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Cell, 2010 Inflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as interleukin-1beta to engage innate immune defenses. Strong associations between dysregulated inflammasome activity and human heritable and acquired inflammatory diseases highlight the importance this pathway
Assoc Prof Kate Schroder
exaly +5 more sources
Journal of Experimental Medicine, 2018 In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation.
Sandstrom, Andrew, VANCE, Russell E.
core +6 more sources
Inflammasomes and Fibrosis [PDF]
Frontiers in Immunology, 2021 Fibrosis is the final common pathway of inflammatory diseases in various organs. The inflammasomes play an important role in the progression of fibrosis as innate immune receptors.
Wen-juan Zhang +4 more
semanticscholar +5 more sources
Activation of Nlrp3 inflammasomes enhances macrophage lipid-deposition and migration: implication of a novel role of inflammasome in atherogenesis. [PDF]
PLoS ONE, 2014 Although Nlrp3 inflammasome activation in macrophages has been shown to be critical for the development of atherosclerosis upon atherogenic stimuli, it remains unknown whether activated Nlrp3 inflammasomes by other non-atherogenic stimuli induce ...
Xiang Li +5 more
doaj +5 more sources
Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]
EMBO Molecular Medicine, 2019 Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate inflammasomes.
Sofie Voet +3 more
semanticscholar +3 more sources
Regulation of cancer by inflammasomes: from inflammation to tumorigenesis [PDF]
Frontiers in ImmunologyInflammation is closely linked to the development and progression of cancer, as well as the effectiveness of cancer treatment. Inflammation is an immune response triggered when the immune system detects harmful stimuli such as pathogens, damaged cells ...
Shivani Malvankar +3 more
doaj +2 more sources
Inflammasomes and Cancer: The Dynamic Role of the Inflammasome in Tumor Development [PDF]
Frontiers in Immunology, 2017 Chronic Inflammation in tumor microenvironments is not only associated with various stages of tumor development, but also has significant impacts on tumor immunity and immunotherapy.
Melvin Kantono +3 more
doaj +4 more sources
Inflammasomes: mechanism of action, role in disease, and therapeutics
Nature Medicine, 2015 Haitao Guo
exaly +2 more sources
Activation and regulation of the inflammasomes
Nature Reviews Immunology, 2013 Eicke Latz, Andrea Stutz
exaly +2 more sources