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Journal of Allergy and Clinical Immunology, 2004
Mast cells have been most extensively studied in their traditional role as an early effector cell of allergic disease. However, in the majority of individuals, it might be the role of this cell as a sentinel in host defense that is most important.
Jean S, Marshall, Dunia M, Jawdat
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Mast cells have been most extensively studied in their traditional role as an early effector cell of allergic disease. However, in the majority of individuals, it might be the role of this cell as a sentinel in host defense that is most important.
Jean S, Marshall, Dunia M, Jawdat
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Immunological Reviews, 2000
Summary: Mast cells are known to be the main effector cells in the elicitation of the IgE‐mediated allergic response. The specific location of mast cells within tissues that interface the external environment, and the extent of their functional capacity, including the ability to phagocytose and to produce and secrete a wide spectrum of mediators, have ...
Y A, Mekori, D D, Metcalfe
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Summary: Mast cells are known to be the main effector cells in the elicitation of the IgE‐mediated allergic response. The specific location of mast cells within tissues that interface the external environment, and the extent of their functional capacity, including the ability to phagocytose and to produce and secrete a wide spectrum of mediators, have ...
Y A, Mekori, D D, Metcalfe
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Current Opinion in Immunology, 2005
NK cells have an important role in innate immune responses, particularly in anti-viral immunity. Recent studies have revealed a molecular basis for NK cell recognition of virus-infected cells, implicating the activating KIR and Ly49 receptors and NKG2D in this process.
Jessica A, Hamerman +2 more
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NK cells have an important role in innate immune responses, particularly in anti-viral immunity. Recent studies have revealed a molecular basis for NK cell recognition of virus-infected cells, implicating the activating KIR and Ly49 receptors and NKG2D in this process.
Jessica A, Hamerman +2 more
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Trends in Immunology, 2013
Asthma is an inflammatory disease of the airways associated with a T helper (Th)2 response. Such a response in the lungs requires complex interactions between innate cells and structural cells. Dendritic cells (DCs) are pivotal during sensitization to allergens but clearly require epithelium-derived signals to become activated.
Julie, Deckers +2 more
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Asthma is an inflammatory disease of the airways associated with a T helper (Th)2 response. Such a response in the lungs requires complex interactions between innate cells and structural cells. Dendritic cells (DCs) are pivotal during sensitization to allergens but clearly require epithelium-derived signals to become activated.
Julie, Deckers +2 more
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Innate immune cells in reproduction
Journal of Obstetrics and Gynaecology Research, 2018AbstractFetomaternal immune tolerance is required to prevent fetal rejection during pregnancy; simultaneously, the maternal immune system must also protect the fetus from harmful endogenous and exogenous antigens, including those associated with viral and bacterial infections.
Yasuyuki Negishi +3 more
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Trends in Immunology, 2011
When faced with an invasion of microbes or non-infectious tissue damage, surrounding cells send for help. Leukocytes respond to these signals and infiltrate the injured tissue to help fight infection and cleanup damage. The idea that innate immune cells are mobilized early in the inflammatory response is not new.
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When faced with an invasion of microbes or non-infectious tissue damage, surrounding cells send for help. Leukocytes respond to these signals and infiltrate the injured tissue to help fight infection and cleanup damage. The idea that innate immune cells are mobilized early in the inflammatory response is not new.
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Science, 2020
Immunology Immunological memory is a phenomenon by which immune cells can quickly recognize an antigen that the host has previously encountered. Certain cells of the innate immune system exhibit memory-like responses know as trained immunity. Rapid, antigen-specific secondary (anamnestic) responses were long thought to be the domain of B and T cells ...
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Immunology Immunological memory is a phenomenon by which immune cells can quickly recognize an antigen that the host has previously encountered. Certain cells of the innate immune system exhibit memory-like responses know as trained immunity. Rapid, antigen-specific secondary (anamnestic) responses were long thought to be the domain of B and T cells ...
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Innate Immune System Cells in Atherosclerosis
Archives of Medical Research, 2014Atherosclerosis is a chronic inflammatory disease of the arterial wall characterized by innate and adaptive immune system involvement. A key component of atherosclerotic plaque inflammation is the persistence of different innate immune cell types including mast cells, neutrophils, natural killer cells, monocytes, macrophages and dendritic cells ...
Luis, Chávez-Sánchez +5 more
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Gammadelta T Cells: Innately Adaptive Immune Cells?
International Reviews of Immunology, 2013T cells employ a cell surface heterodimeric molecule, the T cell receptor (TCR), to recognize specific antigens (Ags) presented by major histocompatibility complex (MHC) molecules and carry out adaptive immune responses. Most T cells possess a TCR with an α and a β chain.
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2018
This chapter describes the broad variety of mobile cells of the innate immune system. The cells include phagocytic cells such as monocytes/macrophages, polymorphonuclear neutrophils, and dendritic cells; cells that release inflammatory mediators such as eosinophils, basophils, and mast cells; and innate lymphoid cells such as natural killer cells as ...
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This chapter describes the broad variety of mobile cells of the innate immune system. The cells include phagocytic cells such as monocytes/macrophages, polymorphonuclear neutrophils, and dendritic cells; cells that release inflammatory mediators such as eosinophils, basophils, and mast cells; and innate lymphoid cells such as natural killer cells as ...
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