Results 51 to 60 of about 258,461 (334)

The positive allosteric modulator of NMDA receptors, GNE‐9278, blocks the ethanol‐induced decrease of excitability in developing retrosplenial cortex neurons from mice

Neuropsychopharmacology Reports, 2023
Binge‐like exposure to ethanol during the brain growth spurt triggers apoptotic neurodegeneration in multiple brain regions, including the retrosplenial cortex, a brain region that is part of the hippocampal‐diencephalic‐cingulate memory network. This is
Clark W. Bird, Carlos F. Valenzuela
doaj   +1 more source

Co-exposure of melamine and cyanuric acid as a risk factor for oxidative stress and energy metabolism: Adverse effects on hippocampal neuronal and synaptic function induced by excessive ROS production

Ecotoxicology and Environmental Safety, 2022
Melamine (MEL) and cyanuric acid (CA) alone have relatively low toxicity, but together they may cause serious damage to multiple organs, including the central nervous system, however, the underlying mechanism is unknown. This study aimed to determine and
Wei Sun, Xiao Chen, Yazi Mei, Xiaoliang Li, Yang Yang, Lei An   +5 more
doaj   +1 more source

Accumulation of Dense Core Vesicles in Hippocampal Synapses Following Chronic Inactivity. [PDF]

, 2018
The morphology and function of neuronal synapses are regulated by neural activity, as manifested in activity-dependent synapse maturation and various forms of synaptic plasticity.
Bi, Guo-Qiang, Lau, Pak-Ming, Liu, Yun-Tao, Tao, Chang-Lu, Zhou, Z Hong   +4 more
core   +2 more sources

Inhibitory or excitatory? Optogenetic interrogation of the functional roles of GABAergic interneurons in epileptogenesis

Journal of Biomedical Science, 2017
Alteration in the excitatory/inhibitory neuronal balance is believed to be the underlying mechanism of epileptogenesis. Based on this theory, GABAergic interneurons are regarded as the primary inhibitory neurons, whose failure of action permits ...
Hui Ye, Stephanie Kaszuba
doaj   +1 more source

Modulation of the GABAergic pathway for the treatment of fragile X syndrome. [PDF]

, 2014
Fragile X syndrome (FXS) is the most common genetic cause of intellectual disability and the most common single-gene cause of autism. It is caused by mutations on the fragile X mental retardation gene (FMR1) and lack of fragile X mental retardation ...
Hagerman, Randi J, Hare, Emma B, Lozano, Reymundo   +2 more
core   +1 more source

The energy demand of fast neuronal network oscillations: insights from brain slice preparations

Frontiers in Pharmacology, 2012
Fast neuronal network oscillations in the gamma range (30-100 Hz) in the cerebral cortex have been implicated in higher cognitive functions such as sensual perception, working memory, and, perhaps, consciousness. However, little is known about the energy
Oliver eKann
doaj   +1 more source

Alterations in brain connectivity due to plasticity and synaptic delay

, 2017
Brain plasticity refers to brain's ability to change neuronal connections, as a result of environmental stimuli, new experiences, or damage. In this work, we study the effects of the synaptic delay on both the coupling strengths and synchronisation in a ...
Batista, A. M., Borges, F. S., Borges, R. R., Caldas, I. L., Iarosz, K. C., Lameu, E. L., Macau, E. E. N., Protachevicz, P. R., Viana, R. L.   +8 more
core   +1 more source

Dynamical principles in neuroscience [PDF]

, 2006
Dynamical modeling of neural systems and brain functions has a history of success over the last half century. This includes, for example, the explanation and prediction of some features of neural rhythmic behaviors.
Abarbanel, H. D. I., Abarbanel, H. D. I., Abeles, M., Abeles, M., Adrian, E. D., Allen I. Selverston, Amit, D., Amit, D. J., Andronov, A., Andronov, A., Andronov, A. A., Arbib, M. A., Arnold, V., Ashby, W. R., Baird, B., Bartos, M., Bartos, M., Bi, G., Bliss, T. V., Bondarenko, V., Borda, J. C., Canavier, C., Chay, T., Chklovskii, D. B., Cohen, M. A., Crevier, D., Cymbalyuk, G., de Nó, R. L., deCharms, R., Diwadkar, V. A., Duda, R., Elson, R. C., Fano, R. M., Fatt, P., Freeman, W., Freeman, W., Fuhrmann, G., Gallager, R. G., Gavrilov, N., Gerstner, W., Glass, L., Goroff, D., Grossberg, S., Guckenheimer, J., Hatsopoulos, N., Hebb, R., Henry D. I. Abarbanel, Hodgkin, A. L., Hopfield, J., Ichinohe, N., Ince, D., Izhikevich, E., Jones, S. R., Kandel, E. R., Kaplan, D., Katz, B., Kim, U., Kimpo, R. R., Koch, C., Konishi, M., Kuramoto, Y., Kuznetsov, Y., Landau, L. D., Lapicque, L., Lashley, K., Levi, R., Lindner, B., Lotka, A. J., Malkov, V., Maravall, M., Marder, E., Mikhail I. Rabinovich, Nicholls, J. G., Nowotny, T., Oscarsson, O., Ott, E., O’Reilly, R., Pablo Varona, Panchin, Y., Pikovsky, A., Poincaré, A., Poincaré, H., Prinz, A., Prinz, A. A., Rabinovich, M., Ramirez, J., Reinagel, P., Rosenblatt, F., Rowe, D., Saari, G., Segundo, J. P., Segundo, J. P., Senseman, D. M., Seung, H. S., Shadlen, M. N., Shepherd, G., Simmers A. J., Singer, W., Stein, S. G., Strogatz, S. H., Szekely, G., Szücs, A., Szücs, A., Szücs, A., Tsuda, I., Turrigiano, G. G., Varona, P., Volterra, V., Wang, X.-J., Wilson, H. R., Zhigulin, V. P.   +110 more
core   +2 more sources

Medial Ganglionic Eminence Progenitors Transplanted into Hippocampus Integrate in a Functional and Subtype-Appropriate Manner. [PDF]

, 2017
Medial ganglionic eminence (MGE) transplantation rescues disease phenotypes in various preclinical models with interneuron deficiency or dysfunction, including epilepsy.
Baraban, Scott C, Hsieh, Jui-Yi
core   +1 more source

Myelination of parvalbumin interneurons shapes the function of cortical sensory inhibitory circuits

Nature Communications, 2020
Myelination of projection neurons by oligodendrocytes is key to optimize action potential conduction over long distances. However, a large fraction of myelin enwraps the axons of parvalbumin-positive fast-spiking interneurons (FSI), exclusively involved ...
N. Benamer, Marie Vidal, Maddalena Balia, M. C. Angulo   +3 more
semanticscholar   +1 more source