Results 91 to 100 of about 92,954 (316)

Dynamical principles in neuroscience [PDF]

, 2006
Dynamical modeling of neural systems and brain functions has a history of success over the last half century. This includes, for example, the explanation and prediction of some features of neural rhythmic behaviors.
Abarbanel, H. D. I., Abarbanel, H. D. I., Abeles, M., Abeles, M., Adrian, E. D., Allen I. Selverston, Amit, D., Amit, D. J., Andronov, A., Andronov, A., Andronov, A. A., Arbib, M. A., Arnold, V., Ashby, W. R., Baird, B., Bartos, M., Bartos, M., Bi, G., Bliss, T. V., Bondarenko, V., Borda, J. C., Canavier, C., Chay, T., Chklovskii, D. B., Cohen, M. A., Crevier, D., Cymbalyuk, G., de Nó, R. L., deCharms, R., Diwadkar, V. A., Duda, R., Elson, R. C., Fano, R. M., Fatt, P., Freeman, W., Freeman, W., Fuhrmann, G., Gallager, R. G., Gavrilov, N., Gerstner, W., Glass, L., Goroff, D., Grossberg, S., Guckenheimer, J., Hatsopoulos, N., Hebb, R., Henry D. I. Abarbanel, Hodgkin, A. L., Hopfield, J., Ichinohe, N., Ince, D., Izhikevich, E., Jones, S. R., Kandel, E. R., Kaplan, D., Katz, B., Kim, U., Kimpo, R. R., Koch, C., Konishi, M., Kuramoto, Y., Kuznetsov, Y., Landau, L. D., Lapicque, L., Lashley, K., Levi, R., Lindner, B., Lotka, A. J., Malkov, V., Maravall, M., Marder, E., Mikhail I. Rabinovich, Nicholls, J. G., Nowotny, T., Oscarsson, O., Ott, E., O’Reilly, R., Pablo Varona, Panchin, Y., Pikovsky, A., Poincaré, A., Poincaré, H., Prinz, A., Prinz, A. A., Rabinovich, M., Ramirez, J., Reinagel, P., Rosenblatt, F., Rowe, D., Saari, G., Segundo, J. P., Segundo, J. P., Senseman, D. M., Seung, H. S., Shadlen, M. N., Shepherd, G., Simmers A. J., Singer, W., Stein, S. G., Strogatz, S. H., Szekely, G., Szücs, A., Szücs, A., Szücs, A., Tsuda, I., Turrigiano, G. G., Varona, P., Volterra, V., Wang, X.-J., Wilson, H. R., Zhigulin, V. P.   +110 more
core   +2 more sources

Heterointerface‐Modulated Synthetic Synapses Exhibiting Complex Multiscale Plasticity

Advanced Science, EarlyView.
An asymmetric dual‐gate heterointerface‐regulated artificial synapse (HRAS) is developed, employing distinct ion concentrations and dielectric coupling to form precise dual‐interface channels. Through lateral modulation, HRAS realizes, for the first time, the intricate interplay of lateral inhibition/enhancement and multi‐level short‐ and long‐term ...
Xingji Liu, Yao Ni, Zujun Wang, Sunfu Wei, Xiao′en Chen, Jingjie Lin, Lu Liu, Boyang Yu, Yue Yu, Dengyun Lei, Yayi Chen, Jianfeng Zhang, Jing Qi, Wei Zhong, Yuan Liu   +14 more
wiley   +1 more source

Combination of High-density Microelectrode Array and Patch Clamp Recordings to Enable Studies of Multisynaptic Integration

Scientific Reports, 2017
We present a novel, all-electric approach to record and to precisely control the activity of tens of individual presynaptic neurons. The method allows for parallel mapping of the efficacy of multiple synapses and of the resulting dynamics of postsynaptic
David Jäckel, Douglas J. Bakkum, Thomas L. Russell, Jan Müller, Milos Radivojevic, Urs Frey, Felix Franke, Andreas Hierlemann   +7 more
doaj   +1 more source

Subcellular Imbalances in Synaptic Activity

Cell Reports, 2016
The dynamic interactions between synaptic excitation and inhibition (E/I) shape membrane potential fluctuations and determine patterns of neuronal outputs; however, the spatiotemporal organization of these interactions within a single cell is poorly ...
Naoya Takahashi, Chiaki Kobayashi, Tomoe Ishikawa, Yuji Ikegaya   +3 more
doaj   +1 more source

Nanoparticle‐Mediated CXCL12–CXCR4 Inhibition Reprograms Macrophages and Suppresses Gastric Carcinoma

Advanced Science, EarlyView.
Molecular mechanism study of self‐assembled M2pep‐Cs NPs/Plerixafor nanoparticles in targeting MΦ reprogramming by regulating the CXCL12–CXCR4 signaling pathway to enhance immune recognition and clearance of GC (Created by BioRender). Abstract Gastric carcinoma (GC) remains a major global health challenge, requiring novel therapeutic approaches.
Qianqian Cao, Xiaolei Cheng, Rongbin Lv, Dianshui Sun, Jihua Wang, Runjia Fu, Rumei Gong, Yueying Xiao, Qin Liu, Xiaomei Li   +9 more
wiley   +1 more source

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

Advanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich, Jing Wang, Ferdinand Althammer, Tim Schubert, Nina Kluck, Valery Grinevich, Stefanie Schmitteckert, Christian P. Schaaf, Gudrun A. Rappold   +8 more
wiley   +1 more source

State-dependent cell-type-specific membrane potential dynamics and unitary synaptic inputs in awake mice

eLife, 2018
The cellular and synaptic mechanisms driving cell-type-specific function during various cortical network activities and behaviors are poorly understood.
Aurélie Pala, Carl CH Petersen
doaj   +1 more source

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

Advanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo, Yuanyuan Li, Wensheng Li, Tongrui Wu, Yi Liu, Yacoubou Abdoul Razak Mahaman, Jianzhi Wang, Rong Liu, Wei Liu, Hui Shen, Xiaochuan Wang   +10 more
wiley   +1 more source

Complex events initiated by individual spikes in the human cerebral cortex.

PLoS Biology, 2008
Synaptic interactions between neurons of the human cerebral cortex were not directly studied to date. We recorded the first dataset, to our knowledge, on the synaptic effect of identified human pyramidal cells on various types of postsynaptic neurons and
Gábor Molnár, Szabolcs Oláh, Gergely Komlósi, Miklós Füle, János Szabadics, Csaba Varga, Csaba Varga, Pál Barzó, Gábor Tamás   +8 more
doaj   +1 more source

Implementing Multimodal Hardware Security with 2D α‐In2Se3 Ferroelectric Transistor

Advanced Science, EarlyView.
A multimodal secure transistor‐integrated in‐memory sensing and computing architecture is demonstrated by leveraging its electronic and optoelectronic synaptic behaviors. Key security primitives, such as anticounterfeiting, watermarking, logic locking, and camouflaging, are implemented within a compact single‐transistor structure, providing a scalable ...
Xinwei Zhang, Jiachao Zhou, Yishu Zhang, Jian Chai, Yongqing Bai, Hailiang Wang, Qian He, Xi Wang, Lin Wang, Yuda Zhao, Yang Xu, Bin Yu   +11 more
wiley   +1 more source