Results 21 to 30 of about 56,139 (234)
Of inflammasomes and pathogens – sensing of microbes by the inflammasome [PDF]
EMBO Molecular Medicine, 2013 Inflammasomes are signalling platforms that sense a diverse range of microbial products and also a number of stress and damage associated endogenous signals. Inflammasome complexes can be formed by members of the Nod-like receptor family or the PYHIN family member AIM2.
Franz Bauernfeind, Veit Hornung
openaire +3 more sources
Inflammasomes and dermatology [PDF]
Anais Brasileiros de Dermatologia, 2016 Inflammasomes are intracellular multiprotein complexes that comprise part of the innate immune response. Since their definition, inflammasome disorders have been linked to an increasing number of diseases. Autoinflammatory diseases refer to disorders in which local factors lead to the activation of innate immune cells, causing tissue damage when in the
Sá, Daniel Coelho de, Festa Neto, Cyro
openaire +5 more sources
Involvement of inflammasomes in tumor microenvironment and tumor therapies
Journal of Hematology & Oncology, 2023 Inflammasomes are macromolecular platforms formed in response to damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation would cause maturation of interleukin-1 (IL-1) family members and gasdermin D (GSDMD)
Ziqi Zhang +4 more
doaj +1 more source
Dynamic roles of inflammasomes in inflammatory tumor microenvironment
npj Precision Oncology, 2021 The inflammatory tumor microenvironment has been known to be closely connected to all stages of cancer development, including initiation, promotion, and progression.
Jeong-Hoon Jang +2 more
doaj +1 more source
Exploring Inflammasome Complex as a Therapeutic Approach in Inflammatory Diseases
Future Pharmacology, 2023 Inflammasomes, a group of multiprotein complexes, are essential in regulating inflammation and immune responses. Several inflammasomes, including nucleotide-binding domain leucine-rich repeat-containing protein 1 (NLRP1), NLRP3, NLRP6, NLRP7, NLRP12 ...
Sharmim Sultana +7 more
doaj +1 more source
Inflammasomes, the eye and anti-inflammasome therapy [PDF]
Eye, 2017 Inflammasomes, key molecular regulators that play an important role in inflammation, consist of a central protein, an adaptor protein ASC (apoptosis speck-like protein) and a caspase-1 protein. Upon activation, caspase-1 induces maturation of cytokines such as interleukin-1β (IL-1β) and interleukin-18 (IL-18).
Mark D. P. Willcox +2 more
openaire +3 more sources
Frontiers in Immunology, 2022 BackgroundThe absent in melanoma 2 (AIM2) inflammasome is a multi-protein platform that recognizes aberrant cytoplasmic double-stranded DNA(dsDNA) and induces cytokine maturation, release, and pyroptosis. Some studies found that the AIM2 inflammasome was
Yan Qin +8 more
doaj +1 more source
Inflammasomes and autoimmunity [PDF]
Trends in Molecular Medicine, 2011 The NOD-like receptor (NLR) family members are cytosolic sensors of microbial components and danger signals. A subset of NLRs control inflammasome assembly that results in caspase-1 activation and, in turn, IL-1β and IL-18 production. Excessive inflammasome activation can cause autoinflammatory disorders, including the hereditary periodic fevers ...
Thirumala-Devi Kanneganti +2 more
openaire +3 more sources
Inflammasomes as Targets for Adjuvants
Pathogens, 2020 Inflammasomes are an essential part of the innate immune system. They are necessary for the development of a healthy immune response against infectious diseases.
Konstantin Ivanov +3 more
doaj +1 more source
Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]
, 2019 Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed +3 more
core +2 more sources