Results 1 to 10 of about 71,654 (304)

Effect of standing posture on inhibitory postsynaptic potentials in gastrocnemius motoneurons [PDF]

Journal of Neurophysiology, 2018
This study examined the task dependence of sensory inputs on motoneuron excitability by comparing the inhibitory postsynaptic potential (IPSP) evoked by stimulation of the sural nerve between a standing postural task (Free Standing) and a comparable voluntary isometric contraction performed in a supine position (Lying Supine).
S. J. Garland, A. Gallina, C. L. Pollock, T. D. Ivanova   +3 more
openaire   +5 more sources

Efavirenz restored NMDA receptor dysfunction and inhibited epileptic seizures in GluN2A/Grin2a mutant mice

Frontiers in Neuroscience, 2023
IntroductionN-methyl-D-aspartate receptor (NMDAR) is one of the main receptor of the excitatory neurotransmitter glutamate in the brain, which is the key determinant of the excitatory/inhibitory balance of neural network.
Teng Zhao, Rui Zhong, Xinyue Zhang, Guangjian Li, Chunkui Zhou, Shaokuan Fang, Ying Ding, Weihong Lin   +7 more
doaj   +1 more source

Nitric oxide signalling modulates synaptic inhibition in the superior paraolivary nucleus (SPN) via cGMP-dependent suppression of KCC2

Frontiers in Neural Circuits, 2014
Glycinergic inhibition plays a central role in the auditory brainstem circuitries involved in sound localization and in the encoding of temporal action potential firing patterns.
Lina eYassin, Susanne eRadtke-Schuller, Hila eAsraf, Benedikt eGrothe, Michal eHershfinkel, Ian D Forsythe, Conny eKopp-Scheinpflug   +6 more
doaj   +1 more source

Phenomenological incorporation of nonlinear dendritic integration using integrate-and-fire neuronal frameworks. [PDF]

PLoS ONE, 2013
It has been discovered recently in experiments that the dendritic integration of excitatory glutamatergic inputs and inhibitory GABAergic inputs in hippocampus CA1 pyramidal neurons obeys a simple arithmetic rule as V(S)(Exp) ≈ V(E)(Exp) + V(I)(Exp) + kV(
Douglas Zhou, Songting Li, Xiao-hui Zhang, David Cai   +3 more
doaj   +1 more source

Imbalance of Excitation and Inhibition at Threshold Level In the Auditory Cortex

Frontiers in Neural Circuits, 2015
The interplay of cortical excitation and inhibition is a fundamental feature of cortical information processing. Excitation and inhibition in single cortical neurons are balanced in their response to optimal sensory stimulation due to thalamocortical ...
Yan eZhao, Yan eZhao, Zizhen eZhang, Xiuping eLiu, Colin eXiong, Zhongju eXiao, Jun eYan   +6 more
doaj   +1 more source

Functional maps of neocortical local circuitry

Frontiers in Neuroscience, 2007
This review aims to summarize data obtained with different techniques to provide a functional map of the local circuit connections made by neocortical neurones, a reference for those interested in cortical circuitry and the numerical information required
Alex M Thomson, Christophe Lamy
doaj   +1 more source

Changes in synaptic transmission of substantia gelatinosa neurons after spinal cord hemisection revealed by analysis using in vivo patch-clamp recording

Molecular Pain, 2016
Background After spinal cord injury, central neuropathic pain develops in the majority of spinal cord injury patients. Spinal hemisection in rats, which has been developed as an animal model of spinal cord injury in humans, results in hyperexcitation of ...
Yuji Kozuka MD, Mikito Kawamata MD, Hidemasa Furue PhD, Takashi Ishida MD, Satoshi Tanaka MD, Akiyoshi Namiki MD, Michiaki Yamakage MD   +6 more
doaj   +1 more source

Disruption of KCC2 in Parvalbumin-Positive Interneurons Is Associated With a Decreased Seizure Threshold and a Progressive Loss of Parvalbumin-Positive Interneurons

Frontiers in Molecular Neuroscience, 2022
GABAA receptors are ligand-gated ion channels, which are predominantly permeable for chloride. The neuronal K-Cl cotransporter KCC2 lowers the intraneuronal chloride concentration and thus plays an important role for GABA signaling. KCC2 loss-of-function
Tanja Herrmann, Melanie Gerth, Ralf Dittmann, Daniel Pensold, Martin Ungelenk, Lutz Liebmann, Christian A. Hübner   +6 more
doaj   +1 more source

Membrane-derived phospholipids control synaptic neurotransmission and plasticity. [PDF]

PLoS Biology, 2015
Synaptic communication is a dynamic process that is key to the regulation of neuronal excitability and information processing in the brain. To date, however, the molecular signals controlling synaptic dynamics have been poorly understood.
Victoria García-Morales, Fernando Montero, David González-Forero, Guillermo Rodríguez-Bey, Laura Gómez-Pérez, María Jesús Medialdea-Wandossell, Germán Domínguez-Vías, José Manuel García-Verdugo, Bernardo Moreno-López   +8 more
doaj   +1 more source

Single dendrite-targeting interneurons generate branch-specific inhibition.

Frontiers in Neural Circuits, 2014
Microcircuits composed of dendrite-targeting inhibitory interneurons and pyramidal cells are fundamental elements of cortical networks, however, the impact of individual interneurons on pyramidal dendrites is unclear.
Caleb eStokes, Corinne eTeeter, Jeffry eIsaacson   +2 more
doaj   +1 more source