Results 1 to 10 of about 276,610 (317)

Characteristics of long-duration inhibitory postsynaptic potentials in rat neocortical neuronsin vitro [PDF]

open access: green, 1987
1. The characteristics of long-duration inhibitory postsynaptic potentials (l-IPSPs) which are evoked in rat frontal neocortical neurons by local electrical stimulation were investigated with intracellular recordings from anin vitro slice preparation.
James R. Howe   +2 more
openalex   +4 more sources

GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistance.

open access: goldPLoS Pathogens, 2019
Glutamate-gated chloride channel receptors (GluClRs) mediate inhibitory neurotransmission at invertebrate synapses and are primary targets of parasites that impact drastically on agriculture and human health.
Mohammed Atif   +7 more
doaj   +3 more sources

Heterosynaptic Regulation of α2A-Adrenoceptors on Glutamate/GABA Release in the Prefrontal Cortex of Rats [PDF]

open access: yesBiomedicines
Background/Objectives: Norepinephrine (NE) plays a crucial role in modulating cognitive processes via α2A-adrenoceptors (α2A-ARs) within the prefrontal cortex (PFC), an essential brain region responsible for higher cognitive functions.
Yaru Wei   +5 more
doaj   +2 more sources

Imperfect space clamp permits electrotonic interactions between inhibitory and excitatory synaptic conductances, distorting voltage clamp recordings. [PDF]

open access: yesPLoS ONE, 2011
The voltage clamp technique is frequently used to examine the strength and composition of synaptic input to neurons. Even accounting for imperfect voltage control of the entire cell membrane ("space clamp"), it is often assumed that currents measured at ...
Alon Poleg-Polsky, Jeffrey S Diamond
doaj   +1 more source

Postsynaptic activity of inhibitory neurons evokes hemodynamic fMRI responses

open access: yesNeuroImage, 2021
Functional MRI responses are localized to the synaptic sites of evoked inhibitory neurons, but it is unknown whether, or by what mechanisms, these neurons initiate functional hyperemia.
Alexander John Poplawsky   +4 more
doaj   +1 more source

Visualization by high resolution immunoelectron microscopy of the transient receptor potential vanilloid-1 at inhibitory synapses of the mouse dentate gyrus. [PDF]

open access: yesPLoS ONE, 2015
We have recently shown that the transient receptor potential vanilloid type 1 (TRPV1), a non-selective cation channel in the peripheral and central nervous system, is localized at postsynaptic sites of the excitatory perforant path synapses in the ...
Miren-Josune Canduela   +7 more
doaj   +1 more source

Spiking Neural P Systems with Membrane Potentials, Inhibitory Rules, and Anti-Spikes

open access: yesEntropy, 2022
Spiking neural P systems (SN P systems for short) realize the high abstraction and simulation of the working mechanism of the human brain, and adopts spikes for information encoding and processing, which are regarded as one of the third-generation neural
Yuping Liu, Yuzhen Zhao
doaj   +1 more source

The Yin and Yang of GABAergic and Glutamatergic Synaptic Plasticity: Opposites in Balance by Crosstalking Mechanisms

open access: yesFrontiers in Synaptic Neuroscience, 2022
Synaptic plasticity is a critical process that regulates neuronal activity by allowing neurons to adjust their synaptic strength in response to changes in activity.
Caitlyn A. Chapman   +2 more
doaj   +1 more source

Neuromodulation of Chemical Synaptic Transmission Driven by THz Photons

open access: yesResearch, 2022
Postsynaptic currents of chemical synapse are modulated by multitudinous neurotransmitters, such as acetylcholine, dopamine, glutamate, and γ-aminobutyric acid, many of which have been used in the treatment of neurological diseases.
Xiaoxuan Tan   +3 more
doaj   +1 more source

Efavirenz restored NMDA receptor dysfunction and inhibited epileptic seizures in GluN2A/Grin2a mutant mice

open access: yesFrontiers in Neuroscience, 2023
IntroductionN-methyl-D-aspartate receptor (NMDAR) is one of the main receptor of the excitatory neurotransmitter glutamate in the brain, which is the key determinant of the excitatory/inhibitory balance of neural network.
Teng Zhao   +7 more
doaj   +1 more source

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