Results 241 to 250 of about 166,084,760 (290)

Matrix Metalloproteinase Inhibitors

BioDrugs, 1998
The matrix metalloproteinases (MMPs) are a family of closely related, zinc-dependent proteolytic enzymes. Collectively, they are capable of degrading all the components of the extracellular matrix and as such are involved in a number of physiological and pathological processes.
S A, Watson, G, Tierney
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Matrix metalloproteinases and inhibitors in dentistry

Clinical Oral Investigations, 2019
Matrix metalloproteinase (MMP) expression has been associated with tissue development, invasive cancer cell behavior, and inflammation. The associations of increased expression of MMPs with diseases have led to intensive research activities to develop MMP inhibitors.
Gerd-Jan Boelen, Lucas Boute, Joëy d’Hoop, Mostafa EzEldeen, Ivo Lambrichts, Ghislain Opdenakker   +5 more
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Matrix Metalloproteinases and Their Inhibitors

2001
Matrix metalloproteinases (MMPs) are a group of 16 enzymes that are capable of degrading extracellular matrix components. Their catalytic function is dependent on a zinc ion in the active center. MMPs are separated in three groups: gelatinases (type IV-collagenases), stromelysins, and interstitial collagenases.
A, Kugler, P, Thelen, R H, Ringert
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Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in kidney disease

2021
Matrix metalloproteinases (MMPs) are a group of zinc and calcium endopeptidases which cleave extracellular matrix (ECM) proteins. They are also involved in the degradation of cell surface components and regulate multiple cellular processes, cell to cell interactions, cell proliferation, and cell signaling pathways.
Oskar, Zakiyanov, Marta, Kalousová, Tomáš, Zima, Vladimír, Tesař   +3 more
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Inhibitors of matrix metallaproteinases

2006
The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and methods of using compounds of formulas I-IX. The compounds of the invention can be used to inhibit matrix metalloproteinases, and are useful to treat ...
LEE MIJOON, IKEJIRI MASAHIRO, CHANG MAYLAND, FRIDMAN RAFAEL, MOBASHERY SHAHRIAR   +4 more
openaire   +4 more sources

Matrix metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury☆

Human Pathology, 2006
The objective of this study was to assess matrix metalloproteinase (MMP) and MMP inhibitor expression in the airspace of patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) and to determine the prognostic significance of MMP expression in this patient population.
Suzanne E G, Fligiel, Theodore, Standiford, Helene M, Fligiel, Donald, Tashkin, Robert M, Strieter, Roscoe L, Warner, Kent J, Johnson, James, Varani   +7 more
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Matrix metalloproteinases and matrix metalloproteinase inhibitors in lung cancer

Seminars in Oncology, 2002
Preclinical studies have provided evidence that matrix metalloproteinases (MMPs), a family of zinc-containing proteolytic enzymes, facilitate tumor invasion, the establishment of metastases, and the promotion of tumor-related angiogenesis. Matrix metalloproteinase inhibitors (MMPIs) have been shown to inhibit tumor growth and dissemination in ...
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Matrix metalloproteinases and metalloproteinase inhibitors in human interphotoreceptor matrix and vitreous

Current Eye Research, 1998
We wished to establish which matrix metalloproteinases (MMPs) and metalloproteinase inhibitors (TIMPs) were present in human interphotoreceptor matrix (IPM) and vitreous.IPM and vitreous were obtained from postmortem human eyebank eyes. Western immunoblots were probed with antibodies against human MMPs and TIMPs.
J J, Plantner, A, Smine, T A, Quinn
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Metalloproteinases and their inhibitors in matrix remodeling

Trends in Genetics, 1990
The matrix metalloproteinases are a tightly regulated family of enzymes that degrade extracellular matrix and basement membrane components. Recent evidence suggests that these proteases and their specific inhibitors play important roles in normal developmental processes and in pathological conditions.
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Transcriptional Control of Matrix Metalloproteinases and the Tissue Inhibitors of Matrix Metalloproteinases

Critical Reviews™ in Eukaryotic Gene Expression, 1997
Matrix metalloproteinases (MMPs) are enzymes with important roles in a variety of normal physiological processes; these same enzymes are also operative in a range of pathologies. The proteins known as the tissue inhibitors of matrix metalloproteinases (TIMPs) act to limit the enzymatic function of the MMPs. MMPs and TIMPs can be divided into two groups
P, Borden, R A, Heller
openaire   +2 more sources