Results 1 to 10 of about 64,551 (115)

Role of Matrix Metalloproteinases and Tissue Inhibitors in Sepsis Pathogenesis [PDF]

Medical Sciences
Background: This study investigates the role of MMPs and TIMPs in sepsis pathogenesis. We aim to assess multiple potential biomarkers including MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-13, TIMP-1, TIMP-2, TIMP-3 in serum, brain and kidney tissue samples ...
Rasime Sevgi Cenan, Ayşegül Karaoğlan, Hatice Paşaoğlu   +2 more
doaj   +2 more sources

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Echinoderms: Structure and Possible Functions

Cells, 2021
Echinoderms are one of the most ancient groups of invertebrates. The study of their genomes has made it possible to conclude that these animals have a wide variety of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs ...
Igor Yu. Dolmatov, Vladimir A. Nizhnichenko, Lyudmila S. Dolmatova   +2 more
doaj   +3 more sources

Matrix Metalloproteinases/Tissue Inhibitors of Metalloproteinases Ratio: A Biomarker of Bone Resorption in Geriatric Osteoporosis? [PDF]

Annals of Geriatric Medicine and Research, 2023
Background Matrix metalloproteinases (MMPs) play an important role in bone resorption and are regulated by tissue inhibitors of metalloproteinases (TIMPs).
Bahar Bektan Kanat, Gulru Ulugerger Avci, Osman Faruk Bayramlar, Damla Unal, Ozge Sonmez, Ibrahim Murat Bolayirli, Alper Doventas, Deniz Suna Erdincler, Hakan Yavuzer   +8 more
doaj   +1 more source

Polymerizable Matrix Metalloproteinases’ Inhibitors with Potential Application for Dental Restorations

Biomedicines, 2021
Collagen cleavage by matrix metalloproteinase (MMP) is considered a major cause of dental resins long term failure. Most MMP inhibitors display significant toxicity and are unsuitable for dental resins’ applications. Here we report a study of a new class
Helena Laronha, Inês Carpinteiro, Jaime Portugal, Ana Azul, Mário Polido, Krasimira T. Petrova, Madalena Salema-Oom, Isabel Barahona, Jorge Caldeira   +8 more
doaj   +1 more source

Challenges in Matrix Metalloproteinases Inhibition

Biomolecules, 2020
Matrix metalloproteinases are enzymes that degrade the extracellular matrix. They have different substrates but similar structural organization. Matrix metalloproteinases are involved in many physiological and pathological processes and there is a need ...
Helena Laronha, Inês Carpinteiro, Jaime Portugal, Ana Azul, Mário Polido, Krasimira T. Petrova, Madalena Salema-Oom, Jorge Caldeira   +7 more
doaj   +1 more source

The serum levels of circulating matrix metalloproteinase MMP-9, MMP-2/TIMP-2 complex and TIMP-1 do not change significantly during normal pregnancy: a pilot study

BMC Research Notes, 2021
Objective Matrix metalloproteinases (MMPs) are important regulators of vascular and uterine remodeling. They exhibit proteolytic activity implicating the efficiency of trophoblast invasion to the uterine wall involving marked hemodynamic and uterine ...
Ritva Nissi, Markku Santala, Anne Talvensaari-Mattila   +2 more
doaj   +1 more source

The possibilities of using the inhibitors of matrix metalloproteinases for keratoplasty

Трансплантология (Москва), 2023
Introduction. The review is devoted to the actual problem of treating patients with keratolysis. The role of matrix metalloproteinases in the pathogenesis of cornea and corneal graft melting is discussed as well as the practical experience of using ...
K. V. Sirotkina, E. V. Chentsova
doaj   +1 more source

Targeting matrix metalloproteinase MMP3 greatly enhances oncolytic virus mediated tumor therapy

Translational Oncology, 2021
In cancer, the extracellular matrix is extensively remodeled during chronic inflammation, thus affecting cell transcription, differentiation, migration and cell-cell interactions.
Minglong Liang, Jian Wang, Chuanjian Wu, Manman Wu, Jingping Hu, Jianfeng Dai, Hang Ruan, Sidong Xiong, Chunsheng Dong   +8 more
doaj   +1 more source

Production of factors involved into fibrosis regulation by various types of human macrophages

Медицинская иммунология, 2020
Macrophages (Mφ) play a key role in regulation of fibrogenesis, including proliferation of fibroblasts and  myofibroblasts, differentiation of progenitor cells into  myofibroblasts, as well as synthesis  and  secretion of the  extracellular matrix ...
A. A. Maksimova, E. Ya. Shevela, L. V. Sakhno, A. A. Ostanin, E. R. Chernykh   +4 more
doaj   +1 more source

Matrix metalloproteinases and their inhibitors

Фармакокинетика и Фармакодинамика, 2019
Metalloproteinase was discovered by Gross and Lapierre in 1962 for the first time. Since then, more than 20 enzymes of this family have been characterized, and their functions have been studied in detail.
O. S. Grigorkevich, G. V. Mokrov, L. Yu. Kosova   +2 more
doaj   +1 more source