The evolution of resistance through costly acquired immunity [PDF]
, 2004 We examine the evolutionary dynamics of resistance to parasites through acquired immunity. Resistance can be achieved through the innate mechanisms of avoidance of infection and reduced pathogenicity once infected, through recovery from infection and ...
Boots M., Michael Boots, Roger G. Bowers
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The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans
Nature Communications, 2020 lncRNAs are transcriptional regulators, but little is known of them functioning as negative feedback regulators of inflammation in humans. Here, the authors show that the human lncRNA LUCAT1 sequesters STAT1 to limit JAK/STAT signaling and the ...
Shiuli Agarwal +7 more
doaj +1 more source
In vivo detection of lamellocytes in Drosophila melanogaster. [PDF]
, 2009 Drosophila has recently become a powerful model organism for studies of innate immunity. The cellular elements of innate immunity in Drosophila, the hemocytes, have been characterized by morphological criteria, molecular markers, and cell-type-specific ...
Brand +17 more
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TLR4 links innate immunity and fatty acid-induced insulin resistance.
Journal of Clinical Investigation, 2006 TLR4 is the receptor for LPS and plays a critical role in innate immunity. Stimulation of TLR4 activates proinflammatory pathways and induces cytokine expression in a variety of cell types.
Hang Shi +5 more
semanticscholar +1 more source
New insights into the evasion of host innate immunity by Mycobacterium tuberculosis
Cellular & Molecular Immunology, 2020 Mycobacterium tuberculosis (Mtb) is an extremely successful intracellular pathogen that causes tuberculosis (TB), which remains the leading infectious cause of human death.
Qiyao Chai, Lin Wang, C. Liu, Baoxue Ge
semanticscholar +1 more source
Hypercytokinemia: Increased or decreased innate immunity? [PDF]
, 2008 The adipose tissue is an active endocrine organ which secretes proinflammatory cytokines and chemokines resulting into raised serum levels. Hypercytokinemia has been interpreted as raised level of innate immunity and its evolution is interpreted as a ...
Milind Watve +2 more
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Targeting RIP Kinases in Chronic Inflammatory Disease
Biomolecules, 2021 Chronic inflammatory disorders are characterised by aberrant and exaggerated inflammatory immune cell responses. Modes of extrinsic cell death, apoptosis and necroptosis, have now been shown to be potent drivers of deleterious inflammation, and mutations
Mary Speir +4 more
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Toll-like receptors in innate immunity.
International Immunology, 2004 Functional characterization of Toll-like receptors (TLRs) has established that innate immunity is a skillful system that detects invasion of microbial pathogens.
K. Takeda, S. Akira
semanticscholar +1 more source
Early Interferon-γ Production in Human Lymphocyte Subsets in Response to Nontyphoidal Salmonella Demonstrates Inherent Capacity in Innate Cells [PDF]
, 2010 Background Nontyphoidal Salmonellae frequently cause life-threatening bacteremia in sub-Saharan Africa. Young children and HIV-infected adults are particularly susceptible.
Anna E. Seeley +5 more
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Innate immune memory: implications for development of pediatric immunomodulatory agents and adjuvanted vaccines [PDF]
, 2014 Unique features of immunity early in life include a distinct immune system particularly reliant on innate immunity, with weak T helper (Th)1-polarizing immune responses, and impaired responses to certain vaccines leading to a heightened susceptibility to
Levy, Ofer, Netea, Mihai G.
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