Results 231 to 240 of about 166,084,760 (290)

MMP9 Knockout by CRISPR-Cas9 Reduces Bladder Cancer Malignancy But Does Not Synergize With BCG and Anti-PD-L1 in an Orthotopic Mouse Model. [PDF]

open access: yesIUBMB Life
Camargo JA   +13 more
europepmc   +1 more source

Matrix metalloproteinase inhibitors

Investigational New Drugs, 1997
The matrix metalloproteinases (MMPs) are a family of at least fifteen secreted and membrane-bound zinc-endopeptidases. Collectively, these enzymes can degrade all of the components of the extracellular matrix, including fibrallar and non-fibrallar collagens, fibronectin, laminin and basement membrane glycoproteins.
S M, Wojtowicz-Praga   +2 more
  +9 more sources

Matrix metalloproteinase inhibitors

Current Oncology Reports, 2004
Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are associated with the tumorigenic process. MMPs degrade the extracellular matrix, promoting tumor invasion and metastasis. They also regulate host defense mechanisms and normal cell function; blocking all MMPs may not lead to a positive therapeutic outcome. Most clinical
Nithya, Ramnath, Patrick J, Creaven
openaire   +7 more sources

The Matrix Metalloproteinases and Their Inhibitors

American Journal of Respiratory Cell and Molecular Biology, 1992
Abstract A number of metalloproteinases that degrade the extracellular matrix of connective tissues and two specific tissue inhibitors of metalloproteinases (TIMPs) have now been isolated, characterized, and cloned. Comparison of the enzyme sequences has allowed the delineation of domain structures, and initial studies have been ...
G, Murphy, A J, Docherty
openaire   +2 more sources

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