Results 221 to 230 of about 105,210 (313)

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Dexmedetomidine Reduces Presynaptic γ-Aminobutyric Acid Release and Prolongs Postsynaptic Responses in Layer 5 Pyramidal Neurons in the Primary Somatosensory Cortex of <i>Mice</i>. [PDF]

Int J Mol Sci
Tang B, Tang J, Huang Y.
europepmc   +1 more source

Elucidation of the zinc binding site in KCNQ channels

British Journal of Pharmacology, EarlyView.
Background and Purpose KCNQ1‐5 (Kv7.1–7.5) are members of a family of voltage‐gated potassium channels with prominent function in the nervous and cardiovascular systems and in epithelia. KCNQ channels are activated by intracellular free zinc, but the molecular mechanism of this effect is poorly understood and zinc binding sites within KCNQ channels are
Shuo Zhang, Xinhe Yang, Meng Yang, Yixue Cao, Sai Shi, Nikita Gamper, Haixia Gao   +6 more
wiley   +1 more source

PTEN in somatostatin neurons regulates fear and anxiety and is required for inhibitory synaptic connectivity within central amygdala. [PDF]

Front Cell Neurosci
Holford TW, Letourneau KN, Von-Walter C, Moncaleano D, Loomis CL, Bolton MM.   +5 more
europepmc   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Neurochemical crossroads: exploring the neurotransmitter network in chronic pain and depression comorbidity. [PDF]

Front Mol Neurosci
Ma M, Zhang Y, Tao K, Lu Z.
europepmc   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

The Oviposition Inhibitory Neuron is a Potential Hub of Multi-Circuit Integration in the <i>Drosophila</i> Brain. [PDF]

eNeuro
Weber-Langstaff RA, Srivastava P, Kunin AB, Gutierrez GJ.   +3 more
europepmc   +1 more source

Simultaneous encoding of sensory features: the role of multiplexing and noise in tactile perception and neural representation

Biological Reviews, EarlyView.
ABSTRACT The nervous system's capacity to process complex stimuli has long intrigued neuroscientists, with multiplexing now recognized as a fundamental neural coding strategy. Multiplexing refers to the simultaneous encoding of multiple stimulus features via vi distinct components of neuronal responses, such as firing rates and precise temporal spike ...
Mohammad Amin Kamaleddin
wiley   +1 more source