Results 21 to 30 of about 90,432 (374)
Molecular Aspects of Medicine, 2020 Ketelut-Carneiro and Fitzgerald discuss the basic concepts about inflammasome composition, assembly and activation, effector functions and role in infection and inflammatory disease.
Natália Ketelut-Carneiro, K. Fitzgerald
semanticscholar +5 more sources
Inflammasomes cross-talk with lymphocytes to connect the innate and adaptive immune response
Journal of Advanced Research, 2023 Background: Innate and adaptive immunity are two different parts of the immune system that have different characteristics and work together to provide immune protection. Inflammasomes are a major part of the innate immune system that are expressed widely
Hongliang Zhang +4 more
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Roles of inflammasomes in viral myocarditis
Frontiers in Cellular and Infection Microbiology, 2023 Viral myocarditis (VMC), characterized by viral infection-induced inflammation, is a life-threatening disease associated with dilated cardiomyopathy or heart failure.
Jingyu Xu +5 more
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Inflammasomes and Colorectal Cancer
Cells, 2021 Inflammasomes are important intracellular multiprotein signaling complexes that modulate the activation of caspase-1 and induce levels of the proinflammatory cytokines interleukin-1β (IL-1β) and IL-18 in response to pathogenic microorganisms and ...
Sanaz Keshavarz Shahbaz +5 more
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Cold Spring Harbor Perspectives in Biology, 2014 Inflammasomes are large cytosolic multiprotein complexes that assemble in response to detection of infection- or stress-associated stimuli and lead to the activation of caspase-1-mediated inflammatory responses, including cleavage and unconventional secretion of the leaderless proinflammatory cytokines IL-1β and IL-18, and initiation of an inflammatory
de Zoete, Marcel R +3 more
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Molecules, 2021 In recent years, the interplay between the activation of the immune system, the development of chronic inflammation and the onset and progression of many different diseases has been studied extensively [...]
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Immunology, 2020 SummaryThe NOD‐like receptor family pyrin domain containing 6 (NLRP6), a member of the NOD‐like receptor (NLR) family, acts as a cytosolic innate immune sensor that recognizes microbe‐associated molecular patterns. In some circumstances upon activation, NLRP6 recruits the adaptor apoptosis‐associated speck‐like protein (ASC) and the inflammatory ...
Lara Kern +3 more
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Updating the NLRC4 Inflammasome: from Bacterial Infections to Autoimmunity and Cancer
Frontiers in Immunology, 2021 Inflammasomes comprise a family of cytosolic multi-protein complexes that modulate the activation of cysteine-aspartate-specific protease 1 (caspase-1) and promote the maturation and secretion of interleukin (IL)-1β and IL-18, leading to an inflammatory ...
Jiexia Wen +8 more
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Inflammasomes and Atherosclerosis: a Mixed Picture.
Circulation Research, 2023 The CANTOS (Canakinumab Anti-inflammatory Thrombosis Outcome Study) and colchicine trials suggest an important role of inflammasomes and their major product IL-1β (interleukin 1β) in human atherosclerotic cardiovascular disease.
A. Tall, K. Bornfeldt
semanticscholar +1 more source