrong Yang, Wei Li   +8 more
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Dynamic roles of inflammasomes in inflammatory tumor microenvironment

npj Precision Oncology, 2021
The inflammatory tumor microenvironment has been known to be closely connected to all stages of cancer development, including initiation, promotion, and progression.
Jeong-Hoon Jang, Do-Hee Kim, Young-Joon Surh   +2 more
doaj   +1 more source

Exploring Inflammasome Complex as a Therapeutic Approach in Inflammatory Diseases

Future Pharmacology, 2023
Inflammasomes, a group of multiprotein complexes, are essential in regulating inflammation and immune responses. Several inflammasomes, including nucleotide-binding domain leucine-rich repeat-containing protein 1 (NLRP1), NLRP3, NLRP6, NLRP7, NLRP12 ...
Sharmim Sultana, Thanh Doan Viet, Tasmiha Amin, Esha Kazi, Luigina Micolucci, Abul Kalam Mohammad Moniruzzaman Mollah, Most Mauluda Akhtar, Md Soriful Islam   +7 more
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Inflammasomes as Targets for Adjuvants

Pathogens, 2020
Inflammasomes are an essential part of the innate immune system. They are necessary for the development of a healthy immune response against infectious diseases.
Konstantin Ivanov, Ekaterina Garanina, Albert Rizvanov, Svetlana Khaiboullina   +3 more
doaj   +1 more source

Activation of Nlrp3 inflammasomes enhances macrophage lipid-deposition and migration: implication of a novel role of inflammasome in atherogenesis. [PDF]

PLoS ONE, 2014
Although Nlrp3 inflammasome activation in macrophages has been shown to be critical for the development of atherosclerosis upon atherogenic stimuli, it remains unknown whether activated Nlrp3 inflammasomes by other non-atherogenic stimuli induce ...
Xiang Li, Yang Zhang, Min Xia, Erich Gulbins, Krishna M Boini, Pin-Lan Li   +5 more
doaj   +1 more source

Non-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases

Journal of Inflammation Research, 2021
Wei Wang, Ni Yang, Yu-Hang Yang, Ri Wen, Chun-Feng Liu, Tie-Ning Zhang Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of ChinaCorrespondence: Chun-Feng Liu; Tie-Ning ZhangDepartment of Pediatrics ...
Wang W, Yang N, Yang YH, Wen R, Liu CF, Zhang TN   +5 more
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Emerging mechanisms and functions of inflammasome complexes in teleost fish

Frontiers in Immunology, 2023
Inflammasomes are multiprotein complexes, which are assembled in response to a diverse range of exogenous pathogens and endogenous danger signals, leading to produce pro-inflammatory cytokines and induce pyroptotic cell death.
Ming Xian Chang, Ming Xian Chang, Ming Xian Chang   +2 more
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The AIM2 inflammasome is activated in astrocytes during the late phase of EAE

JCI Insight, 2022
Inflammasomes are a class of innate immune signaling platforms that activate in response to an array of cellular damage and pathogens. Inflammasomes promote inflammation under many circumstances to enhance immunity against pathogens and inflammatory ...
William E. Barclay, Nupur Aggarwal, M. Elizabeth Deerhake, Makoto Inoue, Toshiaki Nonaka, Kengo Nozaki, Nathan A. Luzum, Edward A. Miao, Mari L. Shinohara   +8 more
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Inflammasome activation by viral infection: mechanisms of activation and regulation

Frontiers in Microbiology, 2023
Viral diseases are the most common problems threatening human health, livestock, and poultry industries worldwide. Viral infection is a complex and competitive dynamic biological process between a virus and a host/target cell.
Wen Shi, Mengyun Jin, Hao Chen, Zongxue Wu, Liuyang Yuan, Si Liang, Xiaohan Wang, Fareed Uddin Memon, Fatma Eldemery, Hongbin Si, Hongbin Si, Hongbin Si, Changbo Ou, Changbo Ou, Changbo Ou   +14 more
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Erythropoietin Enhances Post-ischemic Migration and Phagocytosis and Alleviates the Activation of Inflammasomes in Human Microglial Cells

Frontiers in Cellular Neuroscience, 2022
Recombinant human erythropoietin (rhEPO) has been shown to exert anti-apoptotic and anti-inflammatory effects after cerebral ischemia. Inflammatory cytokines interleukin-1β and -18 (IL-1β and IL-18) are crucial mediators of apoptosis and are maturated by
Eren Arik, Ole Heinisch, Michaela Bienert, Lara Gubeljak, Alexander Slowik, Arno Reich, Jörg B. Schulz, Jörg B. Schulz, Thomas Wilhelm, Michael Huber, Pardes Habib, Pardes Habib   +11 more
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