Results 21 to 30 of about 166,084,760 (290)

The regulation of matrix metalloproteinases and their inhibitors [PDF]

The International Journal of Biochemistry & Cell Biology, 2008
The matrix metalloproteinases (MMP) are a family of 23 enzymes in man. These enzymes were originally described as cleaving extracellular matrix (ECM) substrates with a predominant role in ECM homeostasis, but it is now clear that they have much wider functionality.
Clark, Ian M., Swingler, Tracey E., Sampieri, Clara L., Edwards, Dylan R.   +3 more
openaire   +3 more sources

Exogenously added GPI-anchored tissue inhibitor of matrix metal loproteinase-1 (TIMP-1) displays enhanced and novel biological activities [PDF]

, 2004
The family of tissue inhibitors of metalloproteinases (TIMPs) exhibits diverse physiological/biological functions including the inhibition of active matrix metalloproteinases, regulation of proMMP activation, cell growth, and the modulation of ...
P.J. Nelson, Belen Vicente, A., R. Djafarzadeh, Mojaat, A., Nelson, P. J., Djafarzadeh, R., Lüttichau, I. von, I. von Lüttichau, A. Belen Vicente, A. Mojaat   +9 more
core   +1 more source

The relationship between the first episode of wheezing and matrix metalloproteinases-9 and MMP-2 and tissue inhibitors of MMP-1 levels in preterm infants

Annals of Thoracic Medicine, 2013
Aims: Matrix metalloproteinases (MMP) have been associated with neonatal lung morbidity and MMP dysregulation contributes to the pathology of chronic and acute lung disorders.
Rabia Gonul Sezer, Gokhan Aydemir, Abdulkadir Bozaykut, Serdar Hira, Ilhan Asya Tanju, Ömer Özcan   +5 more
doaj   +1 more source

Matrix metalloproteinases at key junctions in the pathomechanism of stroke [PDF]

, 2011
Matrix metalloproteinases play a crucial role in the remodelling of the extracellular matrix through direct degradation of its structural proteins and control of extracellular signaling.
Kolev, Kraszimir, Kolev Krasimir, Rottenberger Zsolt, Zsolt Rottenberger, Rottenberger, Zsolt, Krasimir Kolev   +5 more
core   +1 more source

Biochemical markers assessing rate of reparative processes in patients with infiltrative pulmonary tuberculosis

Инфекция и иммунитет, 2023
Theeffectiveness of chemotherapy for infiltrative pulmonary tuberculosis (ITL) is determined by proper timing and adequacy of treatment. The speed of reparative changes in the pulmonary parenchyma is associated with the effectiveness of therapy ...
Dilyara S. Esmedlyaeva, Nina P. Alekseeva, Marina E. Dyakova   +2 more
doaj   +1 more source

Activity of matrix metalloproteinases and their tissue inhibitors in serum in chronic granulating periodontitis

Patologìâ, 2019
Aim. The aim of the work is to study the activity of matrix metalloproteinases and their tissue inhibitors in chronic granular periodontitis. Materials and methods. We examined serum of 15 patients with chronic granulating periodontitis and 15 healthy
D. I. Haidash, I. S. Haidash, O. О. Bondar, Yu. О. Yevtushenko, O. I. Haidash   +4 more
doaj   +1 more source

Distinct Metalloproteinase Expression and Functions in Systemic Sclerosis and Fibrosis: What We Know and the Potential for Intervention

Frontiers in Physiology, 2021
Systemic sclerosis (SSc) is a chronic debilitating idiopathic disorder, characterized by deposition of excessive extracellular matrix (ECM) proteins such as collagen which leads to fibrosis of the skin and other internal organs.
Edwin Leong, Michael Bezuhly, Michael Bezuhly, Jean S. Marshall, Jean S. Marshall   +4 more
doaj   +1 more source

Metalloproteinases and Their Inhibitors: Potential for the Development of New Therapeutics

Cells, 2020
The metalloproteinase (MP) family of zinc-dependent proteases, including matrix metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) plays a crucial role in ...
Maryam Raeeszadeh-Sarmazdeh, Linh D. Do, Brianne G. Hritz   +2 more
doaj   +1 more source

Clinical Investigation of Matrix Metalloproteinases, Tissue Inhibitors of Matrix Metalloproteinases, and Matrix Metalloproteinase/Tissue Inhibitors of Matrix Metalloproteinase Complexes and Their Networks in Apical Periodontitis [PDF]

Journal of Endodontics, 2016
This clinical study investigated the levels of metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) and respective forms (MMP/TIMP complexes) in apical periodontitis to determine their networks in the development of clinical/radiographic features, thus quantifying the levels of endotoxins (lipopolysaccharides) present in primarily infected ...
Frederico C. Martinho, Flávia F.C. Teixeira, Flávia G.R. Cardoso, Nádia S. Ferreira, Gustavo G. Nascimento, Cláudio A.T. Carvalho, Márcia C. Valera   +6 more
openaire   +3 more sources

Induced sputum MMP-1, -3 & -8 concentrations during treatment of tuberculosis. [PDF]

, 2013
INTRODUCTION: Tuberculosis (TB) destroys lung tissues and this immunopathology is mediated in part by Matrix Metalloproteinases (MMPs). There are no data on the relationship between local tissue MMPs concentrations, anti-tuberculosis therapy and sputum ...
Jorge Coronel, Friedland, Jon S, Bernabe-Ortiz, A., Coronel, Jorge, Gotuzzo, E., Gotuzzo Eduardo, Antonio Bernabe-Ortiz, Moore, David AJ, Ugarte-Gil, C.A., Coronel Jorge, Elkington, P.T., Moore, D.A.J., Eduardo Gotuzzo, Coronel, J., Paul Elkington, Robert H Gilman, Moore David A. J., Friedland, J.S., Gilman, R., Elkington Paul, Ugarte-Gil, Cesar A, Bernabe-Ortiz Antonio, Gilman Robert H., Cesar A Ugarte-Gil, Friedland Jon S., Elkington, Paul, Jon S Friedland, Gotuzzo, Eduardo, David A J Moore, Ugarte-Gil Cesar A., Tezera, Liku B, Gilman, Robert H, Liku B Tezera, Tezera Liku B., Bernabe-Ortiz, Antonio   +34 more
core   +1 more source