Cortical PV and VIP interneurons similarly influence SST neuron output despite distinct unitary properties [PDF]
Communications BiologySomatostatin (SST) expressing cells are powerful inhibitors of excitatory pyramidal neurons. It has been shown that SST cells are targeted by other inhibitory interneurons, namely parvalbumin- (PV) and vasoactive intestinal polypeptide- (VIP) expressing ...
Felix Preuss +3 more
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Melatonin suppresses abnormal hyperexcitability of hippocampal CA1 neurons in early-stage oxygen-glucose deprivation [PDF]
Frontiers in PharmacologyExcitotoxicity in the early stages of ischemia is a primary trigger of neuronal injury. Literature has indicated the potential neuroprotective effects of melatonin against ischemic hypoxic injury, but the direct electrophysiological mechanisms underlying
Yang Cui, Qi Wang, Chao Liu, Heng Zhou
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Imperfect space clamp permits electrotonic interactions between inhibitory and excitatory synaptic conductances, distorting voltage clamp recordings. [PDF]
PLoS ONE, 2011 The voltage clamp technique is frequently used to examine the strength and composition of synaptic input to neurons. Even accounting for imperfect voltage control of the entire cell membrane ("space clamp"), it is often assumed that currents measured at ...
Alon Poleg-Polsky, Jeffrey S Diamond
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Postsynaptic activity of inhibitory neurons evokes hemodynamic fMRI responses
NeuroImage, 2021 Functional MRI responses are localized to the synaptic sites of evoked inhibitory neurons, but it is unknown whether, or by what mechanisms, these neurons initiate functional hyperemia.
Alexander John Poplawsky +4 more
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Visualization by high resolution immunoelectron microscopy of the transient receptor potential vanilloid-1 at inhibitory synapses of the mouse dentate gyrus. [PDF]
PLoS ONE, 2015 We have recently shown that the transient receptor potential vanilloid type 1 (TRPV1), a non-selective cation channel in the peripheral and central nervous system, is localized at postsynaptic sites of the excitatory perforant path synapses in the ...
Miren-Josune Canduela +7 more
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Spiking Neural P Systems with Membrane Potentials, Inhibitory Rules, and Anti-Spikes
Entropy, 2022 Spiking neural P systems (SN P systems for short) realize the high abstraction and simulation of the working mechanism of the human brain, and adopts spikes for information encoding and processing, which are regarded as one of the third-generation neural
Yuping Liu, Yuzhen Zhao
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Frontiers in Synaptic Neuroscience, 2022 Synaptic plasticity is a critical process that regulates neuronal activity by allowing neurons to adjust their synaptic strength in response to changes in activity.
Caitlyn A. Chapman +2 more
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Modeling Calcium Dynamics and Inhibition Based Synaptic Plasticity in Dendritic Spines
Mathematical Modelling and Analysis, 2014 Inhibitory synapses through GABAergic channels not only change spine's calcium dynamics but also modulate postsynaptic current mediated through glutamate receptors.
Muhammad Dur-e-Ahmad
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Neuromodulation of Chemical Synaptic Transmission Driven by THz Photons
Research, 2022 Postsynaptic currents of chemical synapse are modulated by multitudinous neurotransmitters, such as acetylcholine, dopamine, glutamate, and γ-aminobutyric acid, many of which have been used in the treatment of neurological diseases.
Xiaoxuan Tan +3 more
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Spike-timing dependent plasticity in inhibitory circuits
Frontiers in Synaptic Neuroscience, 2010 Inhibitory circuits in the brain rely on GABA-releasing interneurons. For long, inhibitory circuits were considered weakly plastic in the face of patterns of neuronal activity that trigger long-term changes in the synapses between excitatory principal ...
Karri P Lamsa +2 more
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