Results 51 to 60 of about 2,416,042 (300)

Prevention of Diabetes-Associated Cognitive Dysfunction Through Oral Administration of Lipopolysaccharide Derived From Pantoea agglomerans

Frontiers in Immunology, 2021
Diabetes-related cognitive dysfunction (DRCD) is a serious complication induced by diabetes. However, there are currently no specific remedies for DRCD. Here, we show that streptozotocin-induced DRCD can be prevented without causing side effects through ...
Haruka Mizobuchi, Kazushi Yamamoto, Masashi Yamashita, Yoko Nakata, Hiroyuki Inagawa, Hiroyuki Inagawa, Hiroyuki Inagawa, Chie Kohchi, Chie Kohchi, Gen-Ichiro Soma, Gen-Ichiro Soma, Gen-Ichiro Soma   +11 more
doaj   +1 more source

Influence of tumors on protective anti-tumor immunity and the effects of irradiation [PDF]

, 2013
Innate and adaptive immunity play important roles in the development and progression of cancer and it is becoming apparent that tumours can influence the induction of potentially protective responses in a number of ways.
Alan Graham Pockley, Gabriele eMulthoff, Gabriele eMulthoff, Gemma Ann Foulds, Gemma Ann Foulds, Jürgen eRadons, Mira eKreuzer   +6 more
core   +2 more sources

Innate immune defects in HIV permissive cell lines. [PDF]

, 2016
Primary CD4+ T cells and cell lines differ in their permissiveness to HIV infection. Impaired innate immunity may contribute to this different phenotype. We used transcriptome profiling of 1503 innate immunity genes in primary CD4+ T cells and permissive
Ciuffi, A., Martinez, R., Muñoz, M., Rausell, A., Roger, T., Telenti, A.   +5 more
core   +4 more sources

Baseline data collections of lipopolysaccharide content in 414 herbal extracts and its role in innate immune activation

Scientific Reports
Some herbal extracts contain relatively high amounts of lipopolysaccharide (LPS). Because orally administered LPS activates innate immunity without inducing inflammation, it plays a role as an active ingredient in herbal extracts.
Vindy Tjendana Tjhin, Masataka Oda, Masashi Yamashita, Tomoko Iwaki, Yasuko Fujita, Koji Wakame, Hiroyuki Inagawa, Gen-Ichiro Soma   +7 more
doaj   +1 more source

Vascular Endothelial Cells and Innate Immunity.

Arteriosclerosis, Thrombosis and Vascular Biology, 2020
In addition to the roles of endothelial cells (ECs) in physiological processes, ECs actively participate in both innate and adaptive immune responses. We previously reported that, in comparison to macrophages, a prototypic innate immune cell type, ECs ...
Ying Shao, J. Saredy, William Y. Yang, Yu Sun, Yifan Lu, Fatma Saaoud, C. Drummer, Candice Johnson, Keman Xu, Xiaohua Jiang, Hong Wang, Xiaofeng Yang   +11 more
semanticscholar   +1 more source

Livestock abundance predicts vampire bat demography, immune profiles, and bacterial infection risk [PDF]

, 2018
Human activities create novel food resources that can alter wildlife–pathogen interactions. If resources amplify or dampen, pathogen transmission probably depends on both host ecology and pathogen biology, but studies that measure responses to ...
Altizer, Sonia, Becker, Daniel, Bentz, Alexandra B., Camus, Melinda S., Carrera, Jorge E., Chizhikov, Vladimir E., Czirjak, Gabor A., Fenton, M. Brock, Gilbert, Amy T., Navara, Kristen J., Recuenco, Sergio E., Simmons, Nancy B., Streicker, Daniel, Volokhov, Dmitriy V.   +13 more
core   +3 more sources

Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application

Nature Communications
Inflammasome activation results in the cleavage of gasdermin D (GSDMD) by pro-inflammatory caspases. The N-terminal domains (GSDMDNT) oligomerize and assemble pores penetrating the target membrane.
Lisa D. J. Schiffelers, Yonas M. Tesfamariam, Lea-Marie Jenster, Stefan Diehl, Sophie C. Binder, Sabine Normann, Jonathan Mayr, Steffen Pritzl, Elena Hagelauer, Anja Kopp, Assaf Alon, Matthias Geyer, Hidde L. Ploegh, Florian I. Schmidt   +13 more
doaj   +1 more source

Effectors Targeting the Unfolded Protein Response during Intracellular Bacterial Infection

Microorganisms, 2021
The unfolded protein response (UPR) is a homeostatic response to endoplasmic reticulum (ER) stress within eukaryotic cells. The UPR initiates transcriptional and post-transcriptional programs to resolve ER stress; or, if ER stress is severe or prolonged,
Manal H. Alshareef, Elizabeth L. Hartland, Kathleen McCaffrey   +2 more
doaj   +1 more source

Rusty microglia: trainers of innate immunity in Alzheimer's disease [PDF]

, 2018
Alzheimer's disease, the most common form of dementia, is marked by progressive cognitive and functional impairment believed to reflect synaptic and neuronal loss.
Adonis Sfera, Adonis Sfera, Amy I. Price, Carolina Osorio, Eddie Diaz, Michael Cummings, Roberto Gradini   +6 more
core   +2 more sources

Gasdermin E deficiency limits inflammation and lung damage during influenza virus infection

Cell Death and Disease
Severe influenza A virus (IAV) infections are associated with hyperinflammation and significant lung damage. Gasdermin E (GSDME) mediates pyroptosis, a lytic and inflammatory type of cell death.
Sarah Rosli, Rebecca L. Ambrose, Christopher M. Harpur, Maggie Lam, Christopher Hodges, Kristian T. Barry, Alison C. West, Ashley Mansell, Kate E. Lawlor, Michelle D. Tate   +9 more
doaj   +1 more source