Results 91 to 100 of about 521,946 (359)

Disinhibition-Mediated LTP in the Hippocampus is Synapse Specific

Frontiers in Cellular Neuroscience, 2011
Paired pre- and postsynaptic activity in area CA1 of the hippocampus induces long-term inhibitory synaptic plasticity at GABAergic synapses. This pairing-induced GABAergic plasticity weakens synaptic inhibition due to a depolarization of the reversal ...
Jake eOrmond, Jake eOrmond, Melanie A Woodin   +2 more
doaj   +1 more source

Vascularized human cortical organoids (vOrganoids) model cortical development in vivo.

PLoS Biology, 2020
Modeling the processes of neuronal progenitor proliferation and differentiation to produce mature cortical neuron subtypes is essential for the study of human brain development and the search for potential cell therapies. We demonstrated a novel paradigm
Yingchao Shi, Le Sun, Mengdi Wang, Jianwei Liu, Suijuan Zhong, Rui Li, Peng Li, Lijie Guo, Ai Fang, Ruiguo Chen, Woo-Ping Ge, Qian Wu, Xiaoqun Wang   +12 more
doaj   +1 more source

Firing Cell: An Artificial Neuron with a Simulation of Long-Term-Potentiation-Related Memory [PDF]

ISAROB 2006, pp.731-734, 2017
We propose a computational model of neuron, called firing cell (FC), properties of which cover such phenomena as attenuation of receptors for external stimuli, delay and decay of postsynaptic potentials, modification of internal weights due to propagation of postsynaptic potentials through the dendrite, modification of properties of the analog memory ...
arxiv  

Probabilistic Fluorescence-Based Synapse Detection [PDF]

, 2016
Brain function results from communication between neurons connected by complex synaptic networks. Synapses are themselves highly complex and diverse signaling machines, containing protein products of hundreds of different genes, some in hundreds of ...
Aguerrebere, Cecilia, Collman, Forrest, Micheva, Kristina D., Sapiro, Guillermo, Simhal, Anish K., Smith, Stephen J., Vogelstein, Joshua T., Weinberg, Richard J.   +7 more
core   +4 more sources

Synchronized bursts of miniature inhibitory postsynaptic currents

Journal of Physiology, 2010
Spike‐independent miniature postsynaptic currents are generally stochastic and are therefore not thought to mediate information relay in neuronal circuits.
Ion R. Popescu, Linda A. Morton, Alier J. Franco, S. Di, Y. Ueta, J. Tasker   +5 more
semanticscholar   +1 more source

Organic Ferroelectric Synaptic Transistors for Neural Image Recognition Networks

Advanced Materials Interfaces, EarlyView.
All organic transistors, where both the dielectric and semiconducting layers are polymeric, are developed as electrical synaptic devices. Two copolymers of PVDF as the dielectric layer with large differences in their saturation polarizability and memory window are chosen.
Evan Restuccia, Arash Ghobadi, Suchismita Guha   +2 more
wiley   +1 more source

Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in male rats

Neurobiology of Disease, 2022
Aberrant glucocorticoid signaling via glucocorticoid receptors (GR) plays a critical role in alcohol use disorder (AUD). Acute alcohol withdrawal and protracted abstinence in dependent rats are associated with increased GR signaling and changes in GR ...
Sophia Khom, Larry Rodriguez, Pauravi Gandhi, Dean Kirson, Michal Bajo, Christopher S. Oleata, Leandro F. Vendruscolo, Barbara J. Mason, Marisa Roberto   +8 more
doaj  

Paired‐pulse depression of monosynaptic GABA‐mediated inhibitory postsynaptic responses in rat hippocampus.

Journal of Physiology, 1990
1. Intracellular recording techniques were used to characterize monosynaptic inhibitory postsynaptic potentials (IPSPs) and currents (IPSCs) in rat hippocampal slices and to study the mechanism of paired‐pulse depression of these synaptic responses. This
C. Davies, S. Davies, G. Collingridge
semanticscholar   +1 more source

Roles of Kdm6a and Kdm6b in Regulation of Mammalian Neural Regeneration

Advanced Science, EarlyView.
This study reveals that Kdm6a plays key roles in repressing either peripheral nervous system (PNS) or central nervous system (CNS) axon regeneration, whereas Kdm6b is not involved in regulating CNS axon regeneration. Moreover, both demethylases are able to regulate CNS neuronal survival after injury, but with non‐overlapping mechanisms.
Shu‐Guang Yang, Chang‐Ping Li, Xue‐Wei Wang, Tao Huang, Cheng Qian, Qiao Li, Ling‐Rui Zhao, Si‐Yu Zhou, Chen‐Yun Ding, Rui Nie, Saijilafu, Yu‐Cai Hong, Chang‐Mei Liu, Feng‐Quan Zhou   +13 more
wiley   +1 more source

Approaches and Limitations in the Investigation of Synaptic Transmission and Plasticity

Frontiers in Synaptic Neuroscience, 2019
The numbers and strengths of synapses in the brain change throughout development, and even into adulthood, as synaptic inputs are added, eliminated, and refined in response to ongoing neural activity.
Stephen D. Glasgow, Ryan McPhedrain, Jeanne F. Madranges, Timothy E. Kennedy, Edward S. Ruthazer   +4 more
doaj   +1 more source